A5031988016- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Parvovirus B19 Infection Studies
- Neonatal Health and Biochemistry
- SARS-CoV-2 and COVID-19 Research
- Viral-associated cancers and disorders
- COVID-19 epidemiological studies
- Lymphoma Diagnosis and Treatment
- Polyomavirus and related diseases
- Neonatal Respiratory Health Research
- Vector-borne infectious diseases
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neonatal and Maternal Infections
- Toxoplasma gondii Research Studies
- Vaccine Coverage and Hesitancy
- Infectious Encephalopathies and Encephalitis
- Immune Response and Inflammation
- Zoonotic diseases and public health
- SARS-CoV-2 detection and testing
- Diabetes and associated disorders
- Viral Infections and Immunology Research
- Tuberculosis Research and Epidemiology
- Sepsis Diagnosis and Treatment
Children's Memorial Health Institute
2013-2024
Fondation pour la Recherche Stratégique
2011
Wojewódzki Inspektorat Ochrony Środowiska w Warszawie
2011
Data on the prevalence of SARS-CoV-2 antibody in healthcare workers (HCWs) is scarce, especially pediatric settings. The purpose this study was to evaluate IgG-positivity among HCWs a tertiary hospital. In addition, follow-up serological response subgroup seropositive analysed, gain some insight persistence IgG antibodies SARS-CoV-2. We performed retrospective analysis voluntary testing, which made available free charge Children’s Memorial Health Institute Warsaw (Poland). Plasma samples...
Cytomegalovirus (CMV) is a leading cause of congenital infection and infectious hearing loss in children. The ORF UL75 gene encodes envelope glycoprotein H (gH), which essential for CMV entry into host cells the target immune response humans. However, distribution gH variants relationship between viral genotype, load, sequelae children infected with debated. genetic variation isolates from 42 newborns congenitally 93 infants postnatal or unproven was analyzed. Genotyping performed by...
Cytomegalovirus (CMV) is the most common viral agent of congenital infections and a leading nongenetic cause sensorineural hearing loss (SNHL). The host immunologic factors that render developing foetus prone to intrauterine CMV infection development are unknown. aim this study was assess potential associations between polymorphisms within cytokine receptors genes, risk infection, outcome. A panel 11 candidate single nucleotide (SNPs): TNF rs1799964, rs1800629, TNFRSF1A rs4149570, IL1B...
Cytomegalovirus (CMV) is the most common cause of congenital infection. This pathogen exhibits extensive genetic variability in genes that encode structural envelope glycoproteins, regulatory proteins, and proteins contribute to immune evasion. However, role specific viral strains outcome CMV infection unclear. Variation UL55 gene encoding glycoprotein B (gB), UL144 TNF α-like receptor, US28 β-chemokine receptor was determined 60 newborn infants with 90 postnatal or undefined polymorphisms...
Abstract Human cytomegalovirus (CMV) is a major cause of morbidity in fetuses following intrauterine infection. The glycoprotein (g) envelope trimeric gH/gL/gO and pentameric gH/gL/pUL128/pUL130/pUL131A complexes are required for CMV entry into fibroblasts endothelial/epithelial cells, respectively, both targets neutralizing antibodies. role sequence variability among viral strains the outcome congenital infection controversial. Variation UL75 gene encoding H (gH), UL115 (gL), UL74 (gO),...
Background: Congenital cytomegalovirus (cCMV) infection of the central nervous system (CNS) can cause ventriculomegaly, gliosis, calcifications and cortical defects. Detection CMV DNA in cerebrospinal fluid by PCR (CSF-CMV-PCR) is a marker CNS involvement. Objective: To evaluate diagnostic value positive CSF-CMV-PCR cCMV. Methods: Analysis clinical, laboratory, neuroimaging single-nucleotide polymorphisms (SNPs) data according to results were performed infants with Results: A total 168...
Monitoring of circulating Epstein-Barr virus (EBV) DNA in pediatric transplant patients has been shown to be useful post-transplant patient management. It still remains unclear which blood sample type is more suitable, and how EBV levels whole (WB) correlate with those peripheral mononuclear cells (PBMCs). The aim this study was compare load WB PBMCs recipients. After liver, kidney, or combined liver-kidney transplantation, 172 matched samples were collected from 84 children (130 42...
