A5053038948- Orthopedic Surgery and Rehabilitation
- Wound Healing and Treatments
- Elbow and Forearm Trauma Treatment
- Bone fractures and treatments
- Eicosanoids and Hypertension Pharmacology
- Angiogenesis and VEGF in Cancer
- Melanoma and MAPK Pathways
- Innovations in Medical Education
- Diabetic Foot Ulcer Assessment and Management
- Reconstructive Surgery and Microvascular Techniques
- Reproductive tract infections research
- Cancer-related Molecular Pathways
- Urinary Tract Infections Management
- Inflammatory mediators and NSAID effects
- Antiplatelet Therapy and Cardiovascular Diseases
- Musculoskeletal synovial abnormalities and treatments
- Pressure Ulcer Prevention and Management
- Free Radicals and Antioxidants
- Brain Metastases and Treatment
- Pregnancy and Medication Impact
- Hormonal Regulation and Hypertension
- Musculoskeletal Disorders and Rehabilitation
- Patient-Provider Communication in Healthcare
- Shoulder Injury and Treatment
- Trauma and Emergency Care Studies
Goethe University Frankfurt
2012-2025
University of Chicago Medical Center
2025
University Hospital Frankfurt
2018-2024
Goethe Institute
2011-2023
University Medical Center of the Johannes Gutenberg University Mainz
2017
Johannes Gutenberg University Mainz
2017
University Hospital Heidelberg
2016
Heidelberg University
1994-2016
German Red Cross
2012
Institute for Transfusion Medicine
2012
Cell therapy is a promising option for the treatment of acute or chronic myocardial ischemia. The intracoronary infusion cells imposes potential risk cell clotting, which may be prevented by addition anticoagulants. However, comprehensive analysis effects anticoagulants on function missing.Here, we investigated heparin and thrombin inhibitor bivalirudin bone marrow-derived mononuclear (BMC) functional activity homing capacity.Heparin, but not profoundly dose-dependently inhibited basal...
Polo-like kinase 1 (Plk1) is overexpressed in tumor tissues and its expression level tightly associated with the malignancy of tumors prognosis patients. Thus, Plk1 considered as one most attractive molecular targets for anticancer therapy. Recently, several small molecule inhibitors have been identified characterized, first generation has investigated clinical trials. However, long-term effect downregulation on cells not yet studied. In this work we phenotype HeLa cells, which continuously...
Sepsis is one of the main causes for morbidity and mortality in hospitalized patients. Moreover, sepsis associated complications involving impaired wound healing are common. Septic patients often require surgical interventions that in-turn may lead to further caused by healing. We established a mouse model study delayed during distant septic focus point. For this reason cecal ligation puncture (CLP) was combined with creation superficial on ear. Control animals received same procedure...
Abstract Background Despite new radiotherapeutic strategies, radioresistance in head and neck squamous cell carcinoma (HNSCC) remains a major problem. Preclinical model systems are needed to identify resistance mechanisms this heterogeneous entity. Methods We elucidated the interplay among mitogen‐activated protein kinase (MAPK)‐inhibition, radiation, p53 mutations vitro novel ex vivo derived from vital human HNSCC samples. lines (p53WT/mut) were treated with (MEK)‐inhibitor PD‐0325901...
Epoxyeicosatrienoic acids (EETs) are able to enhance angiogenesis and regulate inflammation that is especially important in wound healing under ischemic conditions. Thus, we evaluated the effect of local EET application on wounds mice.Ischemia was induced by cautherization two three supplying vessels mouse ear. Wounding performed ear days later. Wounds were treated either with 11,12 or 14,15 compared untreated control normal wounds. Epithelialization measured every second day. VEGF, TNF-α,...
Triangular fibrocartilage complex (TFCC) lesions have high clinical relevance. Although multiple studies been done in the past, there is a lack of data after conservative treatment and controversy remains regarding management. The purpose this study was to compare outcome symptomatic TFCC arthroscopic debridement.Between 2012 2017, 33 patients were included. 16 treated conservatively 17 with debridement. average age 41 years (range 18-63). mean follow-up 22.2 months 6-74). Evaluation...
Background Radioresistance is a common feature of head and neck squamous cell carcinoma (HNSCC). We previously showed that the irradiation- activated vascular endothelial growth factor (VEGF)-extracellular signal-regulated kinase (ERK)-axis fundamental for survival resistant tumors. In this study, we examined if treatment with potent multikinase (MK) inhibitors, sorafenib sunitinib, could radiosensitize tumor cells. Methods Cultured HNSCC lines were treated inhibitors subsequently...
Abstract Background Empathy is a key competency and essential for doctor-patient relationships. Studies have proven continuous reduction of empathy in medical students during their study period. The use SPs positively evaluated acquisition real patient communication training has positive effects on empowerment. Therefore, the present focusses impact simulated (SP) vs (RP) empathetic behaviour undergraduate students. Methods prospective evaluation took place 210-minute skills lab unit 3rd...
For acute and chronic soft tissue infections, radical surgical debridement is required considered the gold standard, along with its immediate systemic antibiotic therapy. Treatment local antibiotics and/or antibiotic-containing materials commonly used as an additional tool in clinical practice. Spraying fibrin a newer technique that has been studied for some antibiotics. However, gentamicin, data are not yet available on absorption, optimal application, fate at site transfer of into blood....
Epoxyeicosatrienoic acids (EET) facilitate regeneration in different tissues, and their benefit dermal wound healing has been proven under normal conditions. In this study, we investigated the effect of 11,12 EET on diabetes. We induced diabetes by i.p. injection streptozotocin 2 weeks prior to creation dorsal side mouse ear. was applied every second day wound, whereas control groups received only solvent. Epithelialization monitored intravitally up closure. Wounds were stained for VEGF,...
Abstract Chronic non healing wounds in diabetic patients still impose a major problem modern medicine. Especially additional peripheral vascular disease complicates treatment success these patients. Thus, we analyzed the effects of 11,12 epoxyeicosatrienoic acid (EET) combined model hyperglycemia and ischemia mice. Hyperglycemia was induced by Streptozotozin 2 weeks prior to wounding. 3 days before wound creation suppling vessels moue ear were cautherized for ischemia. Either EET or solvent...
Stem cell transplantation is one of the most promising strategies to improve healing in chronic wounds as systemic administration endothelial progenitor cells (EPC) enhances by promoting neovascularization and homing though a high amount needed. In following study, we analysed whether local application can reduce number EPC needed achieving same beneficial effect on wound healing.Wound after or treatment with was monitored vivo creating standardized dorsum hairless mice measuring closure...
The primary treatment goals for advanced-stage thumb carpometacarpal (CMC) joint osteoarthritis are complete pain relief and restoration of strength. purpose the present study was to introduce a variation abductor pollicis longus (APL) suspension arthroplasty using single looping radial slip from APL tendon around flexor carpi radialis (FCR) combined with RegJoint™ interposition determine its efficacy in CMC osteoarthritis.
In an emergency department, the majority of pediatric trauma patients present because minor injuries. The aim this study was to evaluate temporal changes in age-related injury pattern, mechanism, and surgeries patients.