Stefano Mastrobuoni

ORCID: 0000-0001-9976-4120
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About
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Research Areas
  • Cardiac Valve Diseases and Treatments
  • Aortic Disease and Treatment Approaches
  • Infective Endocarditis Diagnosis and Management
  • Cardiac Structural Anomalies and Repair
  • Transplantation: Methods and Outcomes
  • Mechanical Circulatory Support Devices
  • Cardiac and Coronary Surgery Techniques
  • Cardiac Imaging and Diagnostics
  • Congenital Heart Disease Studies
  • Cardiac, Anesthesia and Surgical Outcomes
  • Aortic aneurysm repair treatments
  • Infectious Aortic and Vascular Conditions
  • Renal Transplantation Outcomes and Treatments
  • Viral Infections and Immunology Research
  • Vascular Procedures and Complications
  • Cardiovascular Issues in Pregnancy
  • Cardiovascular Function and Risk Factors
  • Organ Transplantation Techniques and Outcomes
  • Coronary Artery Anomalies
  • Cardiac pacing and defibrillation studies
  • Cardiac Arrest and Resuscitation
  • Lipoproteins and Cardiovascular Health
  • Anesthesia and Sedative Agents
  • Peripheral Artery Disease Management
  • Organ and Tissue Transplantation Research

Cliniques Universitaires Saint-Luc
2016-2025

UCLouvain
2016-2025

Outcomes Research Consortium
2017

KU Leuven
2015

Harvard University
2014

Clinica Universidad de Navarra
2006-2012

University of Ottawa
2012

Universidad de Navarra
2007-2012

Society of Thoracic Surgeons
2012

University of Pamplona
2006-2010

Objectives: Systemic inflammatory response occurs frequently after coronary artery bypass surgery, and it is strongly correlated with the risk of postoperative morbidity mortality. Recent studies demonstrate that treatment statin associated a significant marked decrease in inflammation-associated variables such as C-reactive protein, cytokines, adhesion molecules. Therefore, we investigated effects preoperative atorvastatin on systemic perioperative cardiopulmonary bypass. Design:...

10.1097/01.ccm.0000201407.89977.ea article EN Critical Care Medicine 2006-02-22

The bicuspid aortic valve (BAV) exists in a wide variety of phenotypes. aim this study was to assess the anatomical characteristics different phenotypes and develop classification system aid surgical repair.

10.1093/ejcts/ezz033 article EN European Journal of Cardio-Thoracic Surgery 2019-01-23

The aim of this study was to evaluate the long-term outcomes following Ross procedure in young adults our institution. All adult patients who received a operation between 1991 and 2014 were included study. Survival analysis regression performed. cohort compared with age-, gender- calendar year-matched general population. Three hundred-and-six (mean age: 41.7 ± 9.7, male: 74.8%, bicuspid aortic valve: 58.5%, valve stenosis: 68%) analysis. There 7 perioperative deaths (2.3%). Nine lost...

10.1093/ejcts/ezv053 article EN European Journal of Cardio-Thoracic Surgery 2015-03-03

Valve sparing reimplantation can improve the durability of bicuspid aortic valve repair compared with subcommissural annuloplasty, especially in patients a large basal ring. This study analyses effect ring size and annuloplasty on setting tricuspid valve.From 1995 to 2013, 382 underwent elective repair. We included only those undergoing or no whom intraoperative transoesophageal echocardiography images were available for retrospective pre- post-repair measurements (n = 323, annuloplasty:...

10.1093/ejcts/ezv050 article EN European Journal of Cardio-Thoracic Surgery 2015-02-26

Postoperative delirium (POD) remains a frequent complication after cardiac surgery, with pre-operative cognitive status being one of the main predisposing factors. However, performing complete neuropsychological testing is challenging. The magnitude frontal electroencephalographic (EEG) α oscillations during general anaesthesia has been related to cognition and could constitute functional marker for brain vulnerability.We hypothesised that features intra-operative α-band activity predict...

10.1097/eja.0000000000001895 article EN European Journal of Anaesthesiology 2023-08-08

Despite the controversy, aortic homograft is supposedly best option in acute infective endocarditis (AIE), due to its resistance reinfection. However, technical complexity and risk of structural deterioration over time have limited utilization. The aim this study was evaluate long-term results for treatment our institution with particular attention predictors survival reoperation.The cohort includes 112 patients who underwent valve replacement an AIE between January 1990 December...

10.1093/ejcts/ezw175 article EN European Journal of Cardio-Thoracic Surgery 2016-05-26

Presence and consequent extent of infection in patients on continuous-flow left ventricular assist devices (CF-LVADs) can be challenging with the current diagnostic tools. The present study sought to demonstrate power 18F-Fluorodeoxyglucose-Positron-Emission Tomography/Computed Tomography (18F-FDG PET/CT) detecting supported CF-LVAD.The 18F-fluorodeoxyglucose-positron-emission tomography/computed tomography CF-LVAD.Between July 2009 April 2016, 61 PET/CT examinations were performed 47...

