A5003612572- COVID-19 Clinical Research Studies
- Amoebic Infections and Treatments
- Inflammasome and immune disorders
- Long-Term Effects of COVID-19
- Parasitic Infections and Diagnostics
- SARS-CoV-2 and COVID-19 Research
- Parasites and Host Interactions
- COVID-19 and Mental Health
- SARS-CoV-2 detection and testing
- Viral gastroenteritis research and epidemiology
- Travel-related health issues
- Blood groups and transfusion
- Immune cells in cancer
- Escherichia coli research studies
- Hemoglobinopathies and Related Disorders
- COVID-19 Impact on Reproduction
- Olfactory and Sensory Function Studies
- Vaccine Coverage and Hesitancy
University of Helsinki
2019-2025
Helsinki University Hospital
2019-2025
Aava Medical Centre
2023
Abstract Background No licensed human vaccines are available against enterotoxigenic Escherichia coli (ETEC), a major diarrhoeal pathogen affecting children in low- and middle-income countries foreign travellers alike. ETVAX®, multivalent oral whole-cell vaccine containing four inactivated ETEC strains the heat-labile enterotoxin B subunit (LTB), has proved promising Phase 1 1/ 2 studies. Methods We conducted 2b double-blinded, randomized, placebo-controlled trial amongst Finnish to Benin,...
Convalescent plasma (CP) emerged as potential treatment for COVID-19 early in the pandemic. While efficacy hospitalised patients has been lacklustre, CP may be beneficial at first stages of disease. Despite multiple new variants emerging, no trials have involved analyses on variant-specific antibody titres CP.
The severity of COVID-19 is linked to excessive inflammation. Neutrophils represent a critical arm the innate immune response and are major mediators inflammation, but their role in pathophysiology remains poorly understood. We conducted transcriptomic profiling neutrophils obtained from patients with mild severe COVID-19, as well SARS-CoV-2 infected mice, comparison non-infected healthy controls. In addition, we investigated inflammasome formation potential mice upon infection....
Convalescent plasma (CP) therapy for COVID-19 infection may have favorable safety but varying efficacy, with concerns about its procoagulant impact. We investigated whether administration of CP to hospitalized patients affects their coagulation profile. Fifty-four randomized in a double-blinded fashion received either placebo, low-titer (LCP) or high-titer (HCP). Donor blood samples were obtained at the time plasmapheresis, while recipient collected before infusion, one day post-infusion and...
The intestinal parasite Dientamoeba fragilis (DF) is spread worldwide and can cause prolonged gastrointestinal symptoms, yet its link to international travel has been scarcely studied. To explore this connection, we examined the association between DF cases history by destination, comparing findings data on Giardia duodenalis (GD), a common travel-acquired parasite. We analysed clinical from patients with or GD infection in Helsinki Metropolitan Area, categorizing as travellers...
Background Despite the global distribution of intestinal protozoan Dientamoeba fragilis, its clinical picture remains unclear. This results from underdiagnosis: microscopic screening methods either lack sensitivity (wet preparation) or fail to reveal (formalin-fixed sample). Aim In a retrospective study setting, we characterised dientamoebiasis and compared it with giardiasis. addition, evaluated an improved approach formalin-fixed samples for suitability in diagnostics. Methods comprised...
Research into persistent symptoms among SARS-CoV-2-positive i.e. CoV(+) patients mostly focuses on hospitalized individuals. Our prospective follow-up study compares long COVID-associated laboratory-confirmed and SARS-CoV-2 negative [CoV(-)]
Dientamoeba fragilis (DF), the most common intestinal protozoal pathogen in affluent countries, causes asymptomatic or symptomatic infections with severity ranging from mild to disabling. Currently, many studies of treatment options only have small sample sizes and report results that are partly contradictory. Investigating data retrieved Helsinki University Hospital City patient records, we searched for effective antiprotozoal treating DF infections. To study microbiological clearance DF,...
Abstract The severity of COVID-19 is linked to excessive inflammation. Neutrophils represent a critical arm the innate immune response and are major mediators inflammation, but their role in pathophysiology remains poorly understood. We conducted transcriptomic profiling neutrophils obtained from patients with mild severe COVID-19, as well SARS-CoV-2 infected mice, comparison non-infected healthy controls. In addition, we investigated inflammasome formation potential mice upon infection....
Early in the COVID-19 pandemic, convalescent plasma (CP) emerged as a potentially effective treatment neutralising SARS-CoV-2. CP therapy with high antibody (NAb) titre may benefit outpatients and, sufficient quantities even some hospitalised patients. This study details process of setting up bank, containing high- and low-titre for clinical trial.
Background: The severity of COVID-19 is linked to excessive inflammation. Neutrophils represent a critical arm the innate immune response and are major mediators inflammation, but their role in pathophysiology remains poorly understood.Methods: We conducted transcriptomic profiling neutrophils obtained from patients with mild severe COVID-19, as well SARS-CoV-2 infected mice, comparison non-infected healthy controls. In addition, we investigated inflammasome formation potential mice upon...