A5028420877- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Autoimmune and Inflammatory Disorders
- Inflammatory Bowel Disease
- Schizophrenia research and treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Diet and metabolism studies
- Colorectal Cancer Surgical Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Mental Health and Psychiatry
- Microscopic Colitis
- Pelvic and Acetabular Injuries
- Clinical Reasoning and Diagnostic Skills
- Anesthesia and Pain Management
- Biomedical Ethics and Regulation
- Pregnancy-related medical research
- Hip disorders and treatments
- Mental Health and Patient Involvement
- Bipolar Disorder and Treatment
- Health Policy Implementation Science
- Pelvic floor disorders treatments
- Anorectal Disease Treatments and Outcomes
- Musculoskeletal pain and rehabilitation
- Autoimmune and Inflammatory Disorders Research
- Obesity and Health Practices
University of Sheffield
2016-2025
Background Optimal surgical intervention for low-grade haemorrhoids is unknown. Rubber band ligation (RBL) probably the most common intervention. Haemorrhoidal artery (HAL) a novel alternative that may be more efficacious. Objective The comparison of HAL with RBL treatment grade II/III haemorrhoids. Design A multicentre, parallel-group randomised controlled trial. Perspective UK NHS and Personal Social Services. Setting 17 Trusts. Participants Patients aged ≥ 18 years presenting (second-...
BackgroundA previous controlled trial of autologous haematopoietic stem-cell transplantation (HSCT) in patients with refractory Crohn's disease did not meet its primary endpoint and reported high toxicity. We aimed to assess the safety efficacy HSCT an immune-ablative regimen reduced intensity versus standard care this patient population.MethodsThis open-label, multicentre, randomised was conducted nine National Health Service hospital trusts across UK. Adults (aged 18–60 years) active on...
Background Obesity is twice as common in people with schizophrenia the general population. The National Institute for Health and Care Excellence guidance recommends that psychosis or schizophrenia, especially those taking antipsychotics, be offered a healthy eating physical activity programme by their mental health care provider. There insufficient evidence to inform how these lifestyle services should commissioned. Objectives To develop intervention first episode evaluate its clinical...
Intestinal inflammation in Crohn's disease (CD) is caused by mucosal immune system reactivity to luminal antigen and results debilitating symptoms, reduced quality of life, impaired work productivity significant health care costs. Not all patients respond conventional biologic therapies, with chronic ensuing. Although surgical resection may be required, frequently returns surgery not an option, or declined. Case reports suggest potential benefit after haematopoietic stem cell transplant...
Aims The Bracing Adolescent Idiopathic Scoliosis (BASIS) study is a randomized controlled non-inferiority pragmatic trial of ‘full-time bracing’ (FTB) compared to ‘night-time (NTB) for the treatment adolescent idiopathic scoliosis (AIS). We anticipated that recruiting patients BASIS would be challenging, as it paediatric comparing two markedly different bracing pathways. No previous studies have experiences AIS treated with FTB those NTB. This qualitative was embedded in explore families’...
Abstract Background Good Clinical Practice guidelines issued in 2016 encourage risk-based approaches to monitoring clinical trials. This study compared current risk assessment and UK Trials Units (CTUs) with the published guidance makes recommendations for pragmatic Methods An online survey of Research Collaboration registered CTUs was administered via email invitation. Forty-nine units were invited, 23 responded. Respondents also invited share copies templates. Results Most reported using...
People with schizophrenia are two to three times more likely be overweight than the general population. The UK National Institute of Health and Care Excellence (NICE) recommends an annual physical health review signposting to, or provision of, a lifestyle programme address weight concerns obesity. purpose this randomised controlled trial is assess whether group-based structured education can help people lose weight. Design: programme. 10 community mental trusts. 396 adults schizophrenia,...
The number of people with diabetes is growing rapidly. Diabetes can cause nerve damage leading to severe pain in the feet, legs and hands, which known as diabetic peripheral neuropathic (DPNP). In UK, National Institute for Health Care Excellence (NICE) recommends amitriptyline, duloxetine, pregabalin or gabapentin initial treatment DPNP. If this not effective, adding one other drugs combination first recommended. NICE points out that these recommendations are based on robust evidence....
Abstract Background STEPWISE is a theory-informed self-management education programme that was co-produced with service users, healthcare professionals and interventionists to support weight loss for people schizophrenia. We report the process evaluation inform understanding about intervention its effectiveness in randomised controlled trial (RCT) evaluated efficacy. Methods Following UK Medical Research Council (MRC) Guidelines developing evaluating complex interventions, we explored...
Aims and method The STEPWISE trial (STructured lifestyle Education for People WIth SchizophrEnia, schizoaffective disorder first episode psychosis) is currently evaluating a education programme in addition to usual care. However, it difficult define what constitutes 'usual care'. We aimed care' management people with schizophrenia, first-episode psychosis study sites. Ten National Health Service (NHS) mental health trusts participated bespoke survey based on the Institute Care Excellence...
Scoliosis is a lateral curvature of the spine with associated rotation, often causing distress due to appearance. For some curves, there good evidence support use spinal brace, worn for 20 24 hours day minimize curve, making it as straight possible during growth, preventing progression. Compliance can be poor appearance and comfort. A night-time eight 12 hours, achieve higher levels curve correction while patients are supine, could preferable patients, but efficacy limited. This protocol...
Abstract Background Increasingly, pragmatic randomised controlled trials are being used to evaluate surgical interventions, although they present particular difficulties in regards recruitment and retention. Methods Procedures processes related implementation of a multi-centre trial discussed. In this trial, forecasting consent rates based on similar micro-costing study activities with research partners were undertaken video was produced targeting recruiting staff the aim aiding recruitment....
Some text in this abstract has been reproduced from Lindsay J, Din S, Hawkey C, Hind D, Irving P, Lobo A, et al. OFR-9 An RCT of autologous stem-cell transplantation treatment refractory Crohn’s disease (low-intensity therapy evaluation): ASTIClite. Gut 2021; 70 (Suppl. 4):A4. Background Treatment-refractory is characterised by chronic symptoms, poor quality life and high costs to the NHS, through days work lost patients. A previous trial haematopoietic stem cell transplant (HSCT) failed its...
Background Over 55,000 spinal operations are performed annually in the NHS. Effective postoperative analgesia facilitates early mobilisation and assists rehabilitation hospital discharge, but is difficult to achieve with conventional, opioid-based, oral analgesia. The clinical cost-effectiveness of two alternative techniques, namely intrathecal opioid more novel erector-spinae plane blockade, unknown. Pain Relief After Instrumented Spinal Surgery (PRAISE) trial aims evaluate these...
<h3>Introduction</h3> Reports of benefit from HSCT were tempered by the ASTIC trial which failed its ambitious primary endpoint and reported high toxicity. Subsequent reports suggest that achieves complete mucosal healing in 50%, toxicity relates to cyclophosphamide dose. <h3>Design</h3> A UK multi-site RCT comparing low intensity with standard care (SOC) patients active CD at endoscopy (SESCD ulcer score ≥ 2) refractory 2 biologic classes. Planned recruitment was 99 randomised 2:1 versus...
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