A5049984637- Alzheimer's disease research and treatments
- Trace Elements in Health
- Genetic Neurodegenerative Diseases
- Neurological diseases and metabolism
- Heavy Metal Exposure and Toxicity
- Soybean genetics and cultivation
- Mitochondrial Function and Pathology
- Neurological and metabolic disorders
- Parkinson's Disease Mechanisms and Treatments
- Cancer Cells and Metastasis
- Metabolism and Genetic Disorders
- Metabolomics and Mass Spectrometry Studies
- 3D Printing in Biomedical Research
- Advanced Proteomics Techniques and Applications
- Dementia and Cognitive Impairment Research
- S100 Proteins and Annexins
- Microbial Metabolism and Applications
- Diet and metabolism studies
- Plant nutrient uptake and metabolism
- Liver Disease Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Neurological Disease Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Biotin and Related Studies
- Neurological Disorders and Treatments
Nankai University
2025
University of Auckland
2014-2024
Manchester Academic Health Science Centre
2015-2023
University of Manchester
2015-2023
Cancer Research UK Manchester Institute
2019-2021
Northeast Normal University
2018-2019
Maurice Wilkins Centre
2015-2018
Kunming University of Science and Technology
2017
First People's Hospital of Yunnan Province
2012-2017
Manchester University NHS Foundation Trust
2017
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that currently affects 36 million people worldwide with no effective treatment available. Development of AD follows distinctive pattern in the brain and poorly modelled animals. Therefore, it vital to widen spatial scope study prioritise human brains. Here we show functionally distinct regions display varying region-specific changes protein expression. These provide insights into progression disease, novel AD-related...
Alzheimer's disease (AD) is an age-related neurodegenerative disorder that displays pathological characteristics including senile plaques and neurofibrillary tangles. Metabolic defects are also present in AD-brain: for example, signs of deficient cerebral glucose uptake may occur decades before onset cognitive dysfunction tissue damage. There have been few systematic studies the metabolite content AD human brain, possibly due to scarcity high-quality brain and/or lack reliable experimental...
Widespread brain-copper deficiency in patients with Alzheimer's dementia (red) compared to controls (blue).
Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy with complex microenvironment. Dichotomous tumour-promoting and -restrictive roles have been ascribed to the tumour microenvironment, however effects of individual stromal subsets remain incompletely characterised. Here, we describe how heterocellular Oncostatin M (OSM) - Receptor (OSMR) signalling reprograms fibroblasts, regulates growth metastasis. Macrophage-secreted OSM stimulates inflammatory gene expression in...
Abstract Impairment of brain-glucose uptake and brain-copper regulation occurs in Alzheimer’s disease (AD). Here we sought to further elucidate the processes that cause neurodegeneration AD by measuring levels metabolites metals brain regions undergo different degrees damage. We employed mass spectrometry (MS) measure seven post-mortem nine patients controls, plasma-glucose plasma-copper an ante-mortem case-control study. Glucose, sorbitol fructose were markedly elevated all regions, whereas...
Heart disease is the leading cause of death in diabetic patients, and defective copper metabolism may play important roles pathogenesis cardiomyopathy (DCM). The present study sought to determine how myocardial status key copper-proteins might become impaired by diabetes, they respond treatment with Cu (II)-selective chelator triethylenetetramine (TETA) DCM.
Huntington's disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat in exon 1 of the
Huntington's disease (HD) is a genetically-mediated neurodegenerative disorder wherein the aetiological defect mutation in gene (HTT), which alters structure of huntingtin protein (Htt) through lengthening its polyglutamine tract, thus initiating cascade that ultimately leads to premature death. However, neurodegeneration typically manifests HD only middle age, and mechanisms linking causative brain are poorly understood. Brain metabolism severely perturbed HD, some studies have indicated...
