A5040242480- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- Peptidase Inhibition and Analysis
- Bioactive natural compounds
- Chronic Lymphocytic Leukemia Research
- Surface Chemistry and Catalysis
- Cancer therapeutics and mechanisms
- Oxidative Organic Chemistry Reactions
- Cancer Treatment and Pharmacology
- Ubiquitin and proteasome pathways
- Asymmetric Hydrogenation and Catalysis
- Asymmetric Synthesis and Catalysis
- Eating Disorders and Behaviors
- Silymarin and Mushroom Poisoning
- Cancer-related cognitive impairment studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Organometallic Complex Synthesis and Catalysis
- Advanced Breast Cancer Therapies
- Systemic Sclerosis and Related Diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Protein Degradation and Inhibitors
- Consumer Attitudes and Food Labeling
- Heat shock proteins research
Eli Lilly (Ireland)
2019-2024
Target (United States)
2023
University of South Florida
2018-2021
Sutter Medical Center
2009-2018
United States Air Force
2018
University College Dublin
2012-2015
University of Arizona
2005-2008
Arizona Oncology
2005-2007
UPMC Hillman Cancer Center
2004-2005
University of Pittsburgh
2004
Excess aldosterone production contributes to hypertension in both classical hyperaldosteronism and obesity-associated hypertension. Therapies that reduce synthesis may lower blood pressure.
We studied five patients with clinically manifest hemochromatosis and 19 of their siblings children to define better the diagnostic criteria for stages disease. The earliest detectable abnormalities were an increase in hepatic-parenchymal-cell stainable iron, hepatic iron concentration, transferrin saturation serum concentration. In contrast, urinary excretion after deferoxamine ferritin concentration usually normal early loading. either latent or disease, Iron was Grade 3 4; >250 μg per 100...
Summary This open‐label, dose escalation, multicentre phase 1/2 trial was undertaken to determine the safety and tolerability of heat shock protein 90 (HSP90) inhibitor tanespimycin (100–340 mg/m 2 ) + bortezomib (0·7–1·3 given on days 1, 4, 8 11 in each 21‐d cycle. Phase expansion occurred at highest tested 340 1·3 . Seventy‐two patients (median age, 60 years) with relapsed or refractory multiple myeloma (MM) were enrolled; 63 (89%) completed study. Tanespimycin combination well tolerated;...
The aim of this exploratory study was to assess the safety and clinical effects autologous umbilical cord blood (AUCB) infusion in children with idiopathic autism spectrum disorder (ASD). Twenty-nine 2 6 years age a confirmed diagnosis ASD participated randomized, blinded, placebo-controlled, crossover trial. Participants were randomized receive AUCB or placebo, evaluated at baseline, 12, 24 weeks, received opposite infusion, then re-evaluated same time points. Evaluations included...
A method for the catalytic asymmetric α-arylation of ketones bearing very sterically hindered aryl rings has been developed. This reaction occurs under mild conditions, in short times and applied to first synthesis isoflavanones.
Abstract A modular six‐step asymmetric synthesis of two naturally occurring and three non‐natural isoflavanones containing tertiary α‐aryl carbonyls is reported. This synthetic route, utilising a Pd‐catalyzed decarboxylative protonation, produces in excellent enantioselectivities from 76–97 %. switch the sense stereoinduction was observed when different H + sources were employed, showing first example dual stereocontrol an protonation reaction. The enantioselective sativanone 3‐ o...
// Paulina Ćwiek 1 , Zaira Leni Fabiana Salm Valeriya Dimitrova Beata Styp-Rekowska 2 Gianpaolo Chiriano 3 Michael Carroll 4 Katrin Höland Valentin Djonov Leonardo Scapozza Patrick Guiry and Alexandre Arcaro Division of Pediatric Hematology/Oncology, Bern University Hospital, Bern, Switzerland Institute Anatomy, Pharmaceutical Biochemistry, School Sciences, Geneva, Lausanne, Centre for Synthesis Chemical Biology, College Dublin, Belfield, Ireland Correspondence: Arcaro, email: Keywords :...
PURPOSE: A variety of adjuvant treatments and cytoprotective agents have been proposed to lessen the toxicity radiation therapy. The following study was designed evaluate benefit six or combinations using anastomotic bursting strength as a measure transmural injury. METHODS: 40-Gy consisted following. Seventy-two male Sprague-Dawley rats were divided into eight equal groups: nonradiated control, radiated untreated treated groups. radioprotective included ribose-cysteine (RibCys), WR-2721,...
All X-ray structures of PN ligands forming 6-ring metal complex chelates have been retrieved from the CDS database, and those lacking chelate chirality filtered out. Many remainder fit naturally into four main families (PPFA, FcPhox, Phox Quinap), which widely applied to asymmetric catalysis in diverse ways. It is known through experimental observation that certain these ligand are more effective for specific classes reaction but there has little by way explanation their divergent behaviour....
We present a case with extremely late diagnosis of type II hereditary angioedema (HAE). Given recent advances in HAE treatment, we want to bring physician awareness this condition and aid earlier detection. is disorder associated episodes the face, larynx, lips, abdomen, or extremities. Late can lead significant morbidity severely impairing due recurring attacks. The ordinarily made during childhood adolescence. Delayed diagnoses early middle adulthood have been documented literature....
Abstract The prognosis for patients with nonseminomatous germ cell tumor of the testis is good, even when extensive metastatic disease present, because this very sensitive to chemotherapy cisplatin, vinblastine, and bleomycin (PVB). If a metastasis occurs in brain, however, poor blood-brain barrier limits entrance these drugs into brain creates sanctuary tumor. current treatment either standard PVB plus whole radiation therapy or rigorous chemotheraputic regimen that penetrates better than...
It is hypothesized that parents of children with allergic conditions believe dairy products are potentially harmful to their child.This study compares the calcium and vitamin D intake versus non-allergic parental beliefs about milk products.A survey food-frequency-questionnaire were administered between 3 13 years, 110 disease (allergic rhinitis, asthma, food allergy, and/or atopic dermatitis) without disease. Calcium was calculated from compared National Institutes Health recommendations....
A new synthesis for an intermediate of abemaciclib is described. Keys to this route are the use inexpensive starting materials, biphasic amine alkylation mild C–N bond formation, anhydrous coupling a 2-chloropyridine derivative with LiHMDS avoid hydroxy impurity, and neutral, fluoride-free conditions affect desilylation. Scale-up optimized described on kilogram scale.
Improved reaction conditions have been developed for a telescoped Miyaura borylation/Suzuki coupling process, which is utilized in the synthesis of an abemaciclib intermediate. Key improvements include situ generation lipophilic base and tailored ligand selection each palladium-catalyzed step. Optimizing choice significantly reduced aryl scrambling, major source impurities borylation Additionally, process led to shortened times lower palladium loadings, resulting more efficient,...