A5056444345- Plant Molecular Biology Research
- Photosynthetic Processes and Mechanisms
- Cancer-related Molecular Pathways
- Genomics and Chromatin Dynamics
- DNA Repair Mechanisms
- Light effects on plants
- Plant tissue culture and regeneration
- Plant Gene Expression Analysis
- Photoreceptor and optogenetics research
- PI3K/AKT/mTOR signaling in cancer
- Slime Mold and Myxomycetes Research
- Peroxisome Proliferator-Activated Receptors
- Plant Parasitism and Resistance
- Plant and Biological Electrophysiology Studies
- Cancer, Hypoxia, and Metabolism
- Chronic Myeloid Leukemia Treatments
- Plant Reproductive Biology
- Cancer, Lipids, and Metabolism
- Microtubule and mitosis dynamics
Royal Holloway University of London
2017-2024
University of Warwick
2021-2023
Abstract The rapidly proliferating cells in plant meristems must be protected from genome damage. Here, we show that the regulatory role of Arabidopsis RETINOBLASTOMA RELATED ( RBR ) cell proliferation can separated a novel function safeguarding integrity. Upon DNA damage, and its binding partner E2 FA are recruited to heterochromatic γH2 AX ‐labelled damage foci an ATM ‐ ATR ‐dependent manner. These lesions more dispersedly occupied by conserