A5090967679- Schizophrenia research and treatment
- Psychosomatic Disorders and Their Treatments
- Bipolar Disorder and Treatment
- Mental Health and Psychiatry
- Mental Health Treatment and Access
- Epilepsy research and treatment
- Advanced Neuroimaging Techniques and Applications
- Personality Disorders and Psychopathology
- Neurobiology of Language and Bilingualism
- Neurological disorders and treatments
- Child and Adolescent Psychosocial and Emotional Development
- Genetic Syndromes and Imprinting
- Hemispheric Asymmetry in Neuroscience
- Adolescent and Pediatric Healthcare
- Autism Spectrum Disorder Research
- Genetic Associations and Epidemiology
- Mental Health Research Topics
- Genetics and Neurodevelopmental Disorders
- Fetal and Pediatric Neurological Disorders
- Family Caregiving in Mental Illness
- Psychotherapy Techniques and Applications
- Treatment of Major Depression
- Prenatal Screening and Diagnostics
- Psychology of Development and Education
- Islamic Finance and Communication
King's College London
2009-2025
Central and North West London NHS Foundation Trust
2017-2025
South London and Maudsley NHS Foundation Trust
2009-2016
Centre for Mental Health
2016
Camden and Islington NHS Foundation Trust
2016
Royal Holloway University of London
2014
Studies of the major psychoses, schizophrenia (SZ) and bipolar disorder (BD), have traditionally focused on genetic environmental risk factors, although more recent work has highlighted an additional role for epigenetic processes in mediating susceptibility. Since monozygotic (MZ) twins share a common DNA sequence, their study represents ideal design investigating contribution factors to disease etiology. We performed genome-wide analysis methylation peripheral blood samples obtained from...
Acquisition of language skills depends on the progressive maturation specialized brain networks that are usually lateralized in adult population. However, how genetic and environmental factors relate to age-related differences lateralization these pathways is still not known. We recruited 101 healthy right-handed subjects aged 9–40 years investigate anatomy perisylvian 86 twins (52 monozygotic 34 dizygotic) understand heritability influence anatomy. Diffusion tractography was used dissect...
Individual differences in cognitive ability and social behaviour are influenced by the variability structure function of limbic system. A strong heritability cortex has been previously reported, but little is known about how genetic factors influence specific networks. We used diffusion tensor imaging tractography to investigate different tracts 52 monozygotic 34 dizygotic healthy adult twins. explored connections that contribute activity three distinct functional networks, namely dorsal...
Abstract Background Psychiatric research is increasingly embracing a paradigm shift from categorical diagnoses to neurobiologically meaningful dimensions that cross current diagnostic boundaries. This transposition calls for redefining endophenotypes accommodate transdiagnostic vulnerabilities. We sought identify shared and disorder-specific neurocognitive schizophrenia, bipolar I disorder (BD-I) broad psychosis/BD-I phenotype in mega-analysis of twin/sibling data. Study Design performed...
We analysed Stroop (neuropsychological screening test) measures of response inhibition in 18 twin pairs discordant for bipolar I disorder compared with 17 healthy control pairs, as well 40 singletons psychotic features and a family history psychosis, 46 their first-degree relatives without or psychosis 48 controls. In both studies, individuals showed deficits intact performance. the patients, an interference score was associated depressive symptoms. Having relative disorder, even familial,...
Aims At first‐episode psychosis ( FEP ), many patients will be routed within familial networks and supported by informal carers who are predominately close family members such as parents. Carer burden, distress poorer coping styles associated with different illness beliefs. The current study sought to examine the impact acceptability of a 3 session, cognitively informed, group intervention targeting beliefs previously linked caregiving experiences in carers. Methods Carers attending routine...
Twin studies have lacked statistical power to apply advanced genetic modelling techniques the search for cognitive endophenotypes bipolar disorder.To quantify shared variability between disorder and measures.Structural equation was performed on data collected from 331 twins/siblings of varying relatedness, disease status concordance disorder.Using a parsimonious AE model, verbal episodic spatial working memory showed statistically significant correlations with (rg = |0.23|-|0.27|), which...
The genes for the dopamine transporter (DAT) and D-Amino acid oxidase activator (DAOA or G72) have been independently implicated in risk schizophrenia bipolar disorder and/or their related intermediate phenotypes.DAT G72 respectively modulate central glutamate transmission, two systems most robustly these disorders.Contemporary studies demonstrated that elevated function is associated with glutamatergic dysfunction psychotic disorders.Using functional magnetic resonance imaging we examined...
Aim: To investigate relationships between stress, resilience, recovery style, and persecutory delusions in early psychosis.Methods: Thirty-nine participants completed questionnaires a cross-sectional design.Results: Higher lower sealing-over style predicted higher delusional severity accounted for 31% of the variance delusion severity.Conclusions: Enhancing stress-coping strategies, building facilitating an integrative may be helpful intervention targets reducing patients with psychosis.
Abstract Cognitive behaviour therapy (CBT) is now the psychological treatment of choice for psychosis but meta-analyses indicate a low effect size on delusions, so further innovations are clearly needed, and group CBT (GCBTp) an under-researched area. This study aimed to service-evaluate feasibility, satisfaction, safety, effectiveness specifically targeting medication-resistant single delusions in early patients (EI-GCBTp). Three separate EI-GCBTp groups were run resulting total 11...