A5035053309- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- High-Energy Particle Collisions Research
- Neutrino Physics Research
- Dark Matter and Cosmic Phenomena
- Particle Detector Development and Performance
- Black Holes and Theoretical Physics
- Computational Physics and Python Applications
- Particle Accelerators and Free-Electron Lasers
- Atomic and Subatomic Physics Research
- Medical Imaging Techniques and Applications
- Nuclear physics research studies
- Superconducting Materials and Applications
- Cosmology and Gravitation Theories
- Stochastic processes and statistical mechanics
- Magnetic confinement fusion research
- Ionosphere and magnetosphere dynamics
- Radiation Detection and Scintillator Technologies
- Nuclear Physics and Applications
- Advanced SAR Imaging Techniques
- Magnetic Properties and Applications
- Radar Systems and Signal Processing
- Nonlinear Waves and Solitons
- Astrophysics and Cosmic Phenomena
- International Science and Diplomacy
Peking University
2006-2025
State Key Laboratory of Nuclear Physics and Technology
2020-2025
University of South China
2024-2025
Tsinghua University
2012-2025
Henan University Huaihe Hospital and Huaihe Clinical Institute
2025
Henan University
2023-2025
University of Oxford
2003-2024
Institut de Physique Théorique
2024
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2024
CEA Paris-Saclay
2024
We report a naturally-occurring two-dimensional material (graphene that can be viewed as gigantic flat fullerene molecule, describe its electronic properties and demonstrate all-metallic field-effect transistor, which uniquely exhibits ballistic transport at submicron distances even room temperature.
Immune checkpoint blockade, exemplified by antibodies targeting the PD-1 receptor, can induce durable tumor regressions in some patients. To enhance efficacy of existing immunotherapies, we screened for small molecules capable increasing activity T cells suppressed PD-1. Here, show that short-term exposure to small-molecule inhibitors cyclin-dependent kinases 4 and 6 (CDK4/6) significantly enhances T-cell activation, contributing antitumor effects vivo, due part derepression NFAT family...
Evidence concerning the role of Helicobacter pylori infection in development colorectal cancer remains controversial. The authors assessed association H. seroprevalence with risk a large population-based case-control study from Germany 2003-2007. Serum antibodies to general and cytotoxin-associated gene A protein (CagA) were measured 1,712 incident cases 1,669 controls. between was estimated by logistic regression, adjustment for potential confounders stratification age group, sex, anatomic...
Abstract As a master regulator of chromatin function, the lysine methyltransferase EZH2 orchestrates transcriptional silencing developmental gene networks. Overexpression is commonly observed in human epithelial cancers, such as non–small cell lung carcinoma (NSCLC), yet definitive demonstration malignant transformation by deregulated remains elusive. Here, we demonstrate causal role overexpression NSCLC with new genetically engineered mouse models adenocarcinoma. Deregulated silences normal...
The growing computational and storage needs of several scientific applications mandate the deployment extreme-scale parallel machines, such as IBM's BlueGene/L, which can accommodate many 128K processors. In this paper, we present our experiences in collecting filtering error event logs from a 8192 processor BlueGene/L prototype at IBM Rochester, is currently ranked #8 Top-500 list. We analyze collected machine over period 84 days starting August 26, 2004. perform three-step algorithm on...
Using data from the FOCUS experiment we analyze $D^+π^-$ and $D^0π^+$ invariant mass distributions. We measure $D_2^{*0}$ $M_{D_2^{*0}} = (2464.5 \pm 1.1 1.9) \mev$ width $Γ_{D_2^{*0}} (38.7 5.3 2.9) \mev$, $D_2^{*+}$ $ M_{D_2^{*+}} (2467.6 1.5 0.76) Γ_{D_2^{*+}} (34.1 6.5 4.2) \mev$. find evidence for broad structures over background in both neutral charged final state. If each is interpreted as a single L=1, $j_q=1/2$ excited charm meson resonance, masses widths are $M_{1/2}^0 =(2407 21...
