A5033491215- Retinal Diseases and Treatments
- Acupuncture Treatment Research Studies
- Dietary Effects on Health
- Chemokine receptors and signaling
- Angiogenesis and VEGF in Cancer
- Circadian rhythm and melatonin
- Phagocytosis and Immune Regulation
- Retinal Imaging and Analysis
- Birth, Development, and Health
- Diabetes and associated disorders
- Climate Change and Health Impacts
- Sphingolipid Metabolism and Signaling
- Wound Healing and Treatments
- Mesenchymal stem cell research
- Retinal Development and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinal and Optic Conditions
- Diet and metabolism studies
- Renin-Angiotensin System Studies
- Cardiac Fibrosis and Remodeling
- Health and Medical Education
- Women's cancer prevention and management
- Congenital heart defects research
- Apelin-related biomedical research
- Lipid metabolism and disorders
Indiana University – Purdue University Indianapolis
2014-2025
Indiana University School of Medicine
2014-2025
Hospital Pedro Hispano
2022
University of Alabama at Birmingham
2019
Indiana University
2016-2019
Hypertension Institute
2018
University of Florida
2012-2017
University School
2016
By using pseudorabies virus expressing green fluorescence protein, we found that efferent bone marrow-neural connections trace to sympathetic centers of the central nervous system in normal mice. However, this was markedly reduced type 1 diabetes, suggesting a significant loss marrow innervation. This innervation associated with change hematopoiesis toward generation more monocytes and an altered diurnal release rodents patients diabetes. In hypothalamus granular insular cortex mice...
Angiotensin-converting enzyme 2 (ACE2) is the primary of vasoprotective axis renin angiotensin system (RAS). We tested hypothesis that loss ACE2 would exacerbate diabetic retinopathy by promoting bone marrow dysfunction. ACE2-/y were crossed with Akita mice, a model type 1 diabetes. When comparing -Akita mice to we observed reduction both short-term and long-term repopulating hematopoietic stem cells, shift hematopoiesis toward myelopoiesis, an impairment lineage- c-kit+ stem/progenitor cell...
Electroacupuncture (EA) performed in rats and humans using limb acupuncture sites, LI-4 LI-11, GV-14 GV-20 (humans) Bai-hui (rats) increased functional connectivity between the anterior hypothalamus amygdala mobilized mesenchymal stem cells (MSCs) into systemic circulation. In human subjects, source of MSC was found to be primarily adipose tissue, whereas rodents tissue sources were considered more heterogeneous. Pharmacological disinhibition rat enhanced sympathetic nervous system (SNS)...
Dysregulation of circadian rhythmicity is identified as a key factor in disease pathogenesis. Circadian controlled at both transcriptional and post-transcriptional level suggesting the role microRNA (miRNA) double-stranded RNA (dsRNA) this process. Endonuclease Dicer controls miRNA dsRNA processing, however regulation not known. Here we demonstrate robust diurnal oscillations expression central peripheral clock control systems including suprachiasmatic nucleolus (SCN), retina, liver, bone...
Previously, we showed that mesenchymal stem cells (MSC) can be mobilized into peripheral blood using electroacupuncture (EA) at acupoints, LI-4, LI-11, GV-14, and GV-20. The purpose of this study was to determine whether EA-mobilized MSC could harvested expanded in vitro used as an autologous cell therapy horses. Peripheral mononuclear (PBMC) isolated from young aged lame horses (n = 29) a marked enrichment for MSCs. were 25) administered intravenously dose 50 x 106 24). Treatment resulted...
Diabetic retinopathy is a microvascular disease that results from retinal vascular degeneration and defective repair due to diabetes-induced endothelial progenitor dysfunction.
Cryptococcal meningoencephalitis (CM) remains a common cause of central nervous system infections. Patients usually present with headache, fever, malaise, and altered mental status over several weeks. Signs are often absent, but they may include meningism, papilledema, cranial nerve palsies, depressed level consciousness. Individuals CM can occasionally small vessel vasculitis causing cerebral lesions. The literature regarding patterns cerebrovascular injury in is scarce. We describe case...
Primary cardiac neoplasms are rare, with 3/4 cases being benign. Most malignant sarcomas. Clinically, they present as pseudovalvular obstruction or remote embolism and rarely a paraneoplastic syndrome. Median survival depends on complete resection rather than histologic type. We describe the case of 65-year-old woman who presented to hospital three-month history asthenia, anorexia, weight loss, progressive worsening exertional dyspnea. Transthoracic echocardiogram showed bulky mass in...