A5006402659- Mitochondrial Function and Pathology
- Genetic and Kidney Cyst Diseases
- Renal and related cancers
- Pluripotent Stem Cells Research
- Chronic Lymphocytic Leukemia Research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Sphingolipid Metabolism and Signaling
- Head and Neck Cancer Studies
- Metabolism and Genetic Disorders
- Autoimmune and Inflammatory Disorders Research
- Immune cells in cancer
- Chronic Myeloid Leukemia Treatments
- Galectins and Cancer Biology
- Protein Tyrosine Phosphatases
- Animal testing and alternatives
- Cancer, Hypoxia, and Metabolism
- Tissue Engineering and Regenerative Medicine
- Microtubule and mitosis dynamics
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Hedgehog Signaling Pathway Studies
- Lymphoma Diagnosis and Treatment
- ATP Synthase and ATPases Research
Sanofi (United States)
2024
University of Massachusetts Amherst
2015-2023
Bakulev Scientific Center for Cardiovascular Surgery Russian Academy of Medical Sciences
2016
Alice Ho Miu Ling Nethersole Hospital
2016
Abstract The success of the CD8 T cell-mediated immune response against infections and tumors depends on formation a long-lived memory pool, protection effector cells from exhaustion. advent checkpoint blockade therapy has significantly improved anti-tumor therapeutic outcomes by reversing cell exhaustion, but fails to generate with potential. Here, using in vivo mouse models, we show that let-7 miRNAs determine fate, where maintenance expression during early activation results tumor...
Neuroinflammation in the central nervous system (CNS), driven largely by resident phagocytes, has been proposed as a significant contributor to disability accumulation multiple sclerosis (MS) but not addressed therapeutically. Bruton's tyrosine kinase (BTK) is expressed both B-lymphocytes and innate immune cells, including microglia, where its role poorly understood. BTK inhibition may provide therapeutic benefit within CNS targeting adaptive immunity-mediated disease progression MS. Using...
Mitochondria are essential for energy production and although they have their own genome, many nuclear-encoded mitochondrial ribosomal proteins (MRPs) required proper function of the organelle. Although mutations in MRPs been associated with human diseases, little is known about role during development. Presented here null phenotypes 21 in-depth characterization mouse embryos mutant Mrp genes Mrpl3, Mrpl22, Mrpl44, Mrps18c Mrps22 Loss each MRP results successful implantation egg-cylinder...
Microspherule protein 1 (MCRS1, also known as MSP58) is an evolutionarily conserved that has been implicated in various biological processes. Although a variety of functions have attributed to MCRS1 vitro , mammalian not studied vivo . Here we report essential during early murine development. Mcrs1 mutant embryos exhibit normal morphology at the blastocyst stage but cannot be recovered gastrulation, suggesting implantation failure. Outgrowth (OG) assays reveal blastocysts do form typical...
There are currently no screening tests in routine use for oral and pharyngeal cancer beyond visual inspection palpation, which provided on an opportunistic basis, indicating a need development of novel methods early detection, particularly high-risk populations. We sought to address this through comprehensive interrogation CpG island methylation rinse samples. used the Infinium HumanMethylation450 BeadArray interrogate DNA samples collected from 154 patients with incident or carcinoma prior...
The dynein axonemal assembly factor (Dnaaf) protein family is involved in preassembly and stability of arms before they are transported into the cilia. In humans, mutations DNAAF genes lead to several diseases related cilia defects such as primary ciliary dyskinesia (PCD; OMIM: 612518). Patients with PCD experience malfunctions motility, which can result inflammation infection respiratory tract among other defects. Previous studies have identified that a mutation DNAAF2 results 40% these...
<h3>Objective:</h3> To characterize a central nervous system (CNS)-penetrant, tolebrutinib-like Bruton's tyrosine kinase inhibitor (BTKi) in murine experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS) for its potential to modulate disease progression and expression genes linked disease-associated microglia (DAM). <h3>Background:</h3> BTK inhibition may slow people with MS by targeting microglia-driven neuroinflammation the CNS. We previously showed that structural...
While significant advances have been made in understanding renal pathophysiology, less is known about the role of glycosphingolipid (GSL) metabolism driving organ dysfunction. Here, we used a small molecule inhibitor glucosylceramide synthase to modulate GSL levels three mouse models distinct pathologies: Alport syndrome (Col4a3 KO), polycystic kidney disease (Nek8jck), and steroid-resistant nephrotic (Nphs2 cKO). At tissue level, identified core immune-enriched transcriptional signature...
be after title page and numbered 1. -It should not exceed 250 words for major articles; case reports have abstracts of no more than 100 words.-At the end abstract, provide a maximum 6 key suitable indexing.-Abbreviations kept to minimum must explained when they first appear; use, abbreviations alone may used.
ABSTRACT Nuclear-encoded mitochondrial ribosomal proteins (MRPs) are crucial for function and hence cellular energy production. A new paper in Development investigates the of MRPs early mouse development, thanks to a battery knockout mutants. We caught up with first author (and recent graduate) Agnes Cheong her supervisor Jesse Mager, Associate Professor at Department Veterinary Animal Sciences University Massachusetts, Amherst, find out more. This article has an associated ‘The people...