A5022249999- HIV Research and Treatment
- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- Epigenetics and DNA Methylation
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Political Economy and Marxism
- Cytomegalovirus and herpesvirus research
- Genetics and Neurodevelopmental Disorders
- Political Philosophy and Ethics
- Autism Spectrum Disorder Research
- Mosquito-borne diseases and control
- Bipolar Disorder and Treatment
- Pharmacological Effects and Toxicity Studies
- Identity, Memory, and Therapy
- Political Theory and Influence
- Epilepsy research and treatment
- Dietary Effects on Health
- Infectious Encephalopathies and Encephalitis
- Rousseau and Enlightenment Thought
- Maternal Mental Health During Pregnancy and Postpartum
- Birth, Development, and Health
- Nuclear Receptors and Signaling
- Nanocluster Synthesis and Applications
University of California, Los Angeles
2015-2024
New York University
2023
The Alfred Hospital
2023
South African Medical Research Council
2020
Denver Public Health
2019
Johns Hopkins University
2015-2019
State University of New York
2019
The University of Texas Health Science Center at Houston
2019
Rush University Medical Center
2019
University of Pittsburgh
2015-2019
Background. Infection with human immunodeficiency virus type 1 (HIV) is associated clinical symptoms of accelerated aging, as evidenced by the increased incidence and diversity age-related illnesses at relatively young ages supporting findings organ cellular pathologic analyses. But it has been difficult to detect an aging effect a molecular level.
<h3>Objective:</h3> To evaluate the frequency of HIV-associated neurocognitive disorder (HAND) in HIV+ individuals and determine whether HAND changed over 4 years follow-up. <h3>Methods:</h3> The Multicenter AIDS Cohort Study (MACS) is a prospective study gay/bisexual men. Beginning 2007, all MACS participants received full neuropsychological test battery functional assessments every 2 to allow for classification. <h3>Results:</h3> 364 seen 2007–2008 was 33% 197 at time periods during...
Although most agree that poor adherence to antiretrovirals is a common problem, relatively few factors have been shown consistently predict treatment failure. In this study, theoretical framework encompassing demographic characteristics, health beliefs/attitudes, self-efficacy, and neurocognitive status was examined in relationship highly active antiretroviral therapy adherence.
Individuals with psychiatric disorders have elevated rates of autoimmune comorbidity and altered immune signaling. It is unclear whether these immunological states a shared genetic basis those disorders. The present study sought to use existing summary-level data from previous genome-wide association studies determine if commonly varying single nucleotide polymorphisms are between immune-related phenotypes. We estimated heritability examined pair-wise correlations using the linkage...
Using DNA methylation profiles (
The National NeuroAIDS Tissue Consortium (NNTC) performed a brain gene expression array to elucidate pathophysiologies of Human Immunodeficiency Virus type 1 (HIV-1)-associated neurocognitive disorders.Twenty-four human subjects in four groups were examined A) Uninfected controls; B) HIV-1 infected with no substantial impairment (NCI); C) Infected NCI without HIV encephalitis (HIVE); D) and HIVE. RNA from neocortex, white matter, neostriatum was processed the Affymetrix® platform.With HIVE...
ABSTRACT Aging is often perceived as a degenerative process resulting from random accrual of cellular damage over time. Despite this, age can be accurately estimated by epigenetic clocks based on DNA methylation profiles almost any tissue the body. Since such pan-tissue have been successfully developed for several different species, we hypothesized that one build pan-mammalian measure in all mammalian species. To address generated data using 11,754 arrays, each profiling up to 36 thousand...
Recent studies demonstrate that infection with the HIV-1 is associated accelerated aging effects in adults according to a highly accurate epigenetic biomarker of known as clock. However, it not yet whether age acceleration occurs early adolescence perinatally HIV-infected (PHIV+) youth.
Clinicians and researchers who use neuropsychological tests to track functioning over time are in need of a method correct for the effects practice. Drawing from large database healthy, male subjects, we present data that can be used calculate predicted retest scores eight widely instruments either via simple regression or reliable change index (RCI) methods. These methods useful individuals assessed across wide interval, 4–24 months. Limitations discussed regarding applicability data. Those...
