A5026808572- Pituitary Gland Disorders and Treatments
- COVID-19 and healthcare impacts
- Diabetes and associated disorders
- Fatty Acid Research and Health
- Eicosanoids and Hypertension Pharmacology
- COVID-19 Clinical Research Studies
- Inflammatory mediators and NSAID effects
- Diabetes Management and Research
- Thyroid Disorders and Treatments
- Parathyroid Disorders and Treatments
- Pancreatic function and diabetes
- Health Systems, Economic Evaluations, Quality of Life
- Thyroid Cancer Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Diabetes Treatment and Management
- Lipoproteins and Cardiovascular Health
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Systemic Lupus Erythematosus Research
- Pharmaceutical industry and healthcare
- Inflammasome and immune disorders
- Adrenal Hormones and Disorders
- Diet and metabolism studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Bariatric Surgery and Outcomes
- Medication Adherence and Compliance
Virginia Commonwealth University
2025
Royal Berkshire NHS Foundation Trust
2013-2023
University of Oxford
2011-2023
Royal Berkshire Hospital
2010-2022
Weston Park Cancer Centre
2020-2022
Sheffield Teaching Hospitals NHS Foundation Trust
2022
Medical Research Council
2018
Harbor–UCLA Medical Center
2016
North Bristol NHS Trust
2014
Oxford Centre for Diabetes, Endocrinology and Metabolism
2010-2013
The use of aspirin for the secondary prevention cardiovascular disease (CVD) is firmly established, and proportional reductions in heart attacks strokes appear to be similar people with without diabetes. Uncertainty remains about role antiplatelet treatments primary CVD, guidelines vary their recommendations. It has also been hypothesized that long-term can prevent gastro-intestinal other cancers. Observational studies suggest associations between higher intakes omega-3 fatty acids (FA)...
Abstract Background Anaemia occurs early in the course of diabetes‐related chronic kidney disease (CKD). There is little evidence about prevalence anaemia people with diabetes. The aim this study was to assess anaemia, by stage CKD, general diabetic population. Methods Haemoglobin (Hb) measured on all glycated haemoglobin (HbA 1c ) samples and most recent (< 4 months) estimated glomerular filtration rate (eGFR) obtained. (at treatment level) defined as Hb < 110 g/l or use erythropoetic...
Hypogonadism in both sexes is a common result of ongoing treatment with opioid analgesics and can be treated suitable hormone replacement therapy
Clinical trials require cost-effective methods for identifying, randomising, and following large numbers of people in order to generate reliable evidence. ASCEND (A Study Cardiovascular Events iN Diabetes) is a randomised '2 × 2 factorial design' study aspirin omega-3 fatty acid supplements the primary prevention cardiovascular events with diabetes; this used central disease registers mail-based approach identify, randomise, follow 15,000 people. In collaboration UK consultants general...
The patient was a 26-year-old woman; she developed end stage renal disease (ESRD) due to IgA nephropathy. She on maintenance hemodialysis for one year. Her blood pressure 160/110 mmHg; barely controlled with 4 different anti-hypertensive drugs. It occasionally rose 220/130 mmHg at the of hemodialysis. Fundoscopy revealed Grade Hypertensive Retinopathy and carotid intima media thickness increased (1.0 mm). decreased 140/90 3 days after living donor kidney transplant, requiring monotherapy....
Dickkopf1(DKK1) is a quintessential Wnt antagonist and immunomodulator in various inflammatory diseases. The underlying molecular mechanisms of DKK1-mediated immunomodulation remain elusive. Here, we identified TLR4 as new receptor for DKK1 to activate NFκΒ pathway-mediated gene expressions pyroptosis via NLRP3 inflammasome human mouse macrophages. employed initiate NFκB signaling cascade MyD88. MyD88-TAK1-NFκΒ pathway activation by increased HIF1α, NFκB, protein expression levels, leading...
Abstract Dickkopf1 (DKK1) is a quintessential Wnt antagonist and has gained significant attention recently with its multifaceted role in modulating immune responses. Elevated levels of DKK1 multiple cancer types such as gastric, breast, head neck underscores significance potential biomarker therapeutic target for immunotherapy. However, the underlying molecular mechanisms DKK1’s inflammatory diseases remain unclear. Here, we demonstrated that acts an endogenous priming ligand NLRP3 (NOD-,...
