A5062771484- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Neurogenetic and Muscular Disorders Research
- Cerebral Venous Sinus Thrombosis
- Amyotrophic Lateral Sclerosis Research
- Systemic Sclerosis and Related Diseases
- Metabolism and Genetic Disorders
- Mesenchymal stem cell research
- Traumatic Brain Injury and Neurovascular Disturbances
- Diet and metabolism studies
- Intensive Care Unit Cognitive Disorders
- Parkinson's Disease and Spinal Disorders
- Neurological and metabolic disorders
- Ophthalmology and Eye Disorders
- Neurogenesis and neuroplasticity mechanisms
- Reproductive System and Pregnancy
- Myasthenia Gravis and Thymoma
- Nerve injury and regeneration
- Mitochondrial Function and Pathology
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Biochemical Analysis and Sensing Techniques
- Facial Nerve Paralysis Treatment and Research
- Epilepsy research and treatment
- Systemic Lupus Erythematosus Research
- Atrial Fibrillation Management and Outcomes
Hospital General Universitario Morales Meseguer
2015-2025
Universidad de Murcia
1994-2015
Geneva College
2012
Hospital Universitario Virgen de la Arrixaca
1997-1999
Instituto de Neurologia Y Neurocirugia
1999
To (1) determine the value of recently proposed criteria neuromyelitis optica (NMO) spectrum disorder (NMOSD) that unify patients with NMO and those limited forms (NMO/LF) aquaporin-4 immunoglobulin G (AQP4-IgG) antibodies; (2) investigate clinical significance serologic status in NMO.This was a retrospective, multicenter study 181 fulfilling 2006 (n = 127) or NMO/LF AQP4-IgG 54). myelin oligodendrocyte glycoprotein (MOG-IgG) antibodies were tested using cell-based assays.Patients mainly...
Abstract The objective of this article is to assess the safety intraspinal infusion autologous bone marrow mononuclear cells (BMNCs) and, ultimately, look for histopathological signs cellular neurotrophism in amyotrophic lateral sclerosis (ALS) patients. We conducted an open single arm phase I trial. After 6 months observation, BMNCs were infused into posterior spinal cord funiculus. Safety was primary endpoint and defined as absence serious transplant-related adverse events. In addition,...
Abstract Stem cells are self‐renewable, pluripotent that, in adult life, proliferate by a characteristic asymmetric division which one daughter cell is committed to differentiation whereas the other remains stem cell. These also characterized their ability differentiate into various types under heterotopic environmental influences. In present study, we have explored potential of haematopoietic bone marrow oligodendroglial lineage physiological, active myelinating conditions. We evidence...
Abstract Objective Pivotal trial have shown that patients with multiple sclerosis (MS) receiving ocrelizumab had better outcomes. However, data on in clinical practice are limited. The aim of this study was to evaluate the preliminary safety profile and effectiveness treatment for a real‐world setting. Methods We conducted retrospective including consecutive from nine public hospitals south‐eastern Spain who received after it approved. Results A total 228 MS were included (144...
The 2023 criteria for myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) perform well in adults but have not been assessed children. This prospective observational nationwide study includes children and with demyelinating syndromes or encephalitis, whose serum CSF was found MOG-immunoglobulin G (IgG) positive at Institut d'Investigacions Biomèdiques August Pi i Sunyer-Hospital Clínic of Barcelona (Spain). Exclusion were lack clinical information follow-up <1 year,...
Background The therapeutic landscape in generalized myasthenia gravis (gMG) has been continuously evolving recent years, with over five products approved, each different efficacy, safety, and administration profiles. With the availability of new targeted treatments, physicians are faced challenge decision-making tailored to traditional goals, individual preferences, personal experience, seeking optimal disease control a positive safety profile. In this context uncertainty multiple novel...
Objective we aimed to evaluate the utility of transorbital ultrasonography (TOS) in optic nerve assessment and quantification ON atrophy MS patients, determine whether correlates with disease duration disability measured on Kurtzke Expanded Disability Status Scale (EDSS). Materials methods Prospective, multicentre, blinded cohort study 59 patients diagnosed relapsing-remitting 36 controls. Results When TOS, diameter both right (2.69 ± 0.30 mm cases; 3.20 0.19 controls, P < .0001) left (2.71...
<b><i>Objective:</i></b> To determine the effect of disease-modifying drugs (DMDs) on disease activity rebound in patients discontinuing natalizumab (NTZ). <b><i>Methods:</i></b> Twenty-one with relapsing-remitting multiple sclerosis (RRMS) treated NTZ for ≥1 year and who switched to DMDs (glatiramer acetate [GA] or interferon) were followed up 12 months clinical practice. Clinical outcomes after cessation assessed every 3 1 MRI was performed...
Foreign accent syndrome (FAS) is a little known disorder affecting language which has been described in few cases after acute strokes or traumatic brain injuries, but until now not reported multiple sclerosis (MS). It characterised by the appearance of what perceived to be foreign patient. Although it could included within dysprosodias that accompany motor aphasias, should considered as an entity its own right, since may appear without accompanying aphasia. Aphasia infrequent manifestation...
To examine the use of extra-hospital emergency systems in urgent care stroke patients our region and their influence on time required to reach hospital, needed perform an computerised axial tomography (CAT) scan delay receiving attention from specialist.Samples were collected 232 out total number admitted hospitals. Data about prospectively, included arrival time, CAT specialist devoted attending patient. also gathered different transport systems. A statistical analysis was performed...
Wells syndrome, also known as eosinophilic cellulitis, is a rare dermatosis with approximately 200 cases previously described in the literature. Here, we present case of patient multiple sclerosis syndrome induced by dimethyl fumarate (DMF).
Teriflunomide is a once-daily oral immunomodulator approved for relapsing forms of multiple sclerosis (MS) or relapsing-remitting (RRMS; depending on the local label), based extensive evidence from clinical trials and real-world setting efficacy, tolerability patient-reported benefits. The TERICARE study assessed impact teriflunomide treatment over 2 years health-related quality life (HRQoL) some most common disabling symptoms MS, such as fatigue depression. This prospective observational in...
Depression is one of the most prevalent psychiatric conditions in adulthood, reaching figures around 20%. The methodologies used to study depression are varied, and range from a self-administered test structured assessment. Several studies patients with multiple sclerosis (MS) have been conducted last 20 years, 35% found for depressive symptoms, while disorders less frequent, at approximately 21%.