The apolipoprotein E (APOE) ε4 allele enhances cerebral accumulation of β-amyloid (Aβ) and is a major risk factor for sporadic Alzheimer's disease. We hypothesized that HIV-associated neurocognitive disorders (HAND) would be associated with the APOE genotype Aβ deposition.Clinicopathological study HIV-infected adults from four prospective cohorts in US National NeuroAIDS Tissue Consortium.We used multivariable logistic regressions to model outcomes [Aβ plaques (immunohistochemistry) HAND...
Over the past two decades, there has been a significant amount of research investigating risks and benefits hormone replacement therapy (HRT) with regards to neurodegenerative disease. Here, we review basic science studies, randomized clinical trials, epidemiological discuss putative neuroprotective effects HRT in context Alzheimer's disease, Parkinson's frontotemporal dementia, HIV-associated neurocognitive disorder. Findings date suggest reduced risk disease improved cognitive functioning...
Human Immunodeficiency Virus-1 (HIV) infection frequently results in neurocognitive impairment. While the cause remains unclear, recent gene expression studies have identified genes whose transcription is dysregulated individuals with HIV-association disorder (HAND). However, methods for interpretation of such data lagged behind technical advances allowing decoding genetic material. Here, we employ systems biology novel to field NeuroAIDS further interrogate extant transcriptome derived from...
Young blood plasma is known to confer beneficial effects on various organs in mice and rats. However, it was not whether from young adult pigs rejuvenates old rat tissues at the epigenetic level; alters clock, which a highly accurate molecular biomarker of aging. To address this question, we developed validated six different clocks for that are based DNA methylation values derived n = 613 tissue samples. As indicated by their respective names, pan-tissue clock can be applied profiles all...
Reconstructing Marxismexplores fundamental questions about the structure of Marxist theory and its prospects for future. The authors maintain that disintegration old theoretical unity classical Marxism is in part responsible what commonly called crisis Marxism. Only a reconstructed can come to terms with this disintegration. Addressing range problems historical materialism class analysis, compare Darwinian evolutionary theory, identify distinctively Marx s history. Through an evaluation G.A....
Decision making was assessed using a laboratory gambling task in 67 adults with the Human Immunodeficiency Virus (HIV+) and 19 HIV-seronegative (HIV-) control participants.Neurocognitive test performance across several domains also analyzed to examine potential cognitive mechanisms of performance.As predicted, HIV+ group performed worse on task, indicating greater risky decision making.Specifically, selected more cards from "risky" or disadvantageous deck that included relatively large...
Abstract Due to similar routes of viral transmission, many individuals infected with the human immunodeficiency virus (HIV) are also hepatitis C (HCV). Each can cause cognitive compromise among mono-infected individuals; evidence is accumulating that HIV/HCV co-infection may have a particularly deleterious impact on cognition. We present neuropsychological data obtained from 118 HIV+ adults advanced HIV disease, 35 whom were co-infected HCV, who completed comprehensive neurocognitive...
The Multicenter AIDS Cohort Study (MACS) is one of the largest and longest running studies natural treated history HIV disease. Neuropsychological (NP) substudy was begun in 1988 following reports significant adverse neurological consequences disease, including dementia. goal to characterize neuropsychological deficits among individuals with track complications over time. There were three distinct MACS recruitment stages that focused on different groups HIV-infected men, or men at risk for...
Abstract Young blood plasma is known to confer beneficial effects on various organs in mice. However, it was not whether young rejuvenates cells and tissues at the epigenetic level; alters clock, which a highly-accurate molecular biomarker of aging. To address this question, we developed validated six different clocks for rat that are based DNA methylation values derived from n=593 tissue samples. As indicated by their respective names, pan-tissue clock can be applied profiles all tissues,...
Epigenetic clocks based on patterns of DNA methylation have great importance in understanding aging and disease; however, there are basic questions to be resolved their application. It remains unknown whether epigenetic age acceleration (EAA) within an individual shows strong correlation between different primary tissue sites, the extent which pathology clinical illness correlate with EAA target organ, if variability across tissues differs according sex. Considering outsized role age-related...