A5102819351- Magnetism in coordination complexes
- Metal complexes synthesis and properties
- Metal-Organic Frameworks: Synthesis and Applications
- Metal-Catalyzed Oxygenation Mechanisms
- Cancer Cells and Metastasis
- Cancer Treatment and Pharmacology
- Fuel Cells and Related Materials
- Hemoglobinopathies and Related Disorders
- Adenosine and Purinergic Signaling
- Iron Metabolism and Disorders
- Biochemical and Molecular Research
- Electron Spin Resonance Studies
- Signaling Pathways in Disease
- COVID-19 Clinical Research Studies
- Computational Drug Discovery Methods
- Fluorine in Organic Chemistry
- SARS-CoV-2 and COVID-19 Research
- Endoplasmic Reticulum Stress and Disease
- Synthesis and Reactions of Organic Compounds
- Global Maternal and Child Health
- COVID-19 Impact on Reproduction
- HER2/EGFR in Cancer Research
- Parasitic Infections and Diagnostics
- Click Chemistry and Applications
- Lanthanide and Transition Metal Complexes
Dhaka Medical College and Hospital
2024-2025
University of Cincinnati
2022-2023
University of Cincinnati Medical Center
2023
Biomedical Research Foundation
2022
Indian Institute of Technology Kharagpur
2018-2019
Johns Hopkins University
2014-2018
Johns Hopkins Medicine
2014-2018
State University of New York
2009-2012
Stony Brook University
2009-2012
Growing evidence suggests that the majority of tumors are organized hierarchically, comprising a population tumor-initiating, or cancer stem cells (CSCs) responsible for tumor development, maintenance and resistance to drugs. Previously we have shown CD133high/CD44high fraction colon is different from their bulk counterparts at functional, morphological genomic levels. In contrast expressing moderate levels CD133, CD44 CD166, with high combined expression CD133 possessed several...
Background and Purpose Finding new indications for existing drugs, also known as drug repositioning or repurposing, is a powerful approach to accelerate discovery development. The unfolded protein response pathways have been proposed be viable target developing anticancer drugs. Experimental Approach We screened the J ohns H opkins D rug L ibrary inhibitors of prostate cancer cell proliferation identify antiprostate treatments among systematically investigated mechanism underlying activity...
e16475 Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal of gastrointestinal tract, primarily driven by KIT or PDGFRA mutations. Imatinib has transformed GIST treatment; however, resistance typically emerges within 20–24 months, necessitating effective second-line therapies such as sunitinib, regorafenib, ripretinib, and masitinib. Methods: A Bayesian network meta-analysis 17 studies including 2,422 patients evaluated efficacy tyrosine kinase inhibitors...
Ligand backbone alteration leads to different mechanisms for catecholase activity and order of interaction with DNA molecules.
Competitive bridging modes of HO<sup>−</sup> and NCS<sup>−</sup> were explored for four Ni<sup>II</sup>-based coordination aggregates in cubane dicubane topology.
Enforced coordination by NO<sub>3</sub><sup>−</sup>, ClO<sub>4</sub><sup>−</sup> and CF<sub>3</sub>COO<sup>−</sup> groups resulted in the formation of [Cu<sub>2</sub>] (<bold>1</bold>), [Cu<sub>4</sub>] (<bold>2</bold>) [Cu<sub>5</sub>] (<bold>3</bold>) complexes using H<sub>5</sub>L1.
Abstract Simultaneous incorporation of both Co II and III ions within a new thioether S‐bearing phenol‐based ligand system, H 3 L (2,6‐bis‐[{2‐(2‐hydroxyethylthio)ethylimino}methyl]‐4‐methylphenol) formed [Co 5 ] aggregates 4 2 ( μ ‐OH) 1,3 ‐O CCH ) ](ClO ⋅H O 1 CC ). The magnetic studies revealed axial zero‐field splitting (ZFS) parameter, D / hc =−23.6 −24.3 cm −1 , E =0.03 0.00, respectively for . Dynamic data confirmed the complexes as SIMs with U eff /k B =30 K 33 ), τ 0 =9.1×10 −8 s...
The Schiff base ligand HL1 ({2,6-bis(allylimino)methyl}-4-methylphenol) having no coordinating donor arm has been examined for its reaction medium and ancillary bridge dependent reactivity a hierarchical family of CuII complexes. showed unique pattern toward in solution. bridging nature situ generated HO- ions the absence presence externally added carboxylates (RCOO-; R = CF3, C6H5 CH3) utilized to produce complexes {[Cu2(μ-L2)2(H2O)]2[Cu2(μ-L2)2(H2O)2](ClO4)6} (1) (HL2...
Abstract This study aimed to investigate thalassemia awareness and prevention among university students in Bangladesh, with a focus on demographic factors, attitudes, opinions regarding safe marriage influencing their knowledge behavior. Key findings showed that 54% of the participants were female, emphasizing need for targeted educational efforts address gender disparity. Furthermore, 92% unmarried, highlighting importance preventive measures this group. Science exhibited higher levels...
Abstract In vast majority of human cancers, malignant stem cells (CSCs) are responsible for tumor development, maintenance and resistance to drugs. Previously we have shown that colon prostate CSCs not only functionally morphologically different from their bulk counterparts, but themselves may represent heterogeneous phenotypic populations. contrast the major (bulk) cancer expressing low levels CD133 CD44, with a high combined expression these markers, as well lacking CD133, possessed...
<p>Rapamycin and FK506 are macrocyclic natural products with an extraordinary mode of action, in which they form binary complexes FK506-binding protein (FKBP) through a shared FKBP-binding domain before forming ternary their respective targets, mechanistic target rapamycin (mTOR) calcineurin, respectively. Inspired by this, we sought to build rapamycin-like macromolecule library new cellular proteins replacing the effector combinatorial oligopeptides. We developed robust...
<p>Rapamycin and FK506 are macrocyclic natural products with an extraordinary mode of action, in which they form binary complexes FK506-binding protein (FKBP) through a shared FKBP-binding domain before forming ternary their respective targets, mechanistic target rapamycin (mTOR) calcineurin, respectively. Inspired by this, we sought to build rapamycin-like macromolecule library new cellular proteins replacing the effector combinatorial oligopeptides. We developed robust...