A5100325531- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related gene regulation
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- Genomics and Chromatin Dynamics
- Kruppel-like factors research
- RNA Research and Splicing
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Endoplasmic Reticulum Stress and Disease
- Zebrafish Biomedical Research Applications
- Esophageal Cancer Research and Treatment
- Microbial Metabolism and Applications
- Nuclear Receptors and Signaling
- Retinoids in leukemia and cellular processes
- Ferroptosis and cancer prognosis
- Topological and Geometric Data Analysis
- PARP inhibition in cancer therapy
- Data Visualization and Analytics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- ATP Synthase and ATPases Research
- Wnt/β-catenin signaling in development and cancer
- Photorefractive and Nonlinear Optics
Nanjing Agricultural University
2025
Soochow University
2013-2023
Chinese University of Hong Kong, Shenzhen
2022
Peking University
2021
Johns Hopkins Medicine
2014
Johns Hopkins University
2014
University of Oxford
2010
University of Toronto
2010
Structural Genomics Consortium
2010
Abstract Epigenetic alteration of tumor suppression gene is one the most significant indicators in human esophageal squamous cell carcinoma (ESCC). In this study, we identified a novel ESCC hypermethylation biomarker ZNF132 by integrative computational analysis to comprehensive genome-wide DNA methylation microarray dataset. We validated status 91 Chinese Han patients and adjacent normal tissues with target bisulfite sequencing (MTBS) assay. Meanwhile, silencing mediated was confirmed both...
MicroRNAs are a new class of small non-protein-coding RNAs that sometimes function as tumor suppressors or oncogenes. Aberrant expression and structural alteration microRNAs have been reported to be involved in tumorigenesis cancer development. Recently, rs531564/pri-miR-124-1, rs4938723/pri-miR-34b/c, rs7372209/pri-miR-26a-1, rs895819/pre-miR-27a, rs11134527/pri-miR-218 were associated with risks various cancers. In order evaluate the relationship these SNPs esophageal squamous cell...
DNA methylation has been implicated as a promising biomarker for precise cancer diagnosis. However, limited methylation-based biomarkers have described in esophageal squamous cell carcinoma (ESCC). A high-throughput dataset (100 samples) of ESCC from The Cancer Genome Atlas (TCGA) project was analyzed and validated along with another independent (12 the Gene Expression Omnibus (GEO) database. status peripheral blood mononuclear cells leukocytes healthy controls also utilized selection....
Esophageal squamous cell carcinoma (ESCC) is the dominant type of esophageal cancer in East Asian population. MicroRNAs (miRNAs) have been studied to play important roles tumorigenesis. Single nucleotide polymorphisms (SNPs) miRNA lead aberrant expression and structural alteration are hypothesized be involved tumorigenesis development. We conducted a population-based case-control study evaluate association between SNPs miRNAs ESCC risk 1400 cases 2185 matched controls. Four including...
Esophageal cancer is one of the most aggressive cancers in world, 70 % which are from China and esophageal squamous cell carcinoma (ESCC) major histopathological form (>90 %). The single nucleotide polymorphisms (SNPs) mature sequence microRNA (miRNA) (mmSNPs) could cause alteration expression contribute to susceptibility cancers. To evaluate association between mmSNPs ESCC, a case-control study including 773 patients with ESCC 882 gender- age-matched controls was carried out investigate...
Background and Purpose Finding new indications for existing drugs, also known as drug repositioning or repurposing, is a powerful approach to accelerate discovery development. The unfolded protein response pathways have been proposed be viable target developing anticancer drugs. Experimental Approach We screened the J ohns H opkins D rug L ibrary inhibitors of prostate cancer cell proliferation identify antiprostate treatments among systematically investigated mechanism underlying activity...
Background: GTA182 is a second-generation, MTA-cooperative PRMT5 inhibitor developed to selectively target MTAP-null tumors, where MTAP deletion (often co-occurring with CDKN2A loss) creates synthetic lethal vulnerability. Unlike first-generation inhibitors, optimized for high selectivity in MTAP-deleted versus wild-type cells, dose-proportional exposure, and CNS penetration, positioning it as potential best-in-class treatment. currently phase 1 clinical trials advanced solid tumors...
