A5079492888- HIV/AIDS drug development and treatment
- Biochemical and Molecular Research
- Synthesis and Characterization of Heterocyclic Compounds
- Pneumocystis jirovecii pneumonia detection and treatment
- Organophosphorus compounds synthesis
- Tuberculosis Research and Epidemiology
- Click Chemistry and Applications
- Cancer therapeutics and mechanisms
- Herpesvirus Infections and Treatments
- HIV Research and Treatment
- Cytomegalovirus and herpesvirus research
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Mycobacterium research and diagnosis
- Microbial Natural Products and Biosynthesis
- DNA and Nucleic Acid Chemistry
- Polyamine Metabolism and Applications
- Synthesis and Biological Evaluation
- Hepatitis C virus research
- Synthesis and biological activity
- Cannabis and Cannabinoid Research
- Pancreatic function and diabetes
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Reactivity of Heterocycles
- T-cell and Retrovirus Studies
Engelhardt Institute of Molecular Biology
2013-2024
Russian Academy of Sciences
2008-2014
Ural Branch of the Russian Academy of Sciences
2010
Institute of Organic Synthesis
2010
State Research Center of Virology and Biotechnology VECTOR
2001
Hepatitis C virus (HCV) infection is accompanied by the induction of oxidative stress, mediated several proteins, most prominent being nucleocapsid protein (HCV core). Here, using truncated forms HCV core, we have delineated mechanisms which it induces stress. The N-terminal 36 amino acids core induced TGFβ1-dependent expression nicotinamide adenine dinucleotide phosphate (NADPH) oxidases 1 and 4, both independently contributed to production reactive oxygen species (ROS). same fragment also...
ABSTRACT Influenza viruses of types A and B cause periodic pandemics in the human population. The antiviral drugs approved to combat influenza virus infections are currently limited. We have investigated an effective novel inhibitor viruses, triazavirine {2-methylthio-6-nitro-1,2,4-triazolo[5,1-c]-1,2,4-triazine-7(4Í)-one} (TZV). TZV suppressed replication cell culture chicken chorioallantoic membranes, it protected mice from death caused by type viruses. was also against a...
Changes in metabolic pathways are often associated with the development of various pathologies including cancer, inflammatory diseases, obesity and syndrome. Identification particular events that dysregulated may yield strategies for pharmacologic intervention. However, such studies hampered by use classic cell media do not reflect metabolite composition exists blood plasma which cause non-physiological adaptations cultured cells. In recent years two groups presented aim to human plasma,...
Three series of 5-arylaminouracil derivatives, including 5-(phenylamino)uracils, 1-(4'-hydroxy-2'-cyclopenten-1'-yl)-5-(phenylamino)uracils, and 1,3-di-(4'-hydroxy-2'-cyclopenten-1'-yl)-5-(phenylamino)uracils, were synthesized screened for potential antimicrobial activity. Most compounds had a negative effect on the growth Mycobacterium tuberculosis H37Rv strain, with 100% inhibition observed at concentrations between 5 40 μg/mL. Of those,...
The rapid increase in the antibiotic resistance of microorganisms, capable causing diseases humans as destroying cultural heritage sites, is a great challenge for modern science. In this regard, it necessary to develop fundamentally novel and highly active compounds. study, series N4-alkylcytidines, including 5- 6-methylcytidine derivatives, with extended alkyl substituents, were obtained order new generation antibacterial antifungal biocides based on nucleoside derivatives. It has been...
Hepatitis C virus (HCV) is an oncogenic that causes chronic liver disease in more than 80% of patients. During the last decade, efficient direct acting antivirals were introduced into clinical practice. However, clearance does not reduce risk end-stage diseases to level observed patients have never been infected. So, investigation HCV pathogenesis still warranted. Virus-induced changes cell metabolism contribute development HCV-associated pathologies. Here we studied impact on polyamines and...
Hepatitis C virus (HCV) is an oncogenic that causes chronic liver disease in more than 80% of patients. During the last decade, efficient direct-acting antivirals were introduced into clinical practice. However, clearance does not reduce risk end-stage diseases to level observed patients who have never been infected. So, investigation HCV pathogenesis still warranted. Virus-induced changes cell metabolism contribute development HCV-associated pathologies. Here, we studied impact on...
In this study, we continued to study antiherpetic properties of acyclovir 5'-hydrogenphosphonate (Hp-ACV) in cell cultures and animal models. Hp-ACV was shown inhibit the development herpetic infection mice induced by HSV-1/L(2) strain. The compound suppressed replication both ACV-sensitive ACV-resistant HSV-1/L(2)/R strains Vero culture. Viral population resistant (HSV-1/L(2)/R(Hp-ACV)) developed much slower than population. analysis Hp-ACV-resistant clones isolated from...
A series of new 5'-O-carbamate prodrugs AZT have been prepared. The stability in biological media, anti-HIV properties and pharmacokinetic parameters dogs were evaluated. compounds display moderate activity cell culture. After oral administration carbamate IV dogs, both intact prodrug released discovered dog blood. Pharmacokinetic the compound estimated. Half-life (T(1/2)) after was close to that itself, time maximum concentration (T(max)) from two three times longer compared with...
A set of 3′-modified N 4 -alkyl-5-methyl-2′-deoxycytidines has been synthesized and evaluated for biological activity. The replacement the 3′-hydroxyl group with amino, aminoethyl dialkylamino groups significantly enhances antifungal
The emergence of drug-resistant strains pathogenic microorganisms necessitates the creation new drugs. A series uridine derivatives containing an extended substituent at C-5 position as well alkyloxymethyl, alkylthiomethyl, alkyltriazolylmethyl, alkylsulfinylmethyl and alkylsulfonylmethyl uridines were obtained in order to explore their antimicrobial properties solubility. It has been shown that ribonucleoside have magnitude better solubility water compared 2'-deoxy analogues effectively...
Anti-HIV activity and cytotoxicity were tested for novel phosphonate derivatives of AZT, d4T ddA. For the most active was 2′,3′-Dideoxy-2′,3′-didehydrothymidine 5′-isopropylphosphite among AZT highest shown by 2′,3′-Dideoxy-3′-azidothymidine 5′-cyclohexylphosphite.
Biogenic polyamines are ubiquitous compounds. Dysregulation of their metabolism is associated with the development various pathologies, including cancer, hyperproliferative diseases, and infections. The canonical pathway polyamine catabolism includes acetylation spermine spermidine subsequent acetylpolyamine oxidase (PAOX)-mediated oxidation acetylpolyamines (back-conversion) or direct efflux from cell. PAOX considered to catalyze a non-rate-limiting catabolic step. Here, we show that...