Federica Pedica
A5089141701- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Neuroendocrine Tumor Research Advances
- Hepatocellular Carcinoma Treatment and Prognosis
- Peptidase Inhibition and Analysis
- IgG4-Related and Inflammatory Diseases
- Pediatric Hepatobiliary Diseases and Treatments
- Viral-associated cancers and disorders
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Genetic factors in colorectal cancer
- CAR-T cell therapy research
- Lung Cancer Treatments and Mutations
- Cancer Research and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Glycosylation and Glycoproteins Research
- Microscopic Colitis
- Neuroblastoma Research and Treatments
- RNA modifications and cancer
- Inflammatory Bowel Disease
- Drug-Induced Hepatotoxicity and Protection
- Gastric Cancer Management and Outcomes
IRCCS Ospedale San Raffaele
2022-2025
Vita-Salute San Raffaele University
2016-2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2017-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2017-2024
San Raffaele University of Rome
2016-2024
Dutch Colorectal Cancer Group
2023
Collaborative Group (United States)
2023
University of Verona
2009-2016
King's College Hospital
2015
Ospedale Maggiore
2007
A growing body of evidence suggests that non-viral hepatocellular carcinoma (HCC) might benefit less from immunotherapy.We carried out a retrospective analysis prospectively collected data consecutive patients with advanced HCC, treated atezolizumab plus bevacizumab, lenvatinib, or sorafenib, in 36 centers 4 countries (Italy, Japan, Republic Korea, and UK). The primary endpoint was overall survival (OS) bevacizumab versus lenvatinib. Secondary endpoints were progression-free (PFS) OS PFS...
Some patients experience pulmonary sequelae after SARS-CoV-2 infection, ranging from self-limited abnormalities to major lung diseases. Morphological analysis of tissue may help our understanding pathogenic mechanisms and provide consistent personalised management. The aim this study was ascertain morphological immunomolecular features tissue. Transbronchial cryobiopsy carried out in with persistent symptoms computed tomography suggestive residual disease recovery infection. 164 were...
Liver metastases are associated with poor response to current pharmacological treatments, including immunotherapy. We describe a lentiviral vector (LV) platform selectively engineer liver macrophages, Kupffer cells and tumor-associated macrophages (TAMs), deliver type I interferon (IFNα) metastases. Gene-based IFNα delivery delays the growth of colorectal pancreatic ductal adenocarcinoma in mice. Response is TAM immune activation, enhanced MHC-II-restricted antigen presentation reduced...
Titanium dioxide (TiO2) is widely used in pharmaceuticals preparations, cosmetics, and as a food additive (E171). It contains microparticles fraction of nanoparticles (NPs) which can be absorbed systemically by humans after ingestion. Increasing concern has been aroused about the impact oral exposure to TiO2 NPs from dietary non-dietary sources on human health. In spite several toxicological studies conducted recent years, solid risk assessment E171 not satisfactorily achieved. We...
[18F]Fluorodeoxyglucose (18F-FDG) PET/CT is increasingly used to assess organ involvement and response treatment in IgG4-related disease (IgG4-RD), but clear correlations between 18F-FDG uptake activity have not been established yet. We aimed correlate the intensity distribution of with validated clinical, serological immunological parameters IgG4-RD activity.Twenty patients active underwent a baseline PET/CT. Ten repeated after immunosuppressive treatments. tissue was measured using...
Abstract Context.—Pancreatic endocrine neoplasms (PENs) are diagnostically challenging tumors whose natural history is largely unknown. Histopathology allows the distinction of 2 categories: poorly differentiated high-grade carcinomas and well-differentiated neoplasms. The latter include more than 90% PENs clinical behavior varies from indolent to malignant cannot be predicted by their morphology. Objectives.—To review literature report on additional primary material about clinicopathologic...
Lenvatinib has been approved in Italy since October 2019 as a first-line therapy for advanced hepatocellular carcinoma (HCC) and to date data on effectiveness safety of lenvatinib are not available our region. To fill this gap, we performed multicentric analysis the real-world treatment outcomes with propensity score matching cohort Italian patients unresectable HCC who were treated either sorafenib or lenvatinib.To evaluate primary clinical practice 288 such recruited 11 centers Italy. A...
Colorectal tumours are often densely infiltrated by immune cells that have a role in surveillance and modulation of tumour progression but burdened immunosuppressive signals, which might vary from primary to metastatic stages. Here, we deployed multidimensional approach unravel the T-cell functional landscape colorectal cancers (CRC) liver metastases, genome editing tools develop CRC-specific engineered T cells.We paired high-dimensional flow cytometry, RNA sequencing immunohistochemistry...
Cholangiocarcinoma (CCA) is still a deadly tumour. Histological and molecular aspects of thioacetamide (TAA)-induced intrahepatic CCA (iCCA) in rats mimic those human iCCA. Carcinogenic changes therapeutic vulnerabilities may be captured by investigations bile, where we performed bile proteomic metabolomic analyses that help discovery yet unknown pathways relevant to iCCA.Cholangiocarcinogenesis was induced (TAA) mice (JnkΔhepa + CCl4 DEN model). We from control CCA-bearing rats....