A5050531186- Peripheral Neuropathies and Disorders
- Prostate Cancer Treatment and Research
- Hereditary Neurological Disorders
- Radiopharmaceutical Chemistry and Applications
- Alzheimer's disease research and treatments
- Peripheral Nerve Disorders
- Myasthenia Gravis and Thymoma
- Neurogenesis and neuroplasticity mechanisms
- Cancer, Lipids, and Metabolism
- Autoimmune Bullous Skin Diseases
- Regulation of Appetite and Obesity
- Lung Cancer Research Studies
- Tryptophan and brain disorders
- Dermatological and Skeletal Disorders
- Complement system in diseases
- Platelet Disorders and Treatments
- Peptidase Inhibition and Analysis
- Systemic Lupus Erythematosus Research
- Bone health and treatments
- Spectroscopy Techniques in Biomedical and Chemical Research
- Multiple Myeloma Research and Treatments
- Skin Diseases and Diabetes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Pain Mechanisms and Treatments
- Nerve injury and regeneration
Fudan University
2021-2025
Huashan Hospital
2021-2025
Shanghai Medical College of Fudan University
2025
Renji Hospital
2017-2021
Shanghai Jiao Tong University
2017-2021
Abstract Background and Aims To investigate the treatment of ofatumumab in autoimmune nodopathy (AN). Methods An open‐label, prospective, observational study was conducted patients with AN. The regimen 20 mg subcutaneously on day 0, 7, 14, 28, subsequently every 4 weeks a total 24 weeks. primary endpoint proportion confirmed clinical improvement. Results All eight (100%) improved at Week 24. median time to improvement 8 (IQR: 7–10) four previously treated rituximab two irregular injections...
Objective To determine if prognostic nutritional index (PNI) and its variation could predict initial response to treatment prognosis in metastatic castration‐resistant prostate cancer (mCRPC) patients treated with Abiraterone (AA). Patients Methods One‐hundred‐twelve chemotherapy pretreated or chemotherapy‐naive were scheduled for systemic AA. PNI levels measured before after one month of AA treatment. Univariate multivariate logistic regression analyses used identify predictive factors...
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a type of autoimmune neuropathy with treatment challenges due to the limitations standard care therapies. Efgartigimod, neonatal Fc receptor antagonist, has shown potential in treating antibody-mediated disorders including CIDP (ADHERE study), but real-world studies on application efgartigimod are still lacking. This study aimed evaluate short-term efficacy and safety five patients China. Clinical effectiveness was assessed...
Objective To determine the prognostic utility of serum chromogranin A (CgA) and neurone‐specific enolase ( NSE ) variations during first 3 months abiraterone acetate AA treatment in patients with metastatic castration‐resistant prostate cancer mCRPC ). Patients Methods The levels CgA, were measured at baseline after 40 . Outcome measures prostate‐specific antigen progression‐free survival PSA ‐ PFS ), radiographic rPFS overall OS Results CgA not correlated P = 0.296). In multivariate...
Introduction: Amyloid transthyretin (ATTR) is divided into either hereditary (ATTRv) or sporadic (ATTRwt) and ATTRv a rare disease transmitted as an autosomal dominant manner. Its global prevalence traditionally estimated 5,000 to 10,000 persons. However, it may be underestimated the exact of in China mainland remains unknown. Methods: The Genome Aggregation database (gnomAD) (containing 125,748 exomes) two genomic sequencing databases--China Metabolic Analytics Project (ChinaMAP) 10588...
To evaluate the efficacy and safety of a low-dose, long-term rituximab regimen in treatment idiopathic CIDP.
To determine the influence of abiraterone Acetate (AA) on neuroendocrine differentiation (NED) in patients with chemotherapy-naive metastatic castration-resistant prostate cancer (mCRPC).We conducted an analysis 115 chemotherapy-naïve mCRPC who would be treated chemotherapy. The serum levels chromogranin A (CgA), neurone-specific enolase (NSE) were measured 67 without AA treatment and 48 after failure treatment, which these markers also 34 before 6 months treatment. Comparative t-test was...