Flufenacet is an aryloxy acetamide herbicide. The potential risks of flufenacet to the aquatic ecosystem remain unclear. In this study, acute toxicity and developmental toxic effects on zebrafish (Danio rerio) were assessed at three different life stages: embryo, larvae, adult. Larvae 3 days post-hatch adult exhibited higher sensitivity compared embryos. 96-hour lethal concentration 50 (LC50) values ranked as embryos (9.79 ± 1.22 mg/L) > adults (4.36 0.56 larvae (3.89 0.98 mg/L),...
DNA methylation-based biomarkers were suggested to be promising for early cancer diagnosis. However, esophageal squamous cell carcinoma (ESCC), especially in Chinese Han populations have not been identified and evaluated quantitatively. Candidate tumor suppressor genes (N = 65) selected through literature searching four public high-throughput methylation microarray datasets including 136 samples totally collected initial confirmation. Targeted bisulfite sequencing was applied an independent...
Non-small cell lung cancer is one of the most common cancers and leading cause death worldwide. Genetic variants in regulatory regions some miRNAs might be involved non-small susceptibility survival. rs12220909 (G/C) genetic polymorphism miR-4293 has been shown to associated with decreased risk esophageal squamous carcinoma. However, influence variation on not reported. In order evaluate potential association between a Chinese population, we performed case-control study among 998 cases 1471...
Prostate cancer is a major burden on public health and cause of morbidity mortality among men worldwide. Drug combination therapy known as powerful tool for the treatment cancer. The aim this study to evaluate synergistic inhibitory mechanisms clofoctol sorafenib in prostate However, molecular phenomenon have not been illuminated clearly. In study, we investigated anti-tumor effects with vitro vivo.The activity mechanism were examined PC-3cells. mRNA protein expression key players ER stress...
Nogo protein, encoded by gene reticulon-4 (RTN4), includes three major isoforms different splicing, named Nogo-A Nogo-B and Nogo-C. proteins play an important role in the apoptosis of cells, especially tumor cells. RTN4 single nucleotide polymorphisms (SNPs) can influence efficiency transcription translation thus being related with individual's predisposition to cancer. The CAA insertion/deletion polymorphism (rs34917480) within 3'-UTR has been reported be associated many cancer types. In...
Abstract Summary: The structural genomics of histone tail recognition web server is an open access resource that presents within mini articles all publicly available experimental structures tails in complex with human proteins. Each article composed interactive 3D slides dissect the mechanism underlying specific sequences and marks. A concise text html-linked to graphics guides reader through main features interaction. This can be used analyze compare binding modes across multiple modules,...
Testis is the one and only location of spermatogenesis sexual hormone production. Spermatogenesis a complicated physiological process regulated by many genes specifically differentially expressed in testis. In this study, Transmembrane Protein 225 (TMEM225), which rat testis, has been identified. TMEM225 was cloned from testis cDNA library mapped to chromosome 8q22 browsing University California Santa Cruz genomic database. It contains an open reading frame with length 696 bp, encoding...
Clear cell renal carcinoma (ccRCC) is a primary pathological subtype of RCC and has poor clinical outcome. Krüppel‑like factors (KLFs), which are zinc‑finger proteins, may be involved in ccRCC development progression. KLFs belong to the family DNA‑binding transcription regulate downstream target genes. cancer development. The present study aimed investigate role prognosis. Cancer Genome Atlas database multifactorial analysis showed that were widely expressed pan‑cancers KLF2 was an...
Background MicroRNAs (miRNAs) are a class of small non-coding RNAs generated from endogenous transcripts that form hairpin structures. The precursor is processed into two mature miRNAs major/minor duplexes. Mature regulate gene expression by cleaving mRNA or repressing protein translation. Numerous have been discovered via deep sequencing. Many produced multiple genome sites. These grouped paralogous families generate the same major within organisms. Currently, no method distinguishing these...