A5000309930- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Retinal and Macular Surgery
- Intraocular Surgery and Lenses
- Retinal Development and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Corneal surgery and disorders
- Ocular Infections and Treatments
- Cerebral Venous Sinus Thrombosis
- Ophthalmology and Visual Impairment Studies
- Ocular Oncology and Treatments
- Optical Coherence Tomography Applications
- Retinopathy of Prematurity Studies
- Vascular Malformations Diagnosis and Treatment
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Photoreceptor and optogenetics research
- Angiogenesis and VEGF in Cancer
- Systemic Lupus Erythematosus Research
- Optical Imaging and Spectroscopy Techniques
- Ocular and Laser Science Research
- Neuroscience and Neural Engineering
- Eicosanoids and Hypertension Pharmacology
Loma Linda University
2019-2025
Broward Health
2023-2025
The Retina Center
2023-2025
Florida Atlantic University
2025
Yes Technologies (United States)
2025
Rochester Institute of Technology
2025
Loma Linda University Health Care
2019-2024
University of Florida
2010-2023
Florida International University
2023
Florida College
2007-2017
Intravitreous injections of antivascular endothelial growth factor agents are effective for treating diabetic macular edema (DME) involving the center macula (center-involved DME [CI-DME]) with visual acuity impairment (20/32 or worse). The best approach to patients CI-DME and good (20/25 better) is unknown.To compare vision loss at 2 years among eyes initially managed aflibercept, laser photocoagulation, observation.Randomized clinical trial conducted 91 US Canadian sites 702 adults type 1...
Understanding measurement variability and relationships between measurements obtained on different optical coherence tomography (OCT) machines is critical for clinical trials settings.
To evaluate the integrity of macular and temporomacular vasculature in nonproliferative diabetic retinopathy (NPDR) with noninvasive optical coherence tomography angiography (OCTA) correlate perfusion indices degree NPDR.In this prospective observational cross-sectional study, 102 eyes newly diagnosed NPDR (mild NPDR, 36; moderate 21; severe 13; edema [DME], 32) underwent OCTA. Sixty normal subjects served as control. Degree (based on Early Treatment Diabetic Retinopathy Study criteria) was...
To evaluate the functional and anatomic outcomes of faricimab treatment in patients with neovascular age-related macular degeneration (nAMD) who are unresponsive to other anti-vascular endothelial growth factor (VEGF) therapies.
Introduction Diabetic retinopathy (DR) is a leading cause of blindness globally, emphasizing the urgent need for efficient diagnostic tools. Machine learning, particularly convolutional neural networks (CNNs), has shown promise in automating diagnosis retinal conditions with high accuracy. This study evaluates two CNN models, VGG16 and InceptionV3, classifying optical coherence tomography (OCT) images into four categories: normal, choroidal neovascularization, diabetic macular edema (DME),...
Giant cell arteritis (GCA) affects various ocular structures and potentially leads to vision loss. Traditional therapy involves a tapering regimen of high-dose systemic corticosteroids which are associated with adverse effects, including the risk opportunistic infections such as toxoplasmosis from immune suppression. Tocilizumab, humanised monoclonal antibody directed against interleukin-6 receptor, offers an effective treatment option for GCA. In this report, we detail successful...
Retinal ischemia-induced upregulation of vascular endothelial growth factor (VEGF) leads to proliferation the anterior segment, resulting in neovascular glaucoma.To investigate ciliary epithelium as a possible source VEGF human eyes enucleated for intractable glaucoma.In this proof-of-concept, laboratory-based study, 16 (8 with glaucoma and 8 controls) were investigated.Presence by immunohistochemical analysis (VEGF protein) situ hybridization messenger RNA).In glaucoma, strong...
Angiotensin-converting enzyme 2 (ACE2) is the primary of vasoprotective axis renin angiotensin system (RAS). We tested hypothesis that loss ACE2 would exacerbate diabetic retinopathy by promoting bone marrow dysfunction. ACE2-/y were crossed with Akita mice, a model type 1 diabetes. When comparing -Akita mice to we observed reduction both short-term and long-term repopulating hematopoietic stem cells, shift hematopoiesis toward myelopoiesis, an impairment lineage- c-kit+ stem/progenitor cell...
Purpose To report the biologic effect of intracameral bevacizumab in patients with iris neovascularization secondary to proliferative retinal vasculopathies. Methods Sixteen eyes 15 associated or without neovascular glaucoma vasculopathies received (1.25 mg). Ophthalmic evaluations included Snellen visual acuity (VA), complete ophthalmic examination, fluorescein angiography, and slit lamp photography Main outcome measure was change degree neovascularization. Secondary outcomes angiographic...
Proliferative diabetic retinopathy (PDR) is associated with microvascular complications that cause biochemical changes in the human retina and alter proteome of vitreous humor aqueous (AH).Human AH PDR subjects were collected. Subjects who had surgery for epiretinal membrane or macular hole served as controls. Protein profiles obtained analyzed after running samples on a liquid chromatography-mass spectrometry/mass spectrometry.In humor, 16 unique proteins noted patients, but not Those...
Objective . To prospectively evaluate the effect of intravitreal bevacizumab on aqueous levels interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) in patients with exudative age-related macular degeneration (AMD) correlate clinical outcomes cytokine levels. Methods 30 eyes AMD underwent injection three times at monthly intervals. The samples prior to 1st (baseline) 3rd were analyzed for VEGF IL-6 Subjects subgrouped based upon change central subfield (CSF) thickness SD-OCT 8...
This study determines 'correlation constants' between the gold standard histological measurement of retinal thickness and newer spectral-domain optical coherence tomography (SD-OCT) technology in adult C57BL/6 mice.Forty-eight eyes from mice underwent SD-OCT imaging then were histologically prepared for frozen sectioning with H&E staining. Retinal was measured via 10x light microscopy. images sections standardized to three anatomical sites relative optic nerve head (ONH) location. The ratios...
Early disease detection is emphasized within ophthalmology now more than ever, and as a result, clinicians innovators turn to deep learning expedite accurate diagnosis mitigate treatment delay. Efforts concentrate on the creation of systems that analyze clinical image data detect disease-specific features with maximum sensitivity. Moreover, these hold promise early patients common progressive diseases. DenseNet, ResNet, VGG-16 are among few Convolutional Neural Network (CNN) algorithms have...
Lutein (LUT) and zeaxanthin (ZEA) are currently under investigation in clinical trials as prophylactic nutritional agents for age-related macular degeneration (AMD). However, dose used these is empirical not been investigated vitro studies.In this study, we the dose-response effect of LUT ZEA protecting retinal pigment epithelium (RPE) from oxidative stress, a common underlying pathology AMD.Three thousand cultured human epithelial cells (ARPE-19) were plated 72-well plate after 24 h exposed...
Purpose Retinal ischemia is a pathophysiologic feature of sickle cell retinopathy. Inner retinal thinning retina temporal to the fovea has been reported on spectral-domain optical coherence tomography (SD-OCT) even though clinical examination normal and fluorescein angiography (FA) does not show any capillary dropout. In patient with disease inner SD-OCT FA, new technology OCT (OCTA) showed corresponding area nonperfusion. Methods The underwent visual acuity testing, refraction, slit-lamp...