A5031711407- Mosquito-borne diseases and control
- Autoimmune and Inflammatory Disorders Research
- Viral Infections and Vectors
- Virology and Viral Diseases
- interferon and immune responses
- Vaccine Coverage and Hesitancy
- Invertebrate Immune Response Mechanisms
- Pneumonia and Respiratory Infections
- Infectious Encephalopathies and Encephalitis
- Influenza Virus Research Studies
- Bacterial Infections and Vaccines
- Hematological disorders and diagnostics
- Respiratory viral infections research
- Aquaculture disease management and microbiota
- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Antimicrobial Peptides and Activities
Westmead Hospital
2012-2020
ABSTRACT The recent global resurgence of arthritogenic alphaviruses, in particular chikungunya virus (CHIKV), highlights an urgent need for the development therapeutic intervention strategies. While there has been significant progress defining pathophysiology alphaviral disease, relatively little is known about mechanisms involved CHIKV-induced arthritis or potential options to treat severe arthritic symptoms associated with infection. Here, we used microcomputed tomographic (μCT) and...
Chikungunya virus (CHIKV) is an arthritogenic alphavirus causing epidemics of acute and chronic arthritic disease. Herein we describe a comprehensive RNA-Seq analysis feet lymph nodes at peak viraemia (day 2 post infection), arthritis 7) disease 30) in the CHIKV adult wild-type mouse model. Genes previously shown to be up-regulated patients were also sequence information was obtained with up ≈8% reads mapping viral genome; however, no adaptive genome changes apparent. Although day 2, 7 30...
Background Cross-sectional serosurveys using IgG antibody to pertussis toxin (IgG-PT) are increasingly being used estimate trends in recent infection independent of reporting biases. Methods/Principal Findings We compared the age-specific seroprevalence various levels IgG-PT cross-sectional surveys systematic collections residual sera from Australian diagnostic laboratories 1997/8, 2002 and 2007 with reference both changes vaccine schedule epidemic cycle, as measured by disease...
A marine-derived compound, abalone hemocyanin, from Haliotis rubra was shown to have a unique mechanism of antiviral activity against herpes simplex virus 1 (HSV-1) infections. In vitro assays demonstrated the dose-dependent and inhibitory effect purified hemocyanin HSV-1 infection in Vero cells with 50% effective dose (ED50) 40 50 nM no significant toxicity. addition, specifically inhibited viral attachment entry by binding selectively surface glycoproteins gD, gB, gC, probably mimicking...
Arthritogenic alphaviruses are mosquito-borne viruses that a major cause of infectious arthropathies worldwide, and recent outbreaks chikungunya virus Ross River (RRV) infections highlight the need for robust intervention strategies. Alphaviral arthritis can persist months after initial acute disease, is mediated by cellular immune responses. A common strategy to limit inflammation pathology dampen overwhelming inflammatory responses modulating proinflammatory cytokine pathways. Here, we...
Zika virus (ZIKV) has recently emerged as an important human pathogen due to the strong evidence that it causes disease of central nervous system, particularly microcephaly and Guillain-Barré syndrome. The pathogenesis disease, including mechanisms neuroinvasion, may include both invasion via blood-brain barrier peripheral (including cranial) nerves. Cellular responses infection are also poorly understood. This study characterizes in vitro laboratory-adapted ZIKV African MR766 two Asian...
Objectives : To estimate the prevalence of serological evidence immunity to measles and rubella in preschool children central southern Sydney (NSW, Australia) with either documented or parentally reported immunization. Methods Geographical cluster random sampling was used select aged between 18 60 months participate present study. Standardized interviews obtained information on each child’s (by parents) immunization status documentary recorded from Personal Health Record. Venous blood...