A5058314453- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Esophageal and GI Pathology
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- RNA modifications and cancer
- Colorectal and Anal Carcinomas
- Semiconductor materials and devices
- Metal and Thin Film Mechanics
- Industrial Technology and Control Systems
- Iterative Learning Control Systems
- Advanced Numerical Analysis Techniques
- Circular RNAs in diseases
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Advanced machining processes and optimization
- Inflammatory Biomarkers in Disease Prognosis
- Bladder and Urothelial Cancer Treatments
- Advancements in Semiconductor Devices and Circuit Design
- Tracheal and airway disorders
Guilin University of Electronic Technology
2024-2025
Sun Yat-sen University Cancer Center
2019-2025
Sun Yat-sen University
2019-2025
Xinjiang Normal University
2025
State Key Laboratory of Oncology in South China
2021-2024
Hefei University of Technology
2022-2023
Cancer Institute (WIA)
2023
Shenzhen Pingle Orthopedic Hospital
2023
University of Colorado Denver
2023
University of Colorado Cancer Center
2023
Neoplastic cells use various intercellular communication mechanisms in order to adapt the local microenvironment, manipulate immune system, and facilitate metastasis. Exosomes release is a new mechanism of cell-to-cell communication. These nanovesicles enclose types molecules including lipids, proteins, DNA, messenger RNA (mRNA) non-coding RNAs [microRNA long (lncRNA)]. lncRNAs are over 200 nt transcripts, that exhibit no coding potential, but crucial regulators physiological processes...
The cancer-risk-associated rs6983267 single nucleotide polymorphism (SNP) and the accompanying long noncoding RNA CCAT2 in highly amplified 8q24.21 region have been implicated cancer predisposition, although causality has not established. Here, using allele-specific transgenic mice, we demonstrate that overexpression leads to spontaneous myeloid malignancies. We further identified is overexpressed bone marrow peripheral blood of myelodysplastic/myeloproliferative neoplasms (MDS/MPN)...
To evaluate the efficacy and safety of toripalimab combined with neoadjuvant chemoradiotherapy (NCRT) for locally advanced esophageal squamous cell carcinoma (ESCC).In this single arm, phase II trial, 44 ESCC patients were enrolled from December 2019 to July 2021 at Sun Yat-sen University Cancer Center (Guangzhou, China). All received concurrent radiotherapy (44 Gy in 20 fractions), chemotherapy (paclitaxel 50 mg/m2 cisplatin 25 on days 1, 8, 15, 22), (240 mg 1 22). Within 6-8 weeks...
PURPOSE To assess the efficacy and safety of radiofrequency ablation (RFA) versus stereotactic body radiotherapy (SBRT) in treating recurrent small hepatocellular carcinoma (HCC). METHODS In this trial, patients with HCC (single lesion ≤5 cm) were randomly assigned to receive either SBRT or RFA. The primary end point was local progression-free survival (LPFS), secondary points (PFS), overall (OS), control rate, safety. RESULTS Between August 2019 April 2022, 166 (n = 83) RFA groups. After a...
Abstract The combination of toripalimab (an anti-PD-1 antibody) with definitive chemoradiotherapy (CRT) demonstrated encouraging efficacy against locally advanced esophageal squamous cell carcinoma (ESCC) in the EC-CRT-001 phase II trial (NCT04005170). primary endpoint this was clinical complete response rate (cCR), and secondary endpoints included overall survival (OS), progression-free (PFS), duration response, quality life. exploratory analyses include exploring role circulating tumor DNA...
The introduction of immune-checkpoint blockade in the cancer therapy led to a paradigm change management late stage cancers. There are already multiple FDA approved checkpoint inhibitors and many other agents undergoing phase 2 early 3 clinical trials. therapeutic indication immune expanded last years, but still remains unclear who can benefit. MicroRNAs small RNAs with no coding potential. By complementary pairing 39 untranslated region messenger RNA, microRNAs exert posttranscriptional...
Despite definitive chemoradiotherapy (CRT) being a recommended therapeutic method for patients with T4b esophageal squamous cell carcinoma (ESCC), treatment response and complications remain unclear. Esophageal fistula is severe CRT-related complication when treating locally advanced ESCC, but data on risk factors that lead to formation are limited. The aim of this analysis characterize the outcomes ESCC treated by CRT investigate fistula.We retrospectively analyzed 136 clinically...
Abstract Background To investigate the association between absolute lymphocyte count (ALC) nadir and survival outcomes in esophageal squamous cell carcinoma (ESCC) patients who received definitive chemoradiotherapy (CRT) combined with anti-PD-1 immunotherapy, as well to explore clinical characteristics dosimetric parameters that affect ALC during CRT. Patients Methods ESCC (n = 602) underwent CRT were analyzed, of whom 166 immunotherapy Changes compared without immunotherapy. Propensity...
This phase I study aimed to assess the safety, dose-limiting toxicity (DLT), maximum tolerated dose (MTD) and preliminary effect of nanoparticle albumin-bound (nab)-paclitaxel in combination with concurrent chemoradiotherapy patients locally advanced esophageal squamous cell carcinoma (ESCC).Patients ESCC who were ineligible or refused surgery enrolled. Nab-paclitaxel (60 mg/m2 , 75 90 ) cisplatin (25 administered intravenously weekly on days 1, 8, 15, 22, 29 basis 3 + escalation method. The...
This paper investigates the energy transfer and data collection problem of multiple unmanned aerial vehicle (UAV)-assisted wireless-powered Internet Things (IoT) networks. To ensure information freshness for IoT devices reduce UAVs’ consumption, we minimize average Age Information (AoI) by jointly optimizing harvesting (EH) time devices, selection points (DCPs), DCP-IoT associations, task assignment, flight speed, trajectories UAVs, subject to limited endurance UAVs. As this is nonconvex,...