A5045702596- Nanoplatforms for cancer theranostics
- Radiopharmaceutical Chemistry and Applications
- Ultrasound in Clinical Applications
- Nanoparticle-Based Drug Delivery
- Cancer, Hypoxia, and Metabolism
- Respiratory Support and Mechanisms
- Cancer-related Molecular Pathways
- Photodynamic Therapy Research Studies
- Sleep and related disorders
- Hemodynamic Monitoring and Therapy
- Venous Thromboembolism Diagnosis and Management
- Advanced Nanomaterials in Catalysis
- Graphene and Nanomaterials Applications
- Intensive Care Unit Cognitive Disorders
- Medical Imaging Techniques and Applications
- Photoacoustic and Ultrasonic Imaging
- Radiomics and Machine Learning in Medical Imaging
- Advanced biosensing and bioanalysis techniques
- Sleep and Wakefulness Research
- Graphene research and applications
- Metal-Organic Frameworks: Synthesis and Applications
- Ubiquitin and proteasome pathways
- Sepsis Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Nanocluster Synthesis and Applications
First Hospital of China Medical University
2016-2025
China Medical University
2016-2025
Soochow University
2015-2025
Jilin University
2025
Beijing Chang'an Integrated Traditional Chinese and Western Medicine Hospital
2025
Yuhuangding Hospital
2024
Qingdao University
2024
Peking University Sixth Hospital
2019-2023
Peking University
2019-2023
Southwest University
2023
Hypoxia not only promotes tumor metastasis but also strengthens resistance to therapies that demand the involvement of oxygen, such as radiation therapy and photodynamic (PDT). Herein, taking advantage high reactivity manganese dioxide (MnO 2 ) nanoparticles toward endogenous hydrogen peroxide (H O within microenvironment generate , multifunctional chlorine e6 (Ce6) loaded MnO with surface polyethylene glycol (PEG) modification (Ce6@MnO ‐PEG) are formulated achieve enhanced tumor‐specific...
Near-infrared upconversion luminescent nanoprobes with outstanding tissue penetration depth and excellent tumor targeting ability realized the detection of lymph node metastasis.
Tamoxifen (TAM) is the earliest non-steroidal antiestrogen drug, which has been widely used in endocrine therapy targeting breast cancer. The aim of present study was to investigate effect TAM on proliferation, apoptosis, migration and invasion estrogen‑positive (ER+) cancer cell line MCF‑7 vitro, elucidate its mechanisms. It demonstrated that suppressed invasion, induced apoptosis cells. Further investigation revealed mitochondrial membrane potential amount ATP were significantly decreased...
Plant-derived chlorophyll derivatives with a porphyrin ring structure and intrinsic photosynthesis have been widely used in biomedicine for cancer theranostics. Owing to their poor water solubility, are very difficult use biomedical applications. In this work, pyropheophorbide acid (PPa) (liposome/PPa) nanoparticles, liposome-encapsulated derivative, designed tri-model imaging guided photodynamic therapy (PDT) of cancer. The obtained liposome/PPa nanoparticles significantly enhance the...
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a devastatingly malignant tumor with high mortality. However, current strategies to treat PDAC generally have low efficacy and side-effects, therefore, effective treatment against remains an urgent need. Results We report semiconducting polymer nano-radiopharmaceutical intrinsic photothermal capability labeling therapeutic radioisotope 177 Lu ( Lu-SPN-GIP) for combined radio- therapy of pancreatic tumor. Lu-SPN-GIP endowed good...
Transarterial radioembolization (TARE) is a highly effective localized radionuclide therapy that has been successfully used to treat hepatocellular carcinoma (HCC). Extensive research conducted on the use of radioactive microspheres (MSs) in TARE, and development ideal MSs crucial for clinical trials patient treatment. This study presents MS TARE HCC. These MSs, referred as
Turning to critical illness is a common stage of various diseases and injuries before death. Patients usually have complex health conditions, while the treatment process involves wide range content, along with high requirements for doctor's professionalism multi-specialty teamwork, as well great demand time-sensitive treatments. However, this not matched care professionals current state medical in China. Telemedicine, which shortens distance gap disease diagnosis treatments regions through...
<sec><title>Objective</title> To investigate the medium- and long-term efficacy of Percutaneous mechanical thrombectomy (PMT) combined with stent implantation for treatment iliac vein stenosis lower limb deep thrombosis. </sec><sec><title>Methods</title> Clinical follow-up data 125 patients thrombosis who underwent PMT at five hospitals in northern Zhejiang province from January 2017 to June 2021 were collected. The thrombus clearance rate, recurrence post-thrombotic syndrome (PTS)...
Abstract Transarterial radioembolization (TARE) is an established clinical therapy for treating patients with intermediate to advanced hepatocellular carcinoma (HCC) or those who cannot undergo radical treatment. However, the delivery of a high radiation dose associated several adverse effects, such as pneumonitis. Additionally, available radioactive microspheres (MSs) are dense and unsuitable interventional delivery. This study proposes use commercial CalliSpheres polyvinyl alcohol (PVA)...
In co-host sensitized fluorescent devices, the triplet energy loss caused by conventional dopant (CFD) in emitting layer (EML) prevents further improvement device efficiency performance. this article,...
Radiation therapy is one of the core means tumor treatment, especially in local control and radical treatment has an irreplaceable role. However, radiotherapy resistance major...
Geological disasters like debris flows often profoundly affect land use, causing changes in the surrounding environment and influencing decisions of local farmers. This study selected 122 flow gullies Anning River Basin as research units developed a novel analytical approach to quantify use responses flows. Key indicators derived from this methodology were combined with ordinary least squares (OLS) regression analysis identify critical factors governing spatial distribution patterns use....
Immune checkpoint blockade (ICB) therapy is promising to revolutionize cancer regimens, but the low response rate and lack of a suitable patient stratification method have impeded universal profit patients. Noninvasive positron emission tomography (PET) imaging in whole body, upon coupling with specific biomarkers closely related immune response, could provide spatiotemporal information prescribe therapy. Herein, we demonstrate that antisilencing function 1a (ASF1a) serve as biomarker target...
Abstract Pulmonary embolism (PE) is a clinical emergency that will increase the mortality if complicated with unstable hemodynamics. Because of its nonspecific symptoms, it’s great challenge to make PE diagnosis. The golden standard diagnose computed tomography pulmonary artery (CTPA), but diagnosis also composed evaluation risk factors, possibilities, and stratification. Ultrasonography may detect right ventricle strain related hemodynamic change, intravascular thrombosis, thrombosis in...
Subclinical anxiety, depressive and somatic symptoms appear closely related. However, it remains unclear whether mediate the association between subclinical anxiety what underlying neuroimaging mechanisms are for mediating effect.Data of healthy participants (n = 466) in remission major disorder 53) were obtained from Human Connectome Project. The Achenbach Adult Self-Report was adopted to assess symptoms. All completed four runs resting-state functional magnetic resonance imaging. Mediation...