A5101750563- Peroxisome Proliferator-Activated Receptors
- Cholesterol and Lipid Metabolism
- Metabolism and Genetic Disorders
- Lipid metabolism and biosynthesis
- Seed Germination and Physiology
- HIV Research and Treatment
- Digital Holography and Microscopy
- Plant tissue culture and regeneration
- Metabolism, Diabetes, and Cancer
- Cocoa and Sweet Potato Agronomy
- Phytoplasmas and Hemiptera pathogens
- Advanced Fluorescence Microscopy Techniques
- Sphingolipid Metabolism and Signaling
- Tree Root and Stability Studies
- Intramuscular injections and effects
- Lipid Membrane Structure and Behavior
- Greenhouse Technology and Climate Control
- Ziziphus Jujuba Studies and Applications
- Infrared Thermography in Medicine
- Plant Water Relations and Carbon Dynamics
- Endoplasmic Reticulum Stress and Disease
- Cell Image Analysis Techniques
- Diabetic Foot Ulcer Assessment and Management
- Glycosylation and Glycoproteins Research
- Drug Transport and Resistance Mechanisms
Wuhan University
2017-2023
Niemann-Pick C1-like 1 (NPC1L1) is essential for intestinal cholesterol absorption. Together with the cholesterol-rich and Flotillin-positive membrane microdomain, NPC1L1 internalized via clathrin-mediated endocytosis transported to endocytic recycling compartment (ERC). When ERC level decreases, interacts LIMA1 moves back plasma membrane. However, how leaves unknown. Here, we find that, in male mice, intracellular bile acids facilitate transport other organelles, such as endoplasmic...
Abstract Sterol-regulatory element binding proteins (SREBPs) are the key transcriptional regulators of lipid metabolism. The activation SREBP requires translocation precursor from endoplasmic reticulum to Golgi, where it is sequentially cleaved by site-1 protease (S1P) and site-2 releases a nuclear form modulate gene expression. To search for new genes regulating cholesterol metabolism, we perform genome-wide CRISPR/Cas9 knockout screen find that partner (POST1), encoded C12ORF49 ,...
Peroxisomes are actively involved in the metabolism of various lipids including fatty acids, ether phospholipids, bile acids as well processing reactive oxygen and nitrogen species. Recent studies show that peroxisomes can regulate cholesterol homeostasis by mediating transport from lysosomes to endoplasmic reticulum towards primary cilium well. Disruptions peroxisome biogenesis or functions lead peroxisomal disorders usually involve neurological deficits. Peroxisomal dysfunction is also...