Cancer patients are at increased risk of death from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). and its treatment affect many haematological biochemical parameters, therefore we analysed these prior to during disease 2019 (COVID-19) correlated them with outcome.
Kikuchi-Fujimoto Disease is a rare benign, condition of necrotising histiocytic lymphadenitis. A case 55 year old gentleman described here. He presented with fevers, weight loss and tender cervical lymph nodes. disease was diagnosed after node biopsy. Symptomatic treatment provided an uneventful full recovery made. Of significant note, this patient's daughter had almost decade earlier. Although has been reported widely, we believe the first familial report in literature occurring parent child.
Patients with cancer are at increased risk of severe COVID-19 disease, but have heterogeneous presentations and outcomes. Decision-making tools for hospital admission, severity prediction, monitoring early intervention critical. We sought to identify features disease in patients predicting build a decision support online tool, Risk Oncology Evaluation Tool (CORONET).
Metformin controls blood glucose, does not cause hypoglycaemia or weight gain and has been shown to reduce the long-term complications of diabetes, including macrovascular disease.1 Since metformin is renally cleared, there a genuine risk accumulation associated lactic acidosis in chronic kidney disease (CKD). We have previously argued that disproportionate fear surrounding safety CKD, with important side effects from alternative agents ignored. Both sulphonylureas insulin heart failure...
Abstract Context Autosomal dominant hypocalcemia types 1 and 2 (ADH1 ADH2) are caused by germline gain-of-function mutations of the calcium-sensing receptor (CaSR) its signaling partner, G-protein subunit α 11 (Gα 11), respectively. More than 70 different CaSR mutations, but only 6 Gα reported to date. Methods We ascertained additional ADH families investigated them for mutations. The effects identified variants on were evaluated transiently transfecting wild-type (WT) variant expression...
Large randomised trials have been successfully conducted using mailed drug supply and follow-up [1-4] . ASCEND (A Study of Cardiovascular Events iN Diabetes) is a “2x2 factorial design” study aspirin versus placebo omega-3 fatty acid placebo, for the primary prevention cardiovascular events in people with diabetes. In order to be able 15,000 diabetes about 7 years at low cost, streamlined run mainly by mail back-up from 24-hour Freefone service.
Continuous glucose monitoring (CGM) for diabetes combines noninvasive biosensors, continuous monitoring, cloud computing, and analytics to connect simulate a hospital setting in person's home. CGM systems inspired methods measure glycemic variability (GV), but existing GV disregard trends patterns; hence, they fail capture entire temporal patterns do not provide granular insights about fluctuations.
Abstract Background Aspirin is widely used for cardioprotection with its antiplatelet effects due to the blocking of thromboxane A2 production. However, it has been suggested that platelet abnormalities in those diabetes prevent adequate suppression once daily aspirin. Methods In ASCEND randomized double-blind trial aspirin 100 mg versus placebo participants but no history cardiovascular disease, was assessed by measuring 11-dehydro-thromboxane B2 excretion urine (U-TXM) a randomly selected...
<h3>Background</h3> Fatigue is highly prevalent and has a negative impact on quality of life in patients with Systemic Lupus Erythematosus.<sup>1,2</sup> The 9-item Severity Scale (FSS) one the commonly used self-report questionnaires to measure fatigue chronic disease.<sup>3</sup> Although most reported symptoms SLE, previous studies have not consistently found any clear association between disease activity (as measured by SLEDAI)<sup>4</sup> or laboratory measures activity.<sup>1</sup>...
Abstract Background Cancer patients are at increased risk of severe COVID-19. As COVID-19 presentation and outcomes heterogeneous in cancer patients, decision-making tools for hospital admission, severity prediction monitoring early intervention critical. Objective To identify features predicting disease build a decision-support online tool; Risk Oncology Evaluation Tool (CORONET) Method Data was obtained consecutive with active laboratory confirmed presenting 12 hospitals throughout the...