Since 2015, with the restart of LHC for its second run data taking, LHCb experiment has been empowered a dedicated computing model to select and analyse calibration samples measure performance particle identification (PID) detectors algorithms. The novel technique was developed within framework innovative trigger experiment, which relies on online event reconstruction most datasets, reserving offline special physics cases. strategy process samples, includes data-processing scheme combining...
Genomic alterations that encourage stem cell activity and hinder proper maturation are central to the development of colorectal cancer (CRC). Key molecular mediators promote these malignant properties require further elucidation galvanize translational advances. We therefore aimed characterize a key factor blocks intestinal differentiation, define its transcriptional epigenetic program, provide preclinical evidence for therapeutic targeting in CRC.Intestinal tissue from transgenic mice...
We have performed a search for CPT violation in neutral charm meson oscillations. While flavor mixing the sector is predicted to be small by Standard Model, it still possible investigate through study of proper time dependence asymmetry right-sign decay rates $D^0\to K^-π^+$ and $\d0b\to K^+π^-$. This related violating complex parameter $ξ$ parameters $x$ $y$: $A_{CPT}\propto{\rm Re} ξy-{\rm Im} ξx$ . Our 95% confidence level limit $-0.0068
The FGFR kinases are promising therapeutic targets in multiple cancer types, including lung and head neck squamous cell carcinoma, cholangiocarcinoma, bladder cancer. Although several kinase inhibitors have entered clinical trials, single-agent efficacy has been modest resistance invariably occurs. We therefore conducted a genome-wide functional screen to characterize mechanisms of inhibition FGFR1-dependent cellular model. Our identified known drivers, such as MET, additional novel...
The successful operation of the LHC provides a great opportunity to study processes where heavy baryons are involved. In this work we mainly weak transitions ${\ensuremath{\Sigma}}_{b}\ensuremath{\rightarrow}{\ensuremath{\Sigma}}_{c}$. Assuming reasonable quark-diquark structure, two light quarks constitute an axial vector, calculate widths semileptonic decay ${\ensuremath{\Sigma}}_{b}\ensuremath{\rightarrow}{\ensuremath{\Sigma}}_{c}e{\ensuremath{\nu}}_{e}$ and nonleptonic modes...
A novel deflation approach to direction of arrival (DOA) estimation for symmetric uniform linear array is proposed in this letter cope with the scenario where both uncorrelated sources and coherent are presented. The first estimated using conventional subspace methods, then their effect eliminated by two methods: one exploits configuration array, other utilizes oblique projection. After deflation, a Toeplitz matrix constructed DOA remaining sources. number resolved our can exceed elements....
Sweet potato (Ipomoea batatas (L.) Lam.) with high yield and diverse nutrients, is the third most important food crop in world. Manganese (Mn) an essential cofactor that plays a critical role development maturation of crop. However, molecular mechanism underlying sweet response to Mn remains unclear. In this study, treatment increased depth yellow color potato, augmented sugar carotenoid accumulation storage roots, accompanied decline plant hormones. Especially, Mn-treated roots displayed...
Antennas fed by waveguides with irregular cross-sections are efficiently simulated through the hybridization of mode-matching (MM) method and higher-order moments (HOMoM). To obtain waveguide modes required in MM method, a 2-D finite element (FEM) is utilized combined hybrid MM/HOMoM which enables proposed to model waveports. The accuracy efficiency demonstrated simulating log-periodic antennas (LPAs) an asymmetric single-ridge slot antenna.
A synapse is the junction across which a nerve impulse passes from an axon terminal to neuron, muscle cell or gland cell. The functions and building molecules of are essential almost all neurobiological processes. To describe synaptic structures functions, we have developed Synapse Ontology (SynO), hierarchical representation that includes 177 terms with hundreds synonyms branches up eight levels deep. associated 125 additional protein keywords 109 InterPro domains these SynO terms. Using...
Using data collected by the high-energy photoproduction experiment FOCUS at Fermilab we performed a Dalitz plot analysis of Cabibbo favored decay D+→K−π+π+. This study uses 53653 Dalitz-plot events with signal fraction ∼97%, and represents highest statistics, most complete for this channel. Results are presented discussed using two different formalisms. The first is simple sum Breit–Wigner functions freely fitted masses widths. It model traditionally adopted serves as comparison already...