A5073846586- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Economics and Policy
- COVID-19 Clinical Research Studies
- Family and Patient Care in Intensive Care Units
- Sepsis Diagnosis and Treatment
- Diabetes Treatment and Management
- Gut microbiota and health
- Cardiac Arrest and Resuscitation
- Hemophilia Treatment and Research
- Asthma and respiratory diseases
- Hemodynamic Monitoring and Therapy
- Healthcare Policy and Management
- Anesthesia and Sedative Agents
- Primary Care and Health Outcomes
- Clostridium difficile and Clostridium perfringens research
- Renal function and acid-base balance
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pain Management and Opioid Use
- Thermal Regulation in Medicine
- Neuroscience of respiration and sleep
- Opioid Use Disorder Treatment
- Medication Adherence and Compliance
Institute for Clinical and Economic Review
2021-2025
Sears Holdings (United States)
2025
University of Chicago Medical Center
2023
University of Chicago
2019-2022
Australian Defence Force Academy
2012
Harvard University Press
2010
Harvard Pilgrim Health Care
1999
Harvard University
1999
Abstract Respiratory failure and mortality from COVID-19 result virus- inflammation-induced lung tissue damage. The intestinal microbiome associated metabolites are implicated in immune responses to respiratory viral infections, however their impact on progression of severe remains unclear. We prospectively enrolled 71 patients with critical illness, collected fecal specimens within 3 days medical intensive care unit admission, defined compositions by shotgun metagenomic sequencing,...
Gene therapies delivered through a single administration have revolutionized treatment possibilities for many patients living with serious or fatal conditions such as spinal muscular atrophy, hemophilia and sickle cell disease. However, shadowing the excitement about transformational potential of gene has been widespread concern combination uncertainty in durability their benefits over long term short-term financial shock high prices. As healthcare payment ecosystem prepares growing number...
In acute respiratory distress syndrome (ARDS), dead space fraction has been independently associated with mortality. We hypothesized that early measurement of the difference between arterial and end-tidal CO2 (arterial-ET difference), a surrogate for fraction, would predict mortality in mechanically ventilated patients ARDS.We performed two separate exploratory analyses. first used publicly available databases from ALTA, EDEN, OMEGA ARDS Network trials (N = 124) as derivation cohort to test...
Despite existing therapies, people with lupus nephritis progress to kidney failure and have reduced life expectancy. Belimumab voclosporin are two new disease-modifying therapies recently approved for the treatment of nephritis.A de novo economic model was developed estimate cost-effectiveness these including following health states: "complete response," "partial "active disease" defined by eGFR proteinuria changes, failure, death. Short-term data mean cohort characteristics were sourced...
DISCLOSURES: Funding for this summary was contributed by Blue Cross Shield of MA, California Healthcare Foundation, The Patrick and Catherine Weldon Donaghue Medical Research Arnold Ventures, Kaiser Foundation Health Plan Inc., to the Institute Clinical Economic Review (ICER), an independent organization that evaluates evidence on value health care interventions. ICER's annual policy summit is supported dues from Aetna, America's Insurance Plans, AbbVie, Alnylam, AstraZeneca, Biogen, CA,...
DISCLOSURES: Dr Tice and Mr Sarker received ICER grants during the conduct of study. Moradi, Ms Herce-Hagiwara, Faghim, Agboola, Rind, Pearson reports from Arnold Ventures, Blue Cross Shield MA, California Healthcare Foundation, The Commonwealth Fund, Peterson Center on Healthcare, study; other Aetna, America's Health Insurance Plans, Anthem, AbbVie, Alnylam, AstraZeneca, Biogen, CA, Cambia Services, CVS, Editas, Express Scripts, Genentech/Roche, GlaxoSmithKline, Harvard Pilgrim, Care...
The international pandemic of coronavirus disease 2019 (Covid-19) has caused unprecedented strain on healthcare systems worldwide and threatens to deplete the available supply mechanical ventilators. In addition ventilator allocation protocols, a potential way addressing this problem is sharing, also termed split- or co-ventilation, concept that gained recent attention in anticipation dire equipment shortages. Co-ventilation was initially proposed by Neyman Irvin 2006 as method increasing...
A new US institute for comparative effectiveness research will help patients, clinicians, and policy makers make more informed choices. <b>Sean Tunis</b> <b>Steven Pearson</b> explain why it has been controversial assess its prospects success
This viewpoint discusses cost-effectiveness estimates for EtranaDez, a gene therapy hemophilia B, using the Institute Clinical and Economic Review's (ICER) framework single short-term therapies (SSTs). EtranaDez offers long-term benefits from administration, in contrast to high costs frequent dosing required by current factor IX prophylaxis. However, projected gains health are small relative cost implications of therapy, consequently, how offsets associated with counted has substantial...
Digital health technologies (DHTs) are a broad and rapidly innovating class of interventions with distinctive pathways for development, regulatory approval, uptake reimbursement. Given the unique nature DHTs, existing value assessment frameworks evidence standards such as drugs devices not directly applicable. The framework presented here describes conceptual model associated methods to guide assessments DHTs. seeks accomplish two goals: set that technology developers generate robust on...
The purpose of this article is to describe the process and methods cost-effectiveness analysis for clinicians interested in joining or leading aspects branch evidence-based research. Cost-effectiveness a useful tool policymakers considered starting point discussions fair pricing. Clinicians are important members teams conducting analyses, particularly as it relates integrating their clinical expertise into decisions around design conduct analysis. Their input essential assuring that models...
DISCLOSURES: Ms Beinfeld and Nahn Drs Whittington, Mohammed, Pearson report grants from Arnold Ventures, Kaiser Foundation Health Plan Inc., The Patrick Catherine Weldon Donaghue Medical Research Foundation, Blue Cross Shield of Massachusetts, Commonwealth during the conduct study; other America's Insurance Plans, Anthem, AbbVie, Alnylam, AstraZeneca, Biogen, CA, Cambia Services, CVS, Editas, Express Scripts, Genentech/Roche, GlaxoSmithKline, Harvard Pilgrim, Care Service Corporation,...
Rationale: In patients who are mechanically ventilated, diaphragm thinning on ultrasound is thought to correlate with atrophy and has been associated prolonged intubation. Factors other than atrophy, however, may cause changes in thickness, which confound studies examining thickness over time. Objectives: To determine if the mode of mechanical ventilation or an interruption sedatives have immediate effects measurements adult intensive care unit ventilated. Methods: Adult receiving invasive...