A5055995061- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Virus-based gene therapy research
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Cytomegalovirus and herpesvirus research
- Immune cells in cancer
- AI in cancer detection
- Pediatric Hepatobiliary Diseases and Treatments
- Immune Cell Function and Interaction
- Radiomics and Machine Learning in Medical Imaging
- Atherosclerosis and Cardiovascular Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Antenna and Metasurface Technologies
- Breast Cancer Treatment Studies
- Diabetes and associated disorders
- Cancer-related Molecular Pathways
- Metabolism, Diabetes, and Cancer
- Advanced Breast Cancer Therapies
- Intermetallics and Advanced Alloy Properties
- Semiconductor materials and interfaces
- Cancer and Skin Lesions
Asan Medical Center
2017-2025
Ulsan College
2017-2025
University of Ulsan
2017-2025
Korea Advanced Institute of Science and Technology
2018-2024
The lack of an appropriate preclinical model metabolic dysfunction-associated steatotic liver disease (MASLD) that recapitulates the whole spectrum impedes exploration pathophysiology and development effective treatment strategies. Here, we develop a mouse (Streptozotocin with high-fat diet, STZ + HFD) gradually develops fatty liver, steatohepatitis (MASH), hepatic fibrosis, hepatocellular carcinoma (HCC) in context dysfunction. transcriptomic features HFD mice closely reflect those patients...
We propose a theoretical framework to predict the deformation mechanism of γ-TiAl single crystal without lattice defects by combining generalized stacking fault energy and Schmid factor. Our theory is validated against an excellent testbed, nanowire, correctly predicting four major mechanisms, namely, ordinary slip, super twinning, mixed slip/fracture observed during tensile compressive tests along 10 different orientations using molecular dynamics simulations. Interestingly, although are...
Abstract Background Patient-derived xenograft (PDX) models serve as a valuable tool for the preclinical evaluation of novel therapies. They closely replicate genetic, phenotypic, and histopathological characteristics primary breast tumors. Despite their promise, rate successful PDX engraftment is various in literature. This study aimed to identify key factors associated with cancer. Methods We integrated clinicopathological data morphological attributes quantified using trained artificial...
BRAF mutation has been recognized as an important biomarker of colorectal cancer (CRC) for targeted therapy and prognosis prediction. However, sequencing every CRC case is not cost-effective. An antibody specific V600E mutant protein introduced, we thus examined the utility VE1 immunohistochemistry evaluating mutations in CRC.Fifty-one BRAF-mutated CRCs 100 age sexmatched wild-type between 2005 2015 were selected from archives Asan Medical Center. Tissue microarrays constructed stained with...
Background/Aim: Adoptive cell therapy using antigen-specific T cells is a promising treatment modality for cancer patients. Various methods to isolate specific and identify corresponding receptor (TCR) sequences are known. This study aimed TCR from isolated carboxyfluorescein succinimidyl ester (CFSE), which marks proliferating activated cells. Materials Methods: CFSE stained healthy donor peripheral blood mononuclear (PBMCs) were treated with cytomegalovirus (CMV) or Epstein-Barr virus...
Background/Aim: The effectiveness of adoptive T cell therapy for solid tumors remains suboptimal, partly attributed to insufficient infiltration into the tumor site. A promising strategy involves directing cells towards utilizing tumor-specific chemokine receptors. Materials and Methods: We analyzed receptor expression in activated breast lung cancer using Cancer Genome Atlas (TCGA) data. Subsequently, we generated 1G4 receptor-engineered (TCR-T) with CCR10 performed vitro vivo efficacy...
Abstract Breast cancer, categorised into hormone receptor-positive (HR+), HER2- positive (HER2+), and triple-negative (TNBC) subtypes, exhibits varied outcomes based on the number of tumour-infiltrating lymphocytes (TILs). Increased TIL levels are associated with better in HER2+ TNBC, while HR+ individuals high show shorter survival but greater neoadjuvant chemotherapy response. To explore divergent roles across various subtypes their effect immune cell composition, we employed single-cell...
Abstract Background In recent years, the advancement of adoptive cell transfer-based immunotherapies has significantly contributed to evolution cancer treatment. The crucial step in achieving successful treatment lies identification T cells that exhibit reactivity towards tumor-specific antigens. However, heterogeneous composition tumor antigen-specific poses a challenge as there are no standardized biomarkers available for their identification. To overcome this limitation, we investigated...
This report describes a rare case of invasive extramammary Paget disease the vulva with signet ring cell morphology in 58-yr-old woman history carcinoma stomach. was initially misinterpreted as metastatic gastric to because an initial small, superficial biopsy specimen showed infiltration cells dermis without intraepidermal cells. However, surgically resected concordant immunophenotypes both and intradermal components immunoreactivity cytokeratin (CK) 7, CEA, gross cystic fluid protein-15,...
Abstract Background Patient-derived xenograft (PDX) models serve as a valuable tool for the preclinical evaluation of novel therapies. They closely replicate genetic, phenotypic, and histopathological characteristics primary breast tumors. Despite their promise, rate successful PDX engraftment is various in literature. This study aimed to identify key factors associated with cancer. Methods We integrated clinicopathological data morphological attributes quantified using trained artificial...