10.1093/ehjci/jex158 article EN European Heart Journal - Cardiovascular Imaging 2017-05-24

We retrospectively analysed our 20-year experience on surgical treatment of native mitral valve (MV) endocarditis in a single institution using an early and repair-oriented approach.From August 1991 to December 2015, 192 consecutive patients underwent MV surgery for active endocarditis. Of these, 81% (n = 155) had repair while 19% replacement. In-hospital late outcomes were the 2 groups subgroups with without use patch. Study end points overall survival, reoperation valve-related events. The...

10.1093/ejcts/ezy242 article EN European Journal of Cardio-Thoracic Surgery 2018-06-22

Abstract OBJECTIVES Our goal was to analyse the influence of preoperative aortic regurgitation (AR) on necessity cusp repair during valve-sparing reimplantation (VSR). We focused patients with tricuspid valves (TAV) and evaluated impact AR long-term outcomes. METHODS From March 1998 December 2018, a total 512 consecutive underwent VSR at our institution; these, 303 had TAV. The mean age 53 ± 15 years, median follow-up 6.12 years. rate type were analysed based AR. Time-to-event analysis...

10.1093/ejcts/ezaa427 article EN European Journal of Cardio-Thoracic Surgery 2020-11-03

There is no ideal valve substitute for young adults requiring aortic replacement. Multicenter data supporting use of the Ross procedure with respect to long-term postoperative valve-related mortality and reintervention, as well function autograft pulmonary homograft, are needed.To determine clinical echocardiographic outcomes in middle-aged patients undergoing procedure.A retrospective multicenter international cohort study a median follow-up period 9.2 years was conducted 5 experienced...

10.1001/jamacardio.2020.7434 article EN JAMA Cardiology 2021-03-03

Abstract Background Acute Stanford type A aortic dissection (TAAD) is a life-threatening condition. Surgery usually performed as salvage procedure and associated with significant postoperative early mortality morbidity. Understanding the patient’s conditions treatment strategies which are these adverse events essential for an appropriate management of acute TAAD. Methods Nineteen centers cardiac surgery from seven European countries have collaborated to create multicentre observational...

10.1186/s13019-021-01536-5 article EN cc-by Journal of Cardiothoracic Surgery 2021-06-10

To compare long-term outcomes after bicuspid aortic valve (BAV) repair utilizing the Cabrol annuloplasty versus sparing Reimplantation technique.From 1996 to 2018, 340 consecutive patients underwent BAV repair. Eighty and 189 Reimplantation. Exclusion criteria were re-repairs (n = 6), active endocarditis 4), no 41) ring or suture 20). We compared both groups for survival, reoperations, related events recurrent severe regurgitation (AR > 2+). Inverse probability weighting (IPW) was used...

10.1093/ejcts/ezaa471 article EN European Journal of Cardio-Thoracic Surgery 2020-12-14

Objective: Endothelial dysfunction represents a critical early component of organ injury following cardiopulmonary bypass. Recent studies demonstrate that the treatment with atorvastatin is associated significant improvement endothelial function independently its efficacy on cholesterol levels. Therefore, we investigated effects preoperative endothelium after coronary surgery. Methods: Forty patients undergoing surgery were randomized to (20 mg/die; N = 20) or placebo (N 3 weeks before...

10.1016/j.ejcts.2005.09.013 article EN other-oa European Journal of Cardio-Thoracic Surgery 2005-11-05

Prosthetic vascular graft infection (PVGI) remains a severe and challenging complication in surgery with high morbidity mortality rates. Incidence has been reported between 1% 6%. The aim of this study was to report our experience terms general surgical management as well outcome, over 15 years.A retrospective consecutive conducted all patients treated department for PVGI January 2000 December 2015. We analyzed data relative primary operation, duration interval initial infections signs,...

10.1177/1538574418754453 article EN Vascular and Endovascular Surgery 2018-02-08

The progressive increase in the use of implantable electronic devices, vascular access for dialysis and increased life expectancy patients with congenital heart diseases has led recent years to a considerable number right-side infective endocarditis, especially tricuspid valve (TV). Although current guidelines recommend TV repair native endocarditis (TVE), percentage replacements remains very high numerous studies. aim our study is analyse experience treatment TVE reparative approach.

10.1093/icvts/ivae084 article EN cc-by Interdisciplinary CardioVascular and Thoracic Surgery 2024-04-29

Abstract OBJECTIVES Aortic valve-sparing root replacement using the reimplantation technique and mitral valve repair are well-established surgical approaches for treatment of aortic pathologies insufficiency. However, management concomitant diseases with a dual valve-preserving strategy remains poorly described. Therefore, aim this study is to evaluate long-term outcomes sparing surgery repair. METHODS This case series includes all patients that underwent combined at Cliniques Universitaires...

10.1093/icvts/ivaf067 article EN cc-by Interdisciplinary CardioVascular and Thoracic Surgery 2025-03-13
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