A5043422740- Antimicrobial Peptides and Activities
- Reproductive Physiology in Livestock
- Antimicrobial agents and applications
- Pediatric health and respiratory diseases
- Protein Hydrolysis and Bioactive Peptides
- Genetic and phenotypic traits in livestock
- Reproductive Biology and Fertility
- Biochemical and Structural Characterization
- Antibiotic Resistance in Bacteria
- Inhalation and Respiratory Drug Delivery
- Invertebrate Immune Response Mechanisms
- Science and Education Research
- Reproductive System and Pregnancy
- Veterinary Equine Medical Research
- RNA and protein synthesis mechanisms
- Cystic Fibrosis Research Advances
- Biopolymer Synthesis and Applications
- Medical Imaging and Pathology Studies
- Transgenic Plants and Applications
- Angiogenesis and VEGF in Cancer
- Immunodeficiency and Autoimmune Disorders
- Identification and Quantification in Food
- Carbohydrate Chemistry and Synthesis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Bacterial biofilms and quorum sensing
Centre d'Étude des Pathologies Respiratoires
2013-2024
Université de Tours
2003-2024
Inserm
2013-2024
Biologie des Oiseaux et Aviculture
2007-2014
Clinical Investigation Center Plurithematic Tours
2013-2014
Institut National de Recherche en Santé Publique
2014
Institut National de la Recherche Agronomique
2014
Physiologie de la Reproduction et des Comportements
2000-2004
Centre National de la Recherche Scientifique
2003
Pseudomonas aeruginosa is an opportunistic bacteria and a major cause of nosocomial pneumonia. P. has many virulence factors contributing to its ability colonize the host. LoxA lipoxygenase enzyme secreted byP. that oxidizes polyunsaturated fatty acids. Based on previous in vitro biochemical studies, several biological roles have been hypothesized, including interference host lipid signaling modulation bacterial invasion properties. However, contribution P.aeruginosa lung pathogenesis per se...
Abstract In dairy goats, treatments associating a progestogen and the equine chorionic gonadotropin (eCG) are easiest way to induce synchronize estrus ovulation permit artificial insemination (AI) and/or out of season breeding. From first treatment, injection eCG induces, in some females, production anti-eCG antibodies (Abs) that will interfere with effectiveness subsequent treatments. These Abs delay preovulatory LH surge time, leading poor fertility treated females. this study, by vitro...
K-ras mutations promote angiogenesis in lung cancer and contribute to the drug resistance of cells. It is not clear whether mutated adenocarcinomas are sensitive anti-angiogenic therapy with monoclonal antibodies (mAbs) that target vascular endothelial growth factor (VEGF). Anti-angiogenic mAbs usually delivered systemically, but only a small proportion reaches after intravenous injection. We investigated relevance non-invasive pulmonary route for delivery anti-VEGF mouse K-ras(LA1) model....
Out of the 14 avian β-defensins identified in Gallus gallus genome, only 3 are present chicken egg, including egg-specific β-defensin 11 ( Gga -AvBD11). Given its specific localization and established antibacterial activity, -AvBD11 appears to play a protective role embryonic development. is an atypical double-sized defensin, predicted possess 2 motifs related 6 disulfide bridges. The 3-dimensional NMR structure purified Gga- AvBD11 compact fold composed packed domains. This archetype...
Rationale: Neutrophil serine proteases in cystic fibrosis (CF) lung secretions partially resist inhibition by natural and exogenous inhibitors, mostly because DNA impairs their control. Cationic polypeptides display the property of condensing retain antimicrobial properties. We hypothesized that condensation cationic CF sputum would result a better control inflammation infection.Objectives: examined whether poly-l-lysine compact liquefy sputum, improve extracellular it displays antibacterial...
Pseudomonas aeruginosa is a major hospital-associated pathogen that can cause severe infections, most notably in patients with cystic fibrosis (CF) or those hospitalized intensive care units. Given its remarkable ability to resist antibiotics, P. eradication has grown more challenging. Therefore, there an urgent need discover and develop new strategies counteract aeruginosa-resistant strains. Here, we evaluated the efficacy of poly-L-lysine (pLK) combination commonly used antibiotics as...
The endotracheal tube (ETT) is an essential interface between the patient and ventilator in mechanically ventilated patients. However, a microbial biofilm formed gradually on this associated with development of ventilator-associated pneumonia. bacteria present are more resistant to antibiotics, current medical practices do not make it possible eliminate. Pseudomonas aeruginosa one leading pathogens that cause infections Poly-l-lysine (pLK) cationic polypeptide possessing antibacterial...
This study describes the synthesis and evaluation of different imprinted hydrogels using ribavirin as template molecule. Ribavirin serves a model molecule because it possesses broad-spectrum antiviral effect against RNA viruses, which are expected emerging viruses. The choice monomers enables to stabilize pre-polymerization complex synthesize biocompatible polymers. Predictive studies well experimental works conclude similar results on best ribavirin:monomers ratios. Thus, materials exhibit...
Bronchoscopy during mechanical ventilation of patients' lungs significantly affects because partial obstruction the tracheal tube, and may thus be omitted in most severely ill patients. It has not previously been possible to reduce external diameter bronchoscope without reducing suction channel, suctioning capacity device. We believed that a better-designed could improve safety bronchoscopy patients whose were ventilated. designed flexible prototype with drumstick-shaped head consisting...
<b>Introduction:</b> We recently showed that polycationic polymers such as poly-L-Lysines (pLK) were able to compact DNA, liquefy sputum of cystic fibrosis (CF) patients, inhibit bacterial growth <i>(Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus)</i>, favor the control neutrophil proteases by exogenous protease inhibitors (Dubois <i>et al.</i>, AJRCCM, 2013). Thus, pLK represent a promising alternative combination alpha-dornase antibiotics remains main therapeutics tentatively...
The increasing prevalence of multidrug-resistant