A5078171780- Cancer Research and Treatments
- Salmonella and Campylobacter epidemiology
- Inflammasome and immune disorders
- Immune cells in cancer
- interferon and immune responses
- DNA Repair Mechanisms
- Vibrio bacteria research studies
- IL-33, ST2, and ILC Pathways
- Bacteriophages and microbial interactions
- Immune Response and Inflammation
Centre d’Immunologie de Marseille-Luminy
2022-2024
Aix-Marseille Université
2022-2024
Centre National de la Recherche Scientifique
2022
Inserm
2022
Infectiologie Animale et Santé Publique
2017-2020
Université de Tours
2017
Institut National de la Recherche Agronomique
2017
Salmonella Typhimurium expresses on its outer membrane the protein Rck which interacts with epidermal growth factor receptor (EGFR) of plasma targeted host cells. This interaction activates signaling pathways, leading to internalization Salmonella. Since EGFR plays a key role in cell proliferation, we sought determine influence mediated infection cycle. By analyzing DNA content uninfected and infected cells using flow cytometry, showed that Rck-mediated induced delay S-phase (DNA replication...
Abstract Tissue damage and repair are hallmarks of the inflammatory process. Despite a wealth information focused on mechanisms that govern tissue damage, mechanistic insight how immune mediators affect restitution phase is lacking. Here, we investigated interferons influence after intestinal mucosa driven by or physical injury. We found type III, but not I, serve central role in Type III induce upregulation ZBP1, caspase activation, cleavage gasdermin C, drive epithelial cell death...