A5006778142- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Liver Diseases and Immunity
- RNA modifications and cancer
- Liver Disease and Transplantation
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- Peptidase Inhibition and Analysis
- Gallbladder and Bile Duct Disorders
- Radiomics and Machine Learning in Medical Imaging
- Hepatitis B Virus Studies
- Policing Practices and Perceptions
- Pediatric Hepatobiliary Diseases and Treatments
- Genetic factors in colorectal cancer
- Ferroptosis and cancer prognosis
- Genetic and Kidney Cyst Diseases
- Cancer, Lipids, and Metabolism
- Liver physiology and pathology
- Circular RNAs in diseases
- Criminal Justice and Corrections Analysis
- Colorectal Cancer Surgical Treatments
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
Assistance Publique – Hôpitaux de Paris
2014-2025
Hôpital Beaujon
2017-2025
Université Paris Cité
2017-2025
Inserm
2020-2024
Centre de Recherche sur l'Inflammation
2021-2024
Université Paris-Est Créteil
2024
Hôpitaux Universitaires Henri-Mondor
2024
Université Paris Sciences et Lettres
2023-2024
Hôpital Nord
2023
Centre National de la Recherche Scientifique
2022
Immunotherapies represent a new alternative therapeutic approach for hepatocellular carcinomas (HCCs), and have shown promising results when used in combination therapy. The aim of this study was to evaluate the potential transarterial chemoembolisation (TACE) modulate programmed death-1 (PD-1) death-ligand 1 (PD-L1) expression profiles cohort surgically treated HCCs.A total 82 HCCs from patients who had undergone (n = 32) or not 50) preoperative TACE were included study. Immunohistochemical...
Abstract Primary liver cancer arises either from hepatocytic or biliary lineage cells, giving rise to hepatocellular carcinoma (HCC) intrahepatic cholangiocarcinoma (ICCA). Combined hepatocellular- cholangiocarcinomas (cHCC-CCA) exhibit equivocal mixed features of both, causing diagnostic uncertainty and difficulty in determining proper management. Here, we perform a comprehensive deep learning-based phenotyping multiple cohorts patients. We show that learning can reproduce the diagnosis HCC...
The diagnosis of primary liver cancers (PLCs) can be challenging, especially on biopsies and for combined hepatocellular-cholangiocarcinoma (cHCC-CCA). We automatically classified PLCs routine-stained using a weakly supervised learning method. Weak tumour/non-tumour annotations served as labels training Resnet18 neural network, the network's last convolutional layer was used to extract new tumour tile features. Without knowledge precise malignancies, we then applied an unsupervised...
Background Both Liver Imaging Reporting and Data System (LI-RADS) histopathologic features provide prognostic information in patients with hepatocellular carcinoma (HCC), but whether LI-RADS is independently associated survival uncertain. Purpose To assess the association of categories outcomes solitary resected HCC. Materials Methods This retrospective study included HCC from three institutions examined preoperative contrast-enhanced CT and/or MRI between January 2008 December 2019. Three...
Abstract Purpose: Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare malignancy associated with an overall poor prognosis. We aimed to investigate the immune profile of cHCC-CCA and determine its impact on disease outcome. Experimental Design: performed multicenter study 96 patients cHCC-CCA. Gene expression was analyzed using nCounter PanCancer IO 360 Panel. Densities main cells subsets were quantified from digital slides IHC stainings. Genetic alterations investigated targeted...
With the development of chemotherapy regimens, targeted therapies, and hepatic surgery, survival patients with colorectal liver metastases (CRLM) has dramatically improved. Imaging plays a central role for diagnosis, staging, treatment allocation in these patients. To interpret CRLM on imaging, radiologists must be familiar main imaging features untreated tumors as well modifications induced by systemic their meaning relation to pathological tumor response biology. have same histological...
Abstract Background Quantification of liver surface nodularity (LSN) on routine preoperative CT images allows detection cirrhosis and clinically significant portal hypertension. This study aimed to assess the relevance LSN in assessment operative risks for patients with resectable hepatocellular carcinoma (HCC). Methods All undergoing hepatectomy HCC between 2012 2017 were analysed retrospectively. was assessed at liver–fat interface left lobe images. The feasibility quantification assessed....
Aims According to the last WHO classification, steatohepatitic hepatocellular carcinoma (SH‐HCC) is recognized as a distinct HCC subtype, even though consensual definition still lacking. The objectives of study were carefully describe morphological features SH‐HCC and evaluate its impact on prognosis. Methods results We conducted single‐centre retrospective including 297 surgically resected HCC. Pathological SH criteria (steatosis, ballooning, Mallory–Denk bodies, fibrosis, inflammation)...
The recent outbreak of Zika virus (ZIKV) infection and the associated increased prevalence microcephaly in Brazil underline impact viral infections on embryo fetal development. aim present study is to provide a detailed clinical histopathological disruption caused by ZIKV, with special focus neuropathological findings.A feto-placental examination, as well neurobiological studies were performed three fetuses collected after pregnancy termination between 22 25 weeks gestation (WG), because...