- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Virus-based gene therapy research
- Intraocular Surgery and Lenses
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Xenotransplantation and immune response
- Retinopathy of Prematurity Studies
- Renal Transplantation Outcomes and Treatments
- Retinal Development and Disorders
- Ocular Disorders and Treatments
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Retinal Imaging and Analysis
- Viral Infectious Diseases and Gene Expression in Insects
- T-cell and B-cell Immunology
- Silicon Nanostructures and Photoluminescence
- Immunotherapy and Immune Responses
- Neonatal Respiratory Health Research
- interferon and immune responses
Flinders University
2014-2024
Flinders Medical Centre
2007-2023
Adelaide Institute for Sleep Health
2021-2023
South Australian Health and Medical Research Institute
2017
University of South Australia
1985-2007
Mount Medical Centre
2007
Oregon Health & Science University
2000
Children’s Health Research Institute
1999
The University of Adelaide
1999
Australian Red Cross Lifeblood
1992
Background. Our aims were to examine graft survival and visual outcome after full-thickness corneal transplantation. Methods. Records of 18,686 penetrating grafts, 14,622 with archival follow-up from 1 22 years, examined within a national database. Kaplan-Meier analysis indicated variables interest for Cox proportional hazards regression analysis. A model clustered by patient control intereye or intergraft dependence was constructed identify best predicting failure. Visual acuity in the...
Background. In a large patient cohort, we investigated long-term corneal graft outcome, risk factors for failure, and whether survival had improved over time. Methods. Records of 10,952 full-thickness grafts with associated archival follow-up were examined within prospectively-maintained, national database 13,831 records, extending up to 18 years. Kaplan-Meier analysis was used indicate variables interest Cox proportional hazards regression analysis. A model clustered by individual control...
A quantitative estimation of the amounts human Ia (HLA-DR) and HLA-ABC antigen on a variety tissues was performed. Monoclonal antibodies to species-common determinants HLA-DR antigens were absorbed quantitatively with tissue homogenates cell suspensions, reassayed for residual activity in radioimmunobinding assay. Kidney found carry 90% as much 14% spleen, while liver contained 19 9% much, respectively. Small both heart; brain carried very little virtually no DR. Neither nor DR erythrocytes...
Monoclonal antibodies to human monomorphic class I and II major histocompatibility complex (MHC) determinants have been used with immunofluorescence immunoperoxidase techniques, localize these antigens in normal kidneys. HLA-DR antigen was located the glomeruli (probably on endothelium as well mesangium) within cells of cortical medullary tubules. Dendritic renal inter-stitium stained brightly for DR could be distinguished from staining capillary endothelium. The vascular large vessels less...
Background. Modification of a donor cornea by gene therapy ex vivo has potential to modulate irreversible rejection, the major cause corneal graft failure. Our aim was transfer encoding mammalian IL-10 ovine corneas and determine subsequent orthotopic allograft survival in an outbred sheep model. Methods. The replicative capacity endothelium determined autoradiography after deliberate injury. A replication-defective adenovirus used deliver lacZ reporter transfected were organ-cultured vitro...
The immunosuppressive effects of cyclosporin A were tested in a DA (RT-1a) to Lewis (RT-1(1) rat renal allograft model, which represents very strong histocompatibility barrier. Dose-response studies established that oral doses 5 mg/kg/day or higher gave complete suppression rejection, while 2 lower without effect. Intravenous administration the drug approximately doubled its potency. Time showed period was also critical, with 7- 14-day treatment course orally giving prolonged graft survival,...
Porous silicon (pSi) and poly(L-lactide) (PLLA) both display good biocompatibility tunable degradation behavior, suggesting that composites of materials are suitable candidates as biomaterials for localized drug delivery into the human body. The combination a pliable soft polymeric material with hard inorganic porous high loading capacity may engender improved control over release profiles be beneficial preparation advanced devices biodegradable implants or scaffolds.In this work, three...
Success of Ebola virus (EBOV) as a human pathogen relates at the molecular level primarily to blockade host cell type I interferon (IFN) antiviral response. Most individuals who survive disease (EVD) develop chronic syndrome: approximately one-quarter survivors suffer from uveitis, which has been associated with presence EBOV within eye. Clinical observations post-Ebola uveitis indicate involvement retinal pigment epithelial cells.We inoculated ARPE-19 cells EBOV, and followed course...