A retrospective observational study was conducted among healthcare workers (HCWs) in a tertiary paediatric hospital. The covered the period before and after implementation of vaccination programme evaluated incidence new SARS-CoV-2 infections both periods. Risk factors infection COVID-19 vaccine effectiveness also assessed real-world setting. overall HCWs 19.4% with high proportion asymptomatic individuals (45.1%). 16.6% nurses had higher risk infection, while physicians reduced (OR 1.80,...
Congenital cytomegalovirus (cCMV) infection is the most common intrauterine infection. A non-specific immune response first line of host defense mechanism against human (HCMV). There limited data on associations between Single Nucleotide Polymorphisms (SNPs) in genes involving innate immunity and risk clinical manifestation cCMV The aim study was to investigate association selected SNPs encoding cytokines cytokine receptors, predisposition including symptomatic course disease symptoms. panel...
Background.Antiviral treatment is recommended for symptomatic newborns with congenital cytomegalovirus infection (cCMV).Objectives.To compare 2 methods in neonates cCMV -ganciclovir-based therapy (intravenous ganciclovir (GCV) or sequential GCV + valganciclovir (VGCV) therapy) oral VGCV-based -in Polish neonates. Material and methods.A total of 98 infants (positive HCMV DNA urine ≤21 st day life) hospitalized the neonatal intensive care unit (NICU) between 2012 2017 were enrolled.Clinical...
Gregorek H, Jankowska I, Dzierżanowska-Fangrat K, Teisseyre J, Sawicka A, Kasztelewicz B, Pawłowska J. Long-term monitoring of Epstein–Barr virus DNA load and humoral parameter abnormalities in pediatric liver transplant recipients before development malignancy. Pediatr Transplantation 2010: 14:629–635. © 2010 John Wiley & Sons A/S. Abstract: EBV loads responses were monitored 51 as a proposed non-invasive laboratory tool for early detection changes preceding severe clinical complications....
Immunosuppressed pediatric transplant recipients are at risk of developing Epstein-Barr virus (EBV)-associated complications (such as post-transplant lymphoproliferative disorders). Monitoring the EBV DNA level in blood alone has a low predictive value for course infection and its complications. Therefore, additional prognostic markers widely sought. The study aim was to analyze gene expression patterns LMP1 polymorphism relation levels liver recipients. load measurement, variant, analysis...
The aim of the present study was to investigate serum levels novel markers: interleukin 17A (IL-17A), anaphylatoxin C5a and chemokine regulated upon activation normal T-cell expressed secreted (RANTES) in neonates with clinically suspected early-onset neonatal sepsis (EONS), compare their values those non-infected neonates. Eighteen clinical signs symptoms EONS were enrolled this study. Fifty healthy, served as control group. In all IL-17A, RANTES measured by solid-phase sandwich...
There are limited data on factors that determine viral load (VL) in congenital cytomegalovirus (cCMV) infection. Single nucleotide polymorphisms (SNPs) might influence individual host response to This study aimed investigate the association between SNPs genes encoding cytokines or cytokine receptors and VL newborns with cCMV.Eight (IL1B rs16944, IL12B rs3212227, IL28B rs12979860, CCL2 rs1024611, DC-SIGN rs735240, TLR2 rs5743708, TLR4 rs4986791 TLR9 rs352140) were analyzed population of 233...
Abstract Data on prevalence of SARS-CoV-2 antibody in healthcare workers (HCWs) is scare, especially pediatric settings. The purpose this study was to evaluate the IgG-positivity among HCWs a tertiary hospital. In addition, follow-up serological response subgroup seropositive performed, get some insight persistence IgG antibodies SARS-CoV-2. Free, voluntary testing made available Children’s Memorial Health Institute Warsaw (Poland). Plasma samples were collected between July 1 and August 9,...
Abstract A retrospective observational study was conducted among healthcare workers (HCWs) in a tertiary paediatric hospital. The covered the period before and after implementation of vaccination programme evaluated incidence new SARS-CoV-2 infections both periods. Risk factors infection COVID-19 vaccine effectiveness also assessed real-world setting. overall HCWs 19.4% with high proportion asymptomatic individuals (45.1%). 16.6% nurses had higher risk infection, while physicians reduced (OR...
Lyme Neuroborreliosis (LNB) â Clinical and Diagnostic Difficulties - Dorota Dunin-WÄ sowicz, Beata Kasztelewicz, Katarzyna Tomaszek, Alicja PawiÅska, Janusz KsiÄ Å¼yk, Anna Wieteska-Klimczak, Elżbieta Jurkiewicz, Dzierżanowska-Fangrat