A5082001704- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Inflammatory Biomarkers in Disease Prognosis
- Immunotherapy and Immune Responses
- COVID-19 and healthcare impacts
- COVID-19 Impact on Reproduction
- Cancer Immunotherapy and Biomarkers
- Genetics and Neurodevelopmental Disorders
- Animal Virus Infections Studies
- Coronary Artery Anomalies
- Congenital heart defects research
- Helminth infection and control
- Drug Transport and Resistance Mechanisms
- Phagocytosis and Immune Regulation
- Statistical Methods in Epidemiology
- Viral gastroenteritis research and epidemiology
- Vitamin C and Antioxidants Research
- SARS-CoV-2 detection and testing
- Infant Nutrition and Health
- Mind wandering and attention
- Child Nutrition and Water Access
- Cancer, Stress, Anesthesia, and Immune Response
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2020-2025
Azienda Ospedaliero Universitaria Maggiore della Carita
2020-2025
Ospedale Sacro Cuore Don Calabria
2016-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2024
Université d'Artois
2021
Istituto Pediatrico della Svizzera Italiana
2018
Ospedale San Giovanni Bellinzona
2018
Office Médico Pédagogique
2012
University of Geneva
2012
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
2009
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to nearly every continent, registering over 1,250,000 deaths worldwide. effects of SARS-CoV-2 on host targets remains largely limited, hampering our understanding Coronavirus Disease 2019 (COVID-19) pathogenesis and the development therapeutic strategies. present study used a comprehensive untargeted metabolomic lipidomic approach capture response infection. We found that several circulating lipids acted as...
The COVID-19 pandemic has stimulated the search for effective preventive and therapeutic agents. In recent years, many studies have considered effects of different nutrients. This study aimed to investigate association between serum monolaurin levels risk developing among healthcare workers. this prospective observational cohort study, 2712 workers from University Hospital “Maggiore della Carità” in Novara, Italy were enrolled. Participants underwent blood sampling followed up six months...
To assess the antibody response to BNT162b2 mRNA COVID-19 vaccine in a cohort of health-care workers (HCW), comparing individuals with previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and SARS-CoV-2-naive individuals.HCW were tested at T0 (day first dose), T1 second dose) T2 (2-3 weeks after for IgG anti-nucleocapsid protein, IgM anti-spike protein anti-receptor binding domain (IgG-RBD-S). The was compared between four main groups: group A, positive antibodies...
Understanding the cause of sex disparities in COVID-19 outcomes is a major challenge. We investigate hormone levels and their association with patients, stratified by age. This observational, retrospective, cohort study included 138 patients aged 18 years or older COVID-19, hospitalized Italy between February 1 May 30, 2020. The hormones (testosterone, estradiol, progesterone, dehydroepiandrosterone) (ARDS, severe in-hospital mortality) was explored 120 50 over. STROBE checklist followed....
As lactoferrin is a nutritional supplement with proven antiviral and immunomodulatory abilities, it may be used to improve the clinical course of COVID-19. The efficacy safety bovine were evaluated in LAC randomized double-blind placebo-controlled trial. A total 218 hospitalized adult patients moderate-to-severe COVID-19 receive 800 mg/die oral (n = 113) or placebo 105), both given combination standard therapy. No differences vs. observed primary outcomes: proportion death intensive care...
The COVID-19 pandemic is still raging in most countries. Although the recent mass vaccination campaign has opened a new chapter battle against SARS-CoV-2, world far from herd immunity. There an urgent need to identify healthy people at high risk of contracting COVID-19, as well supplements and nutraceuticals that can reduce infection or mitigate symptoms. In present study, metabolic phenotype could protect individuals SARS-CoV-2 predispose them developing was investigated. Untargeted...
The Coronavirus disease (COVID-19) outbreak is putting the European National Health Systems under pressure. Interestingly, Emergency Department (ED) referrals for other reasons than COVID-19 seem to have declined steeply. In present paper, we aimed verify how changed ED referral pattern.We retrospectively reviewed clinical records of patients referred a University Hospital in Northern Italy from 1 March 13 April 2020. We compared following data with those belonging same period 2019: number...
