A5079218277- T-cell and Retrovirus Studies
- RNA regulation and disease
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Gut microbiota and health
- Galectins and Cancer Biology
- Mycobacterium research and diagnosis
- Leprosy Research and Treatment
- Long-Term Effects of COVID-19
- Infectious Diseases and Tuberculosis
- Food Chemistry and Fat Analysis
- Natural Products and Biological Research
- Bamboo properties and applications
- Vector-Borne Animal Diseases
- Cocoa and Sweet Potato Agronomy
- Clostridium difficile and Clostridium perfringens research
- Respiratory viral infections research
- Science and Education Research
- Plant Taxonomy and Phylogenetics
- Tryptophan and brain disorders
- Immune Cell Function and Interaction
- Respiratory Support and Mechanisms
- Animal Disease Management and Epidemiology
Rega Institute for Medical Research
2020-2024
KU Leuven
2020-2024
Universidade Federal da Bahia
2016-2024
Complexo Hospitalar Universitário Professor Edgard Santos
2017
Understanding the pathology of COVID-19 is a global research priority. Early evidence suggests that respiratory microbiome may be playing role in disease progression, yet current studies report contradictory results. Here, we examine potential confounders by analyzing upper (n = 58) and lower 35) tract well-phenotyped patients controls combining sequencing, viral load determination, immunoprofiling. We find time intensive care unit type oxygen support, as well associated treatments such...
Abstract Background HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is an incapacitating neuroinflammatory disorder for which no disease-modifying therapy available, but corticosteroids provide some clinical benefit. Although HAM/TSP pathogenesis not fully elucidated, older age, female sex and higher proviral load are established risk factors. We investigated systemic cytokines a novel chronic inflammatory marker, GlycA, as possible biomarkers of immunopathogenesis...
Human T-Lymphotropic Virus type-1 (HTLV-1) is a unique retrovirus associated with both leukemogenesis and specific neuroinflammatory condition known as HTLV-1-Associated Myelopathy (HAM). Currently, most proposed HAM biomarkers require invasive CSF sampling, which not suitable for large cohorts or repeated prospective screening. To identify non-invasive incident in Brazilian cohort of PLwHTLV-1 (n=615 6,673 person-years clinical follow-up), we selected all plasma samples available at the...
Leprosy or hansen's disease is a spectral whose clinical forms mostly depends on host's immune and genetic factors. Different Toll-like receptors (TLR) variants have been described associated with leprosy, but some lack of replication across different populations.To evaluate the role polymorphisms in genes TLR1, TLR2 TLR4 susceptibility to leprosy case control study; verify association between genotypes these markers immunological profile serum patients leprosy.Pre-designed TaqMan® assays...
INTRODUCTION Human T-cell lymphotropic virus type 1 (HTLV-1)-associated inflammatory diseases are not well understood; however, their clinical manifestations may be influenced by the host genetic background. METHODS We genotyped 298 individuals with HTLV-1 and 380 controls for interleukin-10 (IL10) gene variants-rs3024496, rs1800871, rs1800896-and used logistic regression analysis to determine association phenotypes. RESULTS No infection was observed. However, allele A of rs1800896 (1082bp...
Abstract Understanding the pathology of COVID-19 is a global research priority. Early evidence suggests that respiratory microbiome may be playing role in disease progression, yet current studies report contradictory results. Here, we examine potential confounders by analyzing upper (n=58) and lower (n=35) tract well-phenotyped patients controls combining sequencing, viral load determination, immunoprofiling. We found time intensive care unit type oxygen support, both which are associated to...
Species delimitation in herbaceous bamboos has been complex and, some genera, a great part of its diversity confirmed only based on genetic information, as is the case genus Raddia. It includes nine species, all occurring Brazil, but R. portoi predominates dry forests Northeast associated with Caatinga phytogeographic domain. This species morphologically close to angustifolia, which known for single location Atlantic Forest Southern Bahia, and considered be threatened by extinction. Besides...
ABSTRACT Background HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is an incapacitating neuroinflammatory disorder for which no disease-modifying therapy available, but corticosteroids provide some clinical benefit. Objective To investigate systemic cytokines and GlycA as possible biomarkers of immunopathogenesis therapeutic response to corticosteroid pulse in HAM/TSP. Methods We prospectively followed 110 People living with HTLV-1 (PLwHTLV-1, 67 asymptomatic individuals...
Abstract Although the subject of intensive preclinical and clinical research, controversy on protective vs. deleterious effect interferon (IFN) in COVID-19 remains. Some apparently conflicting results are likely due to intricacy IFN subtypes (type I: IFN-alpha/beta, type III: IFN-lambda), timing mode administration (nebulized/subcutaneous) groups targeted (asymptomatic/mild, moderate, severe/critical COVID-19). Within COntAGIouS (COvid-19 Advanced Genetic Immunologic Sampling) trial, we...
Abstract Background: HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is an incapacitating neuroinflammatory disorder for which no disease-modifying therapy available, but corticosteroids provide some clinical benefit. Although HAM/TSP pathogenesis not fully elucidated, older age, female sex and higher proviral load are established risk factors. We investigated systemic cytokines a novel chronic inflammatory marker, GlycA, as possible biomarkers of immunopathogenesis...