A5101704843- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Fish Ecology and Management Studies
- Zebrafish Biomedical Research Applications
- Nicotinic Acetylcholine Receptors Study
- Neurotransmitter Receptor Influence on Behavior
- Dysphagia Assessment and Management
- Microplastics and Plastic Pollution
- Neuropeptides and Animal Physiology
- Estrogen and related hormone effects
- Caching and Content Delivery
- Traditional Chinese Medicine Studies
- Cancer Mechanisms and Therapy
- Transcranial Magnetic Stimulation Studies
- Neonatal skin health care
- Carbon and Quantum Dots Applications
- Traditional Chinese Medicine Analysis
- Diverse Interdisciplinary Research Innovations
- Reproductive biology and impacts on aquatic species
- Pharmaceutical and Antibiotic Environmental Impacts
- Animal Ecology and Behavior Studies
- Marine Sponges and Natural Products
- Natural Compounds in Disease Treatment
Shanxi University
2024
University of Chinese Academy of Sciences
2024
Yantai Institute of Coastal Zone Research
2023-2024
Chinese Academy of Sciences
2023-2024
Yantai University
2023-2024
Soochow University
2024
First Affiliated Hospital of Soochow University
2024
West China Medical Center of Sichuan University
2018-2021
Nanjing Medical University
2018-2020
Jiangsu Province Hospital
2018-2020
Levodopa-induced dyskinesias are common motor complication of Parkinson's disease after 4-6 years treatment. The hallmarks include unilateral onset and the tendency to appear on more affected body sides. There is a growing literature documenting lateralization abnormalities associated with emergence dyskinesias. Our investigation aimed explore interhemispheric functional its corresponding morphological asymmetry. A total 22 dyskinetic patients, 23 nondyskinetic 26 controls were enrolled....
A series of behavioral detection paradigms have been developed for zebrafish (Danio rerio) to examine anxiety-like responses. Among them, the novel tank diving test is rapidly gaining popularity in translational neuroscience and research investigation psychopharmacological activity focusing on stress. Zebrafish respond conspecific epidermal-released alarm substances with antipredator reactions. Although responses were well characterized a experiment, relationship between intensity behavior...
The purpose of this study was to assess the efficacy zishentongluo (ZSTL) for treatment diabetic nephropathy (DN) and its related mechanisms. Forty-five patients with DN were randomized receive either ZSTL (n = 25) or benazepril 20), an angiotensin converting enzyme inhibitor, 12 weeks. Conventional biochemical tests performed determine fasting blood glucose (FBG), glycated hemoglobin (HbA1c), serum creatinine (SCr), endogenous clearance rate (Ccr), total cholesterol (TC), triglyceride (TG)...
More and more evidence suggests that dopamine receptor D3 gene (DRD3) plays an important role in the clinical manifestations treatment of Parkinson's disease (PD). DRD3 Ser9Gly polymorphism is most frequently studied variant point. Our aim was to investigate potential effect on modulating resting-state brain function associative PD patients. We consecutively recruited 61 idiopathic patients 47 healthy controls (HC) who were evaluated by scales, genotyped for DRD3, underwent functional...
Summary Aims We aimed to explore effects of bone marrow stromal cell antigen‐1 (BST1) rs4698412 allelic variant on brain activation and associative clinical symptoms in Parkinson’s disease (PD). Methods A total 49 PD patients 47 healthy control (HC) subjects were recruited for evaluations, blood samples collection genotypes, resting‐state functional MRI (rs‐fMRI) scans. Based BST1 (G → A), participants further divided into 18 PD‐GG, 31 PD‐GA/AA, 20 HC‐GG, 27 HC‐GA/AA carriers, which...
Alterations in brain function Parkinson's disease (PD) patients with diphasic dyskinesia have not been investigated. We aimed to explore the alterations regional function. Each of 53 levodopa (LD)-treated PD had two resting-state functional magnetic resonance imaging (rs-fMRI) scans same morning, before and after taking LD. The homogeneity (ReHo) approach was used reveal local synchronization changes. Two-way factorial repeated measures analysis covariance, group as a between-subject factor...
Abnormal dopaminergic modulation of the cortico-basal ganglia motor loops results in emergence levodopainduced dyskinesia (LID).We focused on alterations gray matter (GM) volume and cortical thickness brain, especially loops, Parkinson's disease (PD) with diphasic dyskinesia.48 PD patients dyskinesia, 60 without 48 healthy controls (HC) were included.Voxel-based morphometry (VBM) was applied to get GM images from MRI brain images.FreeSurfer used thickness.Distinct analyses covariance...
Environmentally cued hatching is prevalent, diverse, and crucial to many animals’ survival. Fish embryos use a variety of chemical cues initiate avoid potential predators, yet the function released from predatory consumption heterospecific prey largely unknown. Zebra cichlids (Metriaclima estherae) are ferocious predators that can feed on medaka (Oryzias latipes), though it impossible for this occur in their natural habitat. Zebrafish (Danio rerio) have been employed as experimental subjects...
Recent research suggests that starfish secondary metabolites possess antifouling and antifeedant properties play a role in biological interactions various ecological functions. Previous demonstrated saponins from exert their toxic effects on fish by interacting with cell membrane cholesterol. This study investigated the hypothesis metabolites, other than saponins, Asterias amurensis may be harmful to eggs, particularly marine medaka (Oryzias melastigma) which share habitat. We systematically...
Aims We sought to explore the role of SLC6A3 rs393795 allelic variant in cerebral spontaneous activity and clinical features Parkinson’s disease (PD) via imaging genetic approach. Methods Our study recruited 50 PD 45 healthy control (HC) participants provide clinical, genetic, resting state functional magnetic resonance (rs-fMRI) data. All subjects were separated into 16 PD-AA, 34 PD-CA/CC, 14 HC-AA, 31 HC-CA/CC four subgroups according genotyping. Afterwards, main effects interactions...
With the rapid development of economy, shortage water resources became more serious at eastern Handan city, it is important to allocate limited reasonably. Based on multi-objective planning theory, building up model optimal allocation resources. The goal targeted maximum benefits society and environment, which solved by PSO, acquire program different guaranteed rate in 2030, supply basis for management. results show that PSO feasible allocation.
Background: More and more evidence suggests that dopamine receptor D3 gene (DRD3) plays an important role in the clinical manifestations treatment of Parkinson's disease (PD). DRD3 Ser9Gly polymorphism is most frequently studied variant point. Our aim was to investigate potential effect on modulating resting-state brain function associative PD patients.