Background. SARS-CoV-2 is responsible for COVID-19, a clinically heterogeneous disease, ranging from being completely asymptomatic to life-threating manifestations. An unmet clinical need the identification at disease onset or during its course of reliable biomarkers allowing patients’ stratification according severity. In this observational prospective cohort study, immunologic and laboratory signatures were analyzed identify independent predictors unfavorable (either death intensive care...
The differential diagnosis of hepatic cystic echinococcosis (CE) may be challenging. When imaging is insufficient, serology can applied, but no consensus diagnostic algorithm exists. We evaluated the performances nine serological tests commercialized in Europe for “echinococcosis”. performed a accuracy study using panel sera from patients with CE (n = 45 “liquid” content stages, n 25 “solid” stages) and non-CE focal liver lesions 54 content, 11 content). staging were based on ultrasound...
Vaccines are the most effective means to prevent potentially deadly effects of SARS-CoV-2 infection, but not all vaccinated individuals gain same degree protection. Patients undergoing chronic immunosuppressive therapy due autoimmune diseases or liver transplants, for example, may show impaired anti-SARS-CoV-2 antibody response after vaccination. We performed a prospective observational study with parallel arms, aiming (a) evaluate seroconversion mRNA vaccine administration in different...
More than three years have passed since the first case, and COVID-19 is still a health concern, with several open issues such as lack of reliable predictors patient’s outcome. Osteopontin (OPN) involved in inflammatory response to infection thrombosis driven by chronic inflammation, thus being potential biomarker for COVID-19. The aim study was evaluate OPN predicting negative (death or need ICU admission) positive (discharge and/or clinical resolution within 14 days hospitalization) We...
Some serology assays demonstrated useful for post-treatment monitoring of
Reliable biomarkers allowing early patients’ stratification for the risk of adverse outcomes in COVID-19 are lacking. Gas6, together with its tyrosine kinase receptors named TAM, is involved regulation immune homeostasis, fibrosis, and thrombosis. Our aim was to evaluate whether sAxl, sMerTK could represent predictors disease evolution either towards a negative (death or need ICU admission) positive (discharge and/or clinical resolution within first 14 days hospitalization) outcome. To this...
SARS-CoV-2 is a single-stranded RNA virus, known to be the causative agent of COVID-19. As resulting disease shows very heterogeneous range clinical manifestations, identification early biomarkers allowing patients stratification according expected severity still an unmet need.In this observational prospective cohort study, 137 consecutive patients, testing positive for infection by nasopharyngeal swab RT-PCR or antigenic test, were enrolled evaluate their plasma viral load at time...
SARS-CoV-2 is the etiological agent of COVID-19, an extremely heterogenous disease that can cause severe respiratory failure and critical illness. To date, reliable biomarkers allowing for early patient stratification according to severity are still lacking. Calcitonin gene-related peptide (CGRP) a vasoactive neuropeptide involved in lung pathophysiology immune modulation poorly investigated COVID-19 context. In this observational, prospective cohort study, we correlation between CGRP...
Currently approved vaccines are highly effective in protecting against hospitalization and severe COVID-19 infections. How pre-existing immunity responds to new variants with mutated antigens is crucial information for elucidating the functional interplay between antibodies B T cell responses during infection SARS-CoV-2 variants.
Strongyloidiasis, a nematode infection which is mainly caused by Strongyloides stercoralis in humans, can lead to fatal syndrome immunocompromised individuals. Its diagnosis challenging due the absence of diagnostic gold standard. The highly prevalent migrants from endemic countries tropical and subtropical areas, rapid test would be helpful for screening purposes. aim this study was estimate accuracy novel immunochromatographic (ICT) S. infection.A single-centre undertaken using...
A relevant proportion of immunocompromised patients did not reach a detectable seroconversion after full primary vaccination cycle against SARS-CoV-2. The effect different immunosuppressants and the potential risks for SARS-CoV-2 infection in these subjects is largely unknown. Patients from Rivalsa prospective, observational cohort study with planned anti third dose mRNA between October December 2021 were asked to participate this follow-up study. about eventual confirmed positivity within 6...
Background: Dried blood spots (DBS) are used for epidemiological surveys on infectious diseases in settings where limited resources available. In fact, DBS can help to overcome logistic difficulties the collection, transport and storage of biological specimens. Objective: To evaluate accuracy Strongyloides stercoralis serology performed DBS. Methods: A survey was proposed children attending a school village Borbon, Ecuador, their parents/guardians. Each participant gave consent collection...