A5004366421- Bone health and osteoporosis research
- Bone fractures and treatments
- Sports injuries and prevention
- Bone health and treatments
- Hip and Femur Fractures
- Hip disorders and treatments
- Shoulder Injury and Treatment
- Sports Performance and Training
- Lower Extremity Biomechanics and Pathologies
- Bone Metabolism and Diseases
- Body Composition Measurement Techniques
- Cerebral Palsy and Movement Disorders
- Connective tissue disorders research
- Growth Hormone and Insulin-like Growth Factors
- Sports Dynamics and Biomechanics
- Platelet Disorders and Treatments
- Clinical practice guidelines implementation
- Health Systems, Economic Evaluations, Quality of Life
- Cellular Mechanics and Interactions
- Cardiovascular Effects of Exercise
- Infant Development and Preterm Care
- Birth, Development, and Health
- Lipid metabolism and disorders
- Cleft Lip and Palate Research
- Ultrasound and Hyperthermia Applications
Marian University - Indiana
2023-2025
Indiana University – Purdue University Indianapolis
2015-2024
Indiana University Health
2018-2024
Indiana University Indianapolis
2010-2023
Indiana University
2006-2019
Indiana University School of Medicine
2006-2019
NIHR Oxford Musculoskeletal Biomedical Research Centre
2014
American Physical Therapy Association
2008
St.-Johannes-Hospital Dortmund
2008
Oregon State University
1998-2007
Abstract Introduction A subpopulation (CD44 + /CD24 - ) of breast cancer cells has been reported to have stem/progenitor cell properties. The aim this study was investigate whether the unique ability invade, home, and proliferate at sites metastasis. Methods CD44 CD24 expression determined by flow cytometry. Northern blotting used determine proinvasive 'bone lung metastasis signature' genes. matrigel invasion assay intracardiac inoculation into nude mice were evaluate invasion, homing...
Abstract Physical activity during childhood is advocated as one strategy for enhancing peak bone mass (bone mineral content [BMC]) a means to reduce osteoporosis-related fractures. Thus, we investigated the effects of high-intensity jumping on hip and lumbar spine in children. Eighty-nine prepubescent children between ages 5.9 9.8 years were randomized into (n = 25 boys n 20 girls) or control group 26 18 girls). Both groups participated 7-month exercise intervention school day three times...
The skeleton shows greatest plasticity to physical activity-related mechanical loads during youth but is more at risk for failure aging. Do the skeletal benefits of activity persist with aging? To address this question, we used a uniquely controlled cross-sectional study design in which compared throwing-to-nonthrowing arm differences humeral diaphysis bone properties professional baseball players different stages their careers (n = 103) dominant-to-nondominant controls 94). Throwing-related...
Our aim was to assess BMC of the hip over 8 yr in prepubertal children who participated a 7-mo jumping intervention compared with controls stretching program equal duration. We hypothesized that jumpers would gain more than control subjects. The data reported come from two cohorts separate, but identical, randomized, controlled, school-based impact exercise interventions and reflect those subjects agreed long-term follow-up (N = 57; 33, 24; 47% original participants). assessed by DXA at...
Short-term exercise in growing rodents provided lifelong benefits to bone structure, strength, and fatigue resistance. Consequently, when young may reduce the risk for fractures later life, old adage of "use it or lose it" not be entirely applicable skeleton.The skeleton is most responsive exercise, but low-trauma predominantly occur adults. This disparity has raised question whether exercised-induced skeletal changes during growth persist into adulthood where they have antifracture...
17β-Estradiol (E 2 ) exerts protective effects on right ventricular (RV) function in pulmonary arterial hypertension (PAH). Since acute exercise-induced increases afterload may lead to RV dysfunction PAH, we sought determine whether E allows for superior adaptation after an exercise challenge. We studied echocardiographic, hemodynamic, structural, and biochemical markers of male female rats with sugen/hypoxia (SuHx)-induced hypertension, as well ovariectomized (OVX) SuHx females, or without...
A recent novel application of ultrasound therapy is the treatment bone fractures. The aim this study was to investigate effect on fracture repair produced by a conventional therapeutic unit as used physical therapists.Bilateral midshaft femur fractures were created in 30 adult male Long-Evans rats. Ultrasound commenced first day after and introduced 5 days week for 20 minutes day. Each animal treated unilaterally with active contralaterally inactive ultrasound. Active involved 2-millisecond...
Selective serotonin reuptake inhibitors (SSRIs) treat depression by antagonizing the (5-hydroxytryptamine) transporter (5-HTT). These drugs may also have skeletal effects given presence of functional serotonergic pathways in bone and evidence demonstrating detrimental SSRIs on postmenopausal changes. This study aimed to explore influence an SSRI (fluoxetine hydrochloride) changes associated with estrogen deficiency adult mice.Adult, female, Swiss-Webster mice underwent ovariectomy (OVX) or...
Children with brain injuries or cerebral palsy (CP) comprise a large percentage of pediatric clients served by physical therapists. There is no consensus on what the basic parameters should be for different treatment protocols. A very important parameter intervention that pivotal efficacy dosing. Dosing decisions are complex. To date, minimum doses changing structure and function, activity, participation in children various disabilities unknown. This article describes process outcomes...
Electroacupuncture (EA) performed in rats and humans using limb acupuncture sites, LI-4 LI-11, GV-14 GV-20 (humans) Bai-hui (rats) increased functional connectivity between the anterior hypothalamus amygdala mobilized mesenchymal stem cells (MSCs) into systemic circulation. In human subjects, source of MSC was found to be primarily adipose tissue, whereas rodents tissue sources were considered more heterogeneous. Pharmacological disinhibition rat enhanced sympathetic nervous system (SNS)...
Alendronate (ALN) and risedronate (RIS) are bisphosphonates effective in reducing bone loss fractures associated with postmenopausal osteoporosis. However, it is uncertain how long takes turnover to be re-established after treatment withdrawal, whether this differs between the two drugs. The objective of study was determine time required re-establish normal discontinuation ALN RIS an animal model estrogen-deficiency Two hundred ten, 6-mo-old female Sprague-Dawley rats were ovariectomized 6...
ABSTRACT Skeletal loading enhances cortical and trabecular bone properties. How long these benefits last after cessation remains an unresolved, clinically relevant question. This study investigated long-term maintenance of loading-induced in female C57BL/6 mice the influence a surgically induced menopause on maintenance. Sixteen-week-old animals had their right tibia extrinsically loaded 3 days/week for 4 weeks using mouse tibial axial compression model. Left tibias were not served as...
In this study we examine the consequences of altering Hand1 phosphoregulation in developing neural crest cells (NCCs) mice. Whereas deletion NCCs reveals a nonessential role for craniofacial development and embryonic survival, phosphoregulation, consequently dimerization affinities, results severe mid-facial clefting neonatal death. phosphorylation mutants exhibit non-cell-autonomous increase pharyngeal arch cell death accompanied by alterations Fgf8 Shh pathway expression. Together, our...