A5053610759- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related gene regulation
- Photoreceptor and optogenetics research
- Photochromic and Fluorescence Chemistry
- Genetic Syndromes and Imprinting
- Toxoplasma gondii Research Studies
- Cancer Genomics and Diagnostics
- Renal and related cancers
- Light effects on plants
- RNA and protein synthesis mechanisms
- Electromagnetic Effects on Materials
- Pluripotent Stem Cells Research
- Microbial Natural Products and Biosynthesis
- Tuberculosis Research and Epidemiology
- Geochemistry and Geochronology of Asian Mineral Deposits
- Electromagnetic wave absorption materials
- DNA and Nucleic Acid Chemistry
- Advanced Energy Technologies and Civil Engineering Innovations
Cancer Research UK
2019-2021
University of Cambridge
1984-2021
Shenzhen University
2021
Cancer Research UK Cambridge Center
2018
Chinese Academy of Sciences
2013-2015
Center for Excellence in Molecular Cell Science
2013-2015
Shanghai Institutes for Biological Sciences
2013-2014
MRC Laboratory of Molecular Biology
2013
Estrogen receptor-α (ER) drives tumor development in ER-positive (ER+) breast cancer. The transcription factor GATA3 has been closely linked to ER function, but its precise role this setting remains unclear. Quantitative proteomics was used assess changes the complex response depletion. Unexpectedly, few proteins were lost from absence of GATA3, with only major change being depletion dioxygenase TET2. TET2 binding constituted a near-total subset multiple cancer models, loss associated...
Cytosine methylation is an important epigenetic mark, but how the distinctive patterns of DNA arise remains elusive. For first time, we systematically investigated these can be imparted by inherent enzymatic preferences mammalian de novo methyltransferases in vitro and extent to which this applies cells. In a biochemical experiment, subjected wide variety sequences DNMT3A or DNMT3B then applied deep bisulfite sequencing quantitatively determine sequence for methylation. The data show that...
Abstract Controlling the functional dynamics of DNA within living cells is essential in biomedical research. Epigenetic modifications such as methylation play a key role this endeavour. can be controlled by genetic means. Yet there are few chemical tools available for spatial and temporal modulation modification. Herein, we present small‐molecule approach to modulate with light. The strategy uses photo‐tuneable version clinically used drug (5‐aza‐2′‐deoxycytidine) alter catalytic activity...
TET proteins have been found to play an important role in active demethylation at CpG sites mammals. There are some reports implicating their functions removal of DNA methylation imprint the imprinted regions germline. However, it is not well established whether can also be involved embryonic stem (ES) cells. Here we report that loss caused a significant increase Igf2–H19 region ES We observed variable Peg1 clones devoid proteins, particular differentiated By contrast, did observe Peg3,...
Limbal stem cells are essential for continuous corneal regeneration and injury repair. METTL3-catalyzed N6-methyladenosine (m6A) mRNA modifications involved in many biological processes play a specific role cell regeneration, while the of m6A repair remains unknown. In this study, we generated limbal cell-specific METTL3 knockout mouse model studied repairing caused by alkali burn. The results showed that promotes vivo proliferation migration, leading to fast injury. addition, modification...
Abstract Controlling the functional dynamics of DNA within living cells is essential in biomedical research. Epigenetic modifications such as methylation play a key role this endeavour. can be controlled by genetic means. Yet there are few chemical tools available for spatial and temporal modulation modification. Herein, we present small‐molecule approach to modulate with light. The strategy uses photo‐tuneable version clinically used drug (5‐aza‐2′‐deoxycytidine) alter catalytic activity...
Mycobacterial fatty acid synthase type-I (FAS-I) has an important role in the de novo synthesis of acids, which constitute a major component cell wall. The essentiality FAS-I survival and growth mycobacterium makes it attractive drug target. However, targeted inhibitors against have not been reported yet. Recently, structure from Mycobacterium tuberculosis was solved. Therefore, quest to find potential FAS-I, molecular docking-based virtual screening dynamics simulation were done....
Abstract Cytosine methylation (5mC) is a well-established epigenetic mechanism essential for genomic imprinting, silencing of retrotransposons, and lineage-specific expression developmental genes. This mark extensively remodeled during mammalian development through the action several DNA methyltransferases (DNMT) Ten-Eleven-Translocation (TET) family protein dioxygenases. TET proteins function in de-methylation by catalyzing oxidation 5mC to 5-hydroxymethylcytosine (5hmC) other oxidized...
A number of grains Au-Cu minerals, which are from a sulphurised copper-nickel deposit in North-West China, have been analysed and four species found. They : AuCu, AuCu3, Au3Cu2 nearly pure Au containing few percent Cu. According to the chemical composition we considered that is new mineral.