A5049854053- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Ion channel regulation and function
- Vestibular and auditory disorders
- Neuroscience of respiration and sleep
- Hearing, Cochlea, Tinnitus, Genetics
- stochastic dynamics and bifurcation
- Genetic Neurodegenerative Diseases
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neural Engineering
- Neonatal and fetal brain pathology
- Plant and Biological Electrophysiology Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Cellular transport and secretion
- Pain Mechanisms and Treatments
- Spinal Cord Injury Research
- Signaling Pathways in Disease
- Mitochondrial Function and Pathology
- Functional Brain Connectivity Studies
- Fractal and DNA sequence analysis
- Nerve injury and regeneration
- Sleep and Wakefulness Research
Hertie Institute for Clinical Brain Research
2004-2020
University of Tübingen
2001-2020
Senckenberg Centre for Human Evolution and Palaeoenvironment
2012-2020
TH Bingen University of Applied Sciences
2010
University of Oslo
2004
New York University
1997-2001
Universidad de Montevideo
1994-1999
Universidad de la República de Uruguay
1990-1995
University of California, Los Angeles
1990
Malfunctions of potassium channels are increasingly implicated as causes neurological disorders. However, the functional roles large-conductance voltage- and Ca(2+)-activated K(+) channel (BK channel), a unique calcium, voltage-activated type have remained elusive. Here we report that mice lacking BK (BK(-/-)) show cerebellar dysfunction in form abnormal conditioned eye-blink reflex, locomotion pronounced deficiency motor coordination, which likely consequences learning deficiency. At...
Cortical-projecting thalamic neurons, in guinea pig brain slices, display high-frequency membrane potential oscillations (20–80 Hz), when their somata are depolarized beyond −45 mV. These oscillations, preferentially located at dendritic sites, supported by the activation of P/Q type calcium channels, as opposed to expected persistent sodium conductance responsible for such rhythmic behavior other central neurons. Short hyperpolarizing pulses reset phase and transiently increase amplitude...
Synaptic gain control and information storage in neural networks are mediated by alterations synaptic transmission, such as long-term potentiation (LTP). Here, we show using both vitro vivo recordings from the rat cerebellum that tetanization protocols for induction of LTP at parallel fiber (PF)-to-Purkinje cell synapses can also evoke increases intrinsic excitability. This form plasticity shares with a requirement activation protein phosphatases 1, 2A, 2B induction. Purkinje resembles CA1...
Although the entire output of cerebellar cortex is conveyed to deep nuclei neurons (DCNs) via GABAergic synapses established by Purkinje cells (PCs), very little known about strength and dynamic properties PC-DCN connections. Here we show that activation unitary connections induced large conductance changes (11.7 nS) in DCNs recorded whole cell patch configuration acute slices, suggesting activity single PCs might significantly affect its target neurons. Based on quantal content (18)...
New neurons generated in the adult dentate gyrus are constantly integrated into hippocampal circuitry and activated during encoding recall of new memories. Despite identification extracellular signals that regulate survival integration adult-born such as neurotrophins neurotransmitters, nature intracellular modulators required to transduce those remains elusive. Here, we provide evidence expression transcriptional activity nuclear factor T cell c4 (NFATc4) progenitor cells. We show NFATc4...
In the present report, we provide evidence that mesencephalic trigeminal (Mes-V) sensory neurons, a peculiar type of primary afferent cell with its body located within CNS, may operate in different functional modes depending on degree their membrane polarization. Using intracellular recording techniques slice preparation adult rat brain stem, demonstrate when these neurons are depolarized, they exhibit sustained, high-frequency, amplitude-modulated potential oscillations. Under conditions,...
Following hyperpolarizing inputs, many neurons respond with an increase in firing rate, a phenomenon known as rebound excitation. Rebound excitation has been proposed mechanism to encode and process inhibitory signals transfer them target structures. Activation of low-voltage-activated T-type calcium channels the ensuing low-threshold spikes is one mechanisms support However, there still not enough evidence that hyperpolarization provided by particularly those dependent on chloride ions,...
Abstract Low threshold voltage activated Kv1 potassium channels play key roles in regulating action potential (AP) threshold, neural excitability, and synaptic transmission. are highly expressed the cerebellum mutations of human genes associated to episodic forms ataxia (EAT-1). Besides well-established role controlling cerebellar basket-Purkinje cells synapses, by deep nuclear neurons (DCNs) where they regulate activity principal DCNs carrying output. include as well GABAergic serving...
In heterozygous Lurcher mice ( Lc/+), the Purkinje cells (PCs) degenerate almost totally during postnatal development. On other hand, their projection target, deep cerebellar nuclei (DCN), shows few signs of degeneration and seems to play an important role in maintaining a residual function Lc/+. We asked whether DCN Lc/+ develop cellular adaptations allowing them cope with loss GABAergic PC input. Using whole-cell patch-clamp recordings, we measured inhibitory postsynaptic currents from...
Modifications in the sensitivity of neural elements allow brain to adapt its functions varying demands. Frequency-dependent short-term synaptic depression (STD) provides a dynamic gain-control mechanism enabling adaptation different background conditions alongside enhanced input-driven changes activity. In contrast, synapses displaying frequency-invariant transmission can faithfully transfer ongoing presynaptic rates linear processing, deemed critical for many functions. However, rigid may...
ABSTRACT Modifications in the sensitivity of neural elements allow brain to adapt its functions varying demands. Frequency-dependent short-term synaptic depression (STD) provides a dynamic gain-control mechanism enabling adaptation different background conditions alongside enhanced input-driven changes activity. In contrast, synapses displaying frequency-invariant transmission can faithfully transfer ongoing presynaptic rates linear processing, deemed critical for many functions. However,...
ABSTRACT The Kv1 voltage-gated potassium channels (kv1.1-1.8) display characteristic low-threshold activation ranges what enables their role in regulating diverse aspects of neuronal function, such as the action potential (AP) threshold and waveform, thereby influence excitability or synaptic transmission. are highly expressed cerebellar cortex nuclei mutations human genes associated to episodic forms ataxia (EAT-1). Besides well-established basket-Purkinje cells inhibitory synapses cortex,...