A5085524593- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Hormonal Regulation and Hypertension
- Hemodynamic Monitoring and Therapy
- Cardiac Health and Mental Health
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Lipoproteins and Cardiovascular Health
- Cardiovascular Health and Disease Prevention
- Cardiovascular and exercise physiology
- Cardiac Imaging and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Cancer, Lipids, and Metabolism
- Cardiovascular Syncope and Autonomic Disorders
- Sarcoidosis and Beryllium Toxicity Research
- Sodium Intake and Health
- Artificial Intelligence in Healthcare and Education
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Aortic Disease and Treatment Approaches
- Mechanical Circulatory Support Devices
- Pharmaceutical Economics and Policy
- Machine Learning in Healthcare
- Advanced MRI Techniques and Applications
- Stroke Rehabilitation and Recovery
- Pericarditis and Cardiac Tamponade
Cleveland Clinic
2018-2025
Center for Clinical Research (United States)
2023-2025
Cleveland Clinic Lerner College of Medicine
2024
Case Western Reserve University
2023-2024
Orthopedic Institute
2024
Radiance Technologies (United States)
2023
Target (United States)
2023
Miller Orthopedic Specialist
2022
University of Chicago Medical Center
2016-2018
University of Chicago
2014-2018
This study examines the appropriateness of artificial intelligence model responses to fundamental cardiovascular disease prevention questions.
Background— Cardiac sarcoidosis is associated with an increased risk of heart failure and sudden death, but its in patients preserved left ventricular ejection fraction unknown. Using cardiovascular magnetic resonance extracardiac fraction, we sought to (1) determine the prevalence cardiac or myocardial damage, defined by presence late gadolinium enhancement (LGE), (2) quantify their death/ventricular tachycardia (VT), (3) identify imaging-based covariates that predict who at greatest...
Excess aldosterone production contributes to hypertension in both classical hyperaldosteronism and obesity-associated hypertension. Therapies that reduce synthesis may lower blood pressure.
The effects of bempedoic acid on cardiovascular outcomes in statin-intolerant patients without a prior event (primary prevention) have not been fully described.To determine the primary prevention patients.This masked, randomized clinical trial enrolled 13 970 (enrollment December 2016 to August 2019 at 1250 centers 32 countries), including 4206 patients.Participants were oral acid, 180 mg daily (n = 2100), or matching placebo 2106).The efficacy measure was time from randomization first...
Supplements are commonly used by individuals with indications for lipid-lowering therapy, but evidence of their effectiveness to lower low-density lipoprotein cholesterol (LDL-C) is lacking, particularly when compared statins. The trial objective was compare the efficacy a low-dose statin placebo and 6 common supplements in impacting lipid inflammatory biomarkers. This single-center, prospective, randomized, single-blind clinical among adults no history atherosclerotic cardiovascular disease...
Abstract Introduction : Many of the deleterious effects associated with chronic kidney disease (CKD) are secondary to resultant systemic inflammation. The gut microbial changes caused by CKD thought perpetuate Therefore, strategies aimed at modulating microbiota may be helpful in reducing complications CKD. We hypothesized that supplementation high‐amylose maize resistant starch type 2 (HAM‐RS2) would beneficially alter microbiome and lead lower levels Methods A double‐blind, parallel,...
Background Cardiac infiltration is an important cause of death in sarcoidosis. Transthoracic echocardiography ( TTE ) has limited sensitivity for the detection cardiac sarcoidosis CS ). Late gadolinium enhancement LGE cardiovascular magnetic resonance CMR used to diagnose but limitations cost and availability. We sought determine whether ‐derived global longitudinal strain GLS may be identify individuals with , despite preserved left ventricular ejection fraction LVEF ), abnormal associated...
Although statins reduce adverse cardiovascular outcomes, less than half of eligible patients receive treatment. A nonprescription statin has the potential to improve access statins. To assess concordance between clinician and consumer assessment eligibility for treatment using a Technology Assisted Self-Selection (TASS) Web Application (Web App) evaluate effect on low-density lipoprotein cholesterol (LDL-C) levels. prospective actual use 6-month study App qualify participants without medical...
Background Although left ventricular (LV) ejection fraction (EF) and global longitudinal strain (GLS) are recommended by the current echocardiographic chamber quantification guidelines, these measurements not performed routinely. Because EF rely on manual tracing of LV boundaries, subject to inter‐reader variability experience dependence, we hypothesized that semiautomated GLS using speckle tracking would be more reproducible less experience‐dependent. Methods Images from 30 patients were...
Hypertension is a widely prevalent disease and uncontrolled hypertension predisposes affected individuals to severe adverse effects. Though the importance of controlling clear, multitude therapeutic regimens patient factors that affect success blood pressure control makes it difficult predict likelihood whether patient’s will be controlled. This project endeavors investigate machine learning can accurately within 12 months clinical encounter. To build model, retrospective review electronic...
The left ventricle ( LV ) is affected in 20–25% of patients with sarcoidosis and its involvement associated morbidity mortality. However, effects on the right RV are not well documented. Our aims were to investigate prevalence dysfunction determine whether it predominantly direct cardiac involvement, severity lung disease, or pulmonary hypertension PH ). We identified 50 biopsy‐proven extra‐cardiac preserved function, who underwent echocardiography, function PF testing, cardiovascular...
Aldosterone dysregulation contributes to hypertension. Lorundrostat is an aldosterone synthase inhibitor, but data on its efficacy and safety in patients with hypertension are limited. In this multicenter, double-blind, randomized, placebo-controlled trial, we assigned participants who were receiving two five antihypertensive medications had a blood-pressure measurement of 140/90 mm Hg or higher obtained during office visit undergo standardized regimen for 3 weeks. Subsequently, average...