Vitamin B5 (d-pantothenic acid; pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA), through which it plays key roles in myriad biological processes, including many regulate carbohydrate, lipid, protein, and nucleic acid metabolism. In brain, acetyl-CoA necessary for synthesis complex fatty-acyl chains myelin, neurotransmitter acetylcholine. We recently found cerebral pantothenate markedly lowered, averaging ∼55% control values cases...
Sporadic Alzheimer’s disease (sAD) is the commonest cause of age-related neurodegeneration and dementia globally, a leading premature disability death. To date, quest for disease-modifying therapy sAD has failed, probably reflecting our incomplete understanding aetiology pathogenesis. Drugs that target aggregated Aβ/tau are ineffective, metabolic defects now considered to play substantive roles in pathobiology. We tested hypothesis recently identified, pervasive cerebral deficiency...
Eugenol has been widely used in medicine due to its antibacterial, anti-inflammatory, antioxidant, anticancer and analgesic properties. The present study was designed investigate the effects of eugenol on cariogenic properties Streptococcus mutans dental caries development rats. demonstrated significant inhibitory against acid production by S. mutans. synthesis water-insoluble glucans glucosyltransferases reduced eugenol. also markedly suppressed adherence saliva-coated hydroxyapatite beads....
It is critical to study the low nitrogen tolerance in wild soybean with extensive genetic diversity for improving cultivated use efficiency. Focusing on plant young and old leaves could provide new insights research. This compared group control physiological metabolomics changes leaves, respectively, then analyzed differences of these between soybean. aimed a theoretical basis molecular mechanism stress tolerance.Wild was less affected by low-nitrogen than as assessed biomass paraments,...
Several studies of Parkinson's disease (PD) have reported dysregulation cerebral metals, particularly decreases in copper and increases iron substantia nigra (SN). However, few investigated regions outside the SN, fewer measured levels multiple metals across different within same brains, there are no currently-available reports metal dementia (PDD). This study aimed to compare concentrations nine essential brain cases PDD controls. Investigated were: primary motor cortex (MCX); cingulate...
Pantothenic acid (vitamin B5) is an essential trace nutrient required for the synthesis of coenzyme A (CoA). It has previously been shown that pantothenic significantly decreased in multiple brain regions both Alzheimer’s disease (ADD) and Huntington’s (HD). The current investigation aimed to determine whether similar changes are also present cases Parkinson’s dementia (PDD), another age-related neurodegenerative condition, such perturbations might occur these apparently different diseases....
Widespread elevations in brain urea have, recent years, been reported certain types of age-related dementia, notably Alzheimer's disease (AD) and Huntington's (HD). Urea increases these diseases are substantive, approximate magnitude to levels present uraemic encephalopathy. In AD HD, elevated widespread, not only regions heavily affected by neurodegeneration. However, measurements have hitherto Parkinson's dementia (PDD), a condition which shares neuropathological symptomatic overlap with...
Several recent studies have uncovered the presence of widespread urea elevations in multiple neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's dementia (PDD), vascular (VaD), and Huntington's (HD). However, it is currently unknown whether with Lewy bodies also shows these alterations urea. This study aimed to investigate if where perturbed DLB brain.
Emodin is an active herbal component traditionally used in East Asian countries for treating a variety of diseases. The present study investigated the effects emodin on specific virulence factors Streptococcus mutans (S. mutans) vitro and caries development vivo. growth acid production S. were significantly inhibited by (0.5-2 mg/ml). also suppressed synthesis insoluble glucans mutans. Furthermore, topical application reduced incidence severity carious lesions rats. These results suggest...
Type-2 diabetes (T2D) is characterized by chronic hyperglycaemia and glucose-evoked organ damage, displays systemic copper overload, elevated risk of impaired cognitive function, epidemiological links to sporadic Alzheimer's disease (sAD). Contrastingly, sAD exhibits cerebral-glucose uptake, elevation cerebral glucose but not blood levels, widespread cerebral-copper deficiency. We hypothesized that sAD-like brain-metal perturbations would occur in T2D.We measured nine essential elements an...