A5060042123- Cytomegalovirus and herpesvirus research
- Parvovirus B19 Infection Studies
- Immune Response and Inflammation
- Reproductive System and Pregnancy
- Boron Compounds in Chemistry
- Herpesvirus Infections and Treatments
- Ovarian cancer diagnosis and treatment
- Radiopharmaceutical Chemistry and Applications
- interferon and immune responses
- COVID-19 Impact on Reproduction
- Neonatal Health and Biochemistry
- Viral-associated cancers and disorders
- Respiratory viral infections research
- Immune Cell Function and Interaction
- Aortic aneurysm repair treatments
- Virology and Viral Diseases
- Cancer-related molecular mechanisms research
- HIV/AIDS drug development and treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Orthopedic Infections and Treatments
- Pregnancy and preeclampsia studies
- Radioactive element chemistry and processing
- Endometrial and Cervical Cancer Treatments
- Biochemical and Molecular Research
- Biosensors and Analytical Detection
Institute for Medical Biology
2015-2024
Polish Academy of Sciences
2015-2024
Institute of Medical Biology
2018
Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk
2002
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy
1997
Toll-like receptor 9 (TLR9) recognizes non-methylated viral CpG-containing DNA and serves as a pattern recognition that signals the presence of human cytomegalovirus (HCMV). Here, we present genotype distribution single-nucleotide polymorphisms (SNPs) TLR9 gene in infants relationship between HCMV infection. Four (-1237T/C, rs5743836; -1486T/C, rs187084; 1174G/A, rs352139; 2848C/T, rs352140) were genotyped 72 with symptomatic infection 70 healthy individuals. SNP genotyping was performed by...
Abstract Viral and bacterial infections are detected in epithelial ovarian cancer (EOC) tissues. Since the fallopian tubes often affected by pelvic inflammatory disease (PID) majority of serous EOCs appear to originate from dysplastic lesions distal tube, it is relevant consider potential role that infectious agents may play carcinogenesis. We sought analyze prevalence human papillomavirus (HPV) cytomegalovirus (CMV) EOC tissue tube specimens obtained at tumor resection. Ovarian samples...
The antiviral activity of nonfunctionalized gold nanoparticles (AuNPs) against herpes simplex virus type-1 (HSV-1) in vitro was revealed this study. We found that AuNPs are capable reducing the cytopathic effect (CPE) HSV-1 Vero cells a dose- and time-dependent manner when used pretreatment mode. demonstrated within nontoxic concentration range AuNPs. Interestingly, we noted with smaller sizes reduced CPE more effectively than larger ones. observed phenomenon can be tentatively explained by...
Intracellular Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA (dsRNA) and activates antiviral immune responses through the production of type I interferons (IFNs) inflammatory cytokines. This binds to dsRNA molecules produced during human cytomegalovirus (HCMV) replication. TLR7 senses single-stranded (ssRNA) in endosomes, it can interact with endogenous RNAs. We determined genotype distribution single-nucleotide polymorphisms (SNPs) within TLR3 genes children HCMV infection...
The association among specific single-nucleotide polymorphisms (SNPs) in TLR2 (Arg677Trp, Arg753Gln) and TLR4 (Asp299Gln) human cytomegalovirus (CMV) infection was studied infants adults.The were genotyped 151 patients with CMV infections 78 unrelated healthy individuals. Genotyping performed by restriction fragment length polymorphism (RFLP) analysis of PCR-amplified fragments. viral load measured quantitative real-time PCR.Almost all the wild-type homozygotes without polymorphisms. No...
Background Some single nucleotide polymorphisms (SNP), located in Toll-like receptor (TLR) genes, were reported to be associated with human cytomegalovirus (HCMV) infections. The study was aimed assess the correlation of SNPs at TLR4 and TLR9 genes occurrence congenital cytomegaly, based on available samples. Methods Reported case-control included both HCMV infected non-infected fetuses newborns. specimens classified molecular analyses, serological features recent infection DNAemia body...
Abstract Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns and activate innate adaptive immune responses. Single nucleotide polymorphisms (SNPs) within the TLR genes may influence host–pathogen interactions can have an impact on progression of infectious diseases. The present study aimed to investigate genotype distribution TLR2 (2029C/T, rs121917864; 2258G/A, rs5743708), TLR4 (896A/G, rs4986790), TLR9 (− 1237T/C, rs5743836; − 1486T/C, rs187084; 1174G/A, rs352139;...
This study aimed to identify microRNAs (miRNAs) whose expression levels are altered by high-risk human papillomavirus (HR-HPV) infection in women with epithelial ovarian neoplasms. MiRNA was quantified real-time polymerase chain reaction, while HR-HPV DNA using digital-droplet PCR. Analysis of 11 miRNAs demonstrated significantly lower hsa-miR-25-5p HPV-infected compared uninfected tissues (p = 0.0405), differences miRNA corresponding serum were statistically insignificant. The...
Cytomegalovirus (CMV) is a leading cause of congenital infection and infectious hearing loss in children. The ORF UL75 gene encodes envelope glycoprotein H (gH), which essential for CMV entry into host cells the target immune response humans. However, distribution gH variants relationship between viral genotype, load, sequelae children infected with debated. genetic variation isolates from 42 newborns congenitally 93 infants postnatal or unproven was analyzed. Genotyping performed by...
Human parainfluenza virus type 3 (HPIV3), while infecting lower airway epithelial cells induces pneumonia and bronchiolitis in infants children, may lead to asthma exacerbations children adults. Respiratory viruses invading the epithelium activate innate immune response induce inflammatory cytokine release contributing pathophysiology of upper disorders. However, effects HPIV3 infection on nasal have not been well defined. The aim this study was evaluate effect cultured human (HNECs)...
Ovarian cancer (OC) is one of the most common cancers threatening women's lives around world. Epithelial ovarian tumors represent neoplasms. Most OC patients are diagnosed at advanced stage, and there an urgent need to identify novel biomarkers disease. Single-nucleotide polymorphisms (SNPs) in TLR genes may serve as crucial markers susceptibility. We investigated frequency a group 200 women, including 70 with OC. Four SNPs, two each TLR4 (rs4986790 rs4986791) TLR9 (rs187084 rs5743836), were...