Objective To determine the prognostic utility of serum pre-albumin in metastatic castration-resistant prostate cancer (mCRPC) patients treated with abiraterone (AA).Patients and Methods 112 chemotherapy pretreated or chemotherapy-naive were scheduled for systemic treatment AA.Serum levels measured before after 3 months AA treatment.Univariate multivariate analyses performed to factors that associated PSA progression-free survival (PSA-PFS), radiographic PFS (rPFS) overall (OS).The Harrell...
Background: Brachial plexus magnetic resonance imaging (MRI) is an important noninvasive supplementary diagnostic method of chronic immune peripheral neuropathies, but few MRI studies on the preganglionic nerves have been conducted. This retrospective cross-sectional study aimed to establish a reliable assessment for brachial nerve thickness and use this assess compare characteristics in various types neuropathies.
Abstract Background Amyloid toxicity and glucose metabolic disorders are key pathological features during the progression of Alzheimer’s disease (AD). While hypothalamus plays a crucial role in regulating systemic energy balance, distribution amyloid plaques preoptic, anterior, tuberal, mammillary regions AD mice, particularly across both sexes, remains largely unclear. Our ongoing research aims to explore hypothalamic neuropathology disturbances well-described APP/PS1 mouse model AD....
Docetaxel-based chemotherapy, as the first-line treatment for metastatic castration-resistant prostate cancer (mCRPC), has succeeded in helping quite a number of patients to improve quality life and prolong survival time. However, almost half mCRPC are not sensitive docetaxel chemotherapy initially. This study aimed establish models predict sensitivity with by using serum surface-enhanced Raman spectroscopy (SERS). A total 32 mCPRC who underwent at our center from July 2016 March 2018 were...
Background Refractory chronic inflammatory demyelinating polyneuropathy (CIDP) is a challenging subset of CIDP. It does not respond well to immune therapy and causes substantial disability. A comprehensive understanding its clinical profile, electrophysiological characteristics potential risk factors associated with refractoriness remains be further elucidated. Methods Data in this cross-sectional study was collected reviewed from the Huashan Peripheral Neuropathy Database (HSPN). Included...
The clinical characteristics, auxiliary examinations, skin and neuropathological features of 7 patients who had reticular cyanosis with peripheral neuropathy from the Department Neurology, Huashan Hospital, Fudan University January 2019 to December 2022 were retrospectively analyzed. Among patients, 5 female 2 male.The age onset was (39.8±21.3) years disease duration (2.7±2.3) years. Three acute 4 chronic onset. All limb numbness, weakness in 6 pain cases. Neuroelectrophysiological...
Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role generation of new neurons that contribute to neural circuits responsible for regulating systemic energy balance. The precise coordination gene networks controlling neurogenesis naive and mature tanycytes is essential maintaining homeostasis adulthood. However, our understanding molecular mechanisms signaling pathways govern proliferation differentiation into remains limited. This article aims review...
Objective To determine the influence of abiraterone acetate (AA) on neuroendocrine differentiation (NED) in metastatic castration-resistant prostate cancer (mCRPC) and prognostic predicting value serum NED markers mCRPC patients treated with AA. Methods We conducted an analysis 115 chemotherapy-naive who were chemotherapy Renji hospital from 2013 to 2017. The median age was 70, ranged 65 76 years old. CgA, NSE PSA levels 101.1 ng/ml(78.5-150.0 ng/ml), 13.4 ng/ml(10.5-17.6 ng/ml)and...
Abstract Hypothalamic defects characterized by metabolic disorders influence the progression of Alzheimer’s disease (AD). Recent studies have proposed that tanycytes, radial glial-like cells lining third ventricle wall, participate in energy homeostasis regulation as an important player. However, role tanycytes neurodegenerative diseases such AD is unclear. Our ongoing research aims to investigate morphological and functional changes APP/PS1 mouse model AD. Considering spatial distribution...