A5046292075- Inflammasome and immune disorders
- interferon and immune responses
- Respiratory viral infections research
- RNA and protein synthesis mechanisms
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Immune cells in cancer
- Transplantation: Methods and Outcomes
- Influenza Virus Research Studies
- RNA Research and Splicing
- RNA modifications and cancer
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- Biotin and Related Studies
- Fungal and yeast genetics research
- Mycobacterium research and diagnosis
Boston Children's Hospital
2020-2024
Harvard University
2020-2024
University of Milano-Bicocca
2020-2022
Boston University
2021-2022
MRC Laboratory of Molecular Biology
2017
Interferons interfere with lung repair (IFNs) are central to antiviral immunity. Viral recognition elicits IFN production, which in turn triggers the transcription of IFN-stimulated genes (ISGs), engage various functions. Type I IFNs (IFN-α and IFN-β) widely expressed can result immunopathology during viral infections. By contrast, type III (IFN-λ) responses primarily restricted mucosal surfaces thought confer protection without driving damaging proinflammatory responses. Accordingly, IFN-λ...
Severe coronavirus disease 2019 (COVID-19) is characterized by overproduction of immune mediators, but the role interferons (IFNs) type I (IFN-I) or III (IFN-III) families remains debated. We scrutinized production IFNs along respiratory tract COVID-19 patients and found that high levels IFN-III, to a lesser extent IFN-I, characterize upper airways with viral burden reduced risk severity. Production specific not members denotes mild pathology efficiently drives transcription genes protect...
Abstract Lower respiratory tract infections are a leading cause of mortality driven by infectious agents. RNA viruses such as influenza virus, syncytial virus and the new pandemic coronavirus SARS-CoV-2 can be highly pathogenic. Clinical experimental evidence indicate that most severe lethal cases do not depend on viral burden are, instead, characterized an aberrant immune response. In this work we assessed how innate response contributes to pathogenesis infections. We demonstrate type III...
Summary The COVID-19 outbreak driven by SARS-CoV-2 has caused more than 2.5 million deaths globally, with the most severe cases characterized over-exuberant production of immune-mediators, nature which is not fully understood. Interferons type I (IFN-I) or III (IFN-III) families are potent antivirals, but their role in remains debated. Our analysis gene and protein expression along respiratory tract shows that IFNs, especially IFN-III, over-represented lower airways patients COVID-19, while...
Spliceosomal proteins Hsh49p and Cus1p are components of SF3b, which together with SF3a, Msl1p/Lea1p, Sm proteins, U2 snRNA, form snRNP, plays a crucial role in pre-mRNA splicing. Hsh49p, comprising two RRMs, forms heterodimer Cus1p. We determined the crystal structures Saccharomyces cerevisiae full-length as well its RRM1 complex minimal binding region (residues 290–368). The show that Cus1 fragment binds to α-helical surface RRM1, opposite four-stranded β-sheet, leaving canonical...
Abstract Tissue damage and repair are hallmarks of the inflammatory process. Despite a wealth information focused on mechanisms that govern tissue damage, mechanistic insight how immune mediators affect restitution phase is lacking. Here, we investigated interferons influence after intestinal mucosa driven by or physical injury. We found type III, but not I, serve central role in Type III induce upregulation ZBP1, caspase activation, cleavage gasdermin C, drive epithelial cell death...