A5053446867- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Advanced Neuroimaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cerebral Venous Sinus Thrombosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Bipolar Disorder and Treatment
- RNA regulation and disease
- Stroke Rehabilitation and Recovery
- Cancer Cells and Metastasis
- MRI in cancer diagnosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Breast Lesions and Carcinomas
- Cancer-related molecular mechanisms research
- Genetic Neurodegenerative Diseases
- Electrochemical Analysis and Applications
- Plant Reproductive Biology
- Immune cells in cancer
- Medical Imaging and Analysis
- Epigenetics and DNA Methylation
- Eicosanoids and Hypertension Pharmacology
Nanjing Medical University
2018-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2023
Peking Union Medical College Hospital
2022-2023
Jiangsu Province Hospital
2018-2022
Hebei Medical University
2021
81th Hospital of PLA
2013
Abstract Aims The aim of this study was to clarify the dynamic neural activity levodopa‐induced dyskinesia (LID) in Parkinson's disease (PD). Methods Using functional network connectivity (dFNC) analysis, we evaluated 41 PD patients with LID (LID group) and 34 without (No‐LID group). Group spatial independent component analysis sliding‐window approach were employed. Moreover, applied a k‐means clustering algorithm on windowed (FC) matrices identify reoccurring FC patterns (i.e., states)....
Levodopa-induced dyskinesias are common motor complication of Parkinson's disease after 4-6 years treatment. The hallmarks include unilateral onset and the tendency to appear on more affected body sides. There is a growing literature documenting lateralization abnormalities associated with emergence dyskinesias. Our investigation aimed explore interhemispheric functional its corresponding morphological asymmetry. A total 22 dyskinetic patients, 23 nondyskinetic 26 controls were enrolled....
Abstract Background and purpose The development of high‐resolution magnetic resonance imaging (HR‐MRI) has enabled submillimeter‐level evaluation intracranial artery plaque luminal thrombus. We sought to investigate the value HR‐MRI in assessing pathogenesis acute Methods examined presence thrombus on three‐dimensional T1‐weighted ischemic stroke patients with occlusion angiography. defined two thrombus‐related features (peri‐thrombus distal residual flow beyond thrombus) analyzed their...
More and more evidence suggests that dopamine receptor D3 gene (DRD3) plays an important role in the clinical manifestations treatment of Parkinson's disease (PD). DRD3 Ser9Gly polymorphism is most frequently studied variant point. Our aim was to investigate potential effect on modulating resting-state brain function associative PD patients. We consecutively recruited 61 idiopathic patients 47 healthy controls (HC) who were evaluated by scales, genotyped for DRD3, underwent functional...
Alterations in brain function Parkinson's disease (PD) patients with diphasic dyskinesia have not been investigated. We aimed to explore the alterations regional function. Each of 53 levodopa (LD)-treated PD had two resting-state functional magnetic resonance imaging (rs-fMRI) scans same morning, before and after taking LD. The homogeneity (ReHo) approach was used reveal local synchronization changes. Two-way factorial repeated measures analysis covariance, group as a between-subject factor...
Abnormal dopaminergic modulation of the cortico-basal ganglia motor loops results in emergence levodopainduced dyskinesia (LID).We focused on alterations gray matter (GM) volume and cortical thickness brain, especially loops, Parkinson's disease (PD) with diphasic dyskinesia.48 PD patients dyskinesia, 60 without 48 healthy controls (HC) were included.Voxel-based morphometry (VBM) was applied to get GM images from MRI brain images.FreeSurfer used thickness.Distinct analyses covariance...
Intracranial atherosclerotic stenosis (ICAS) is one of the leading causes stroke worldwide. Current diagnostic evaluations and treatments remain insufficient to assess vulnerability intracranial plaques reduce recurrence in symptomatic ICAS. On other hand, asymptomatic ICAS associated with an increased risk cognitive impairment. The pathogenesis related decline largely unknown. aim SICO-ICAS study (stroke incidence outcomes ICAS) elucidate pathophysiology impairment population,...
Objective To sum up nursing experience of cerebrospinal fluid drainage in patients with aortic dissection paraplegia after sun′s operation. Methods Retrospective analysis 17 cases clinical care from January 2014 to December 2016, summing related includingintensive drainage, observation limb movement and muscle strength, monitoring complications, maintain stable hemodynamics, strengthen the life during hospitalization, order ensure fluid. Results 2 deaths, Recovery different...
Background: More and more evidence suggests that dopamine receptor D3 gene (DRD3) plays an important role in the clinical manifestations treatment of Parkinson's disease (PD). DRD3 Ser9Gly polymorphism is most frequently studied variant point. Our aim was to investigate potential effect on modulating resting-state brain function associative PD patients.
Abstract Background Traditional measures of static functional connectivity may not completely reflect the dynamic neural activity levodopa-induced dyskinesia (LID) in Parkinson's disease (PD). This study was aimed to investigate changes large-scale network temporal domain PD patients with and without LID. Methods Using (dFNC) analysis, we evaluated 41 LID (LID group) 34 (No-LID group), on off their levodopa medications. Group spatial independent component sliding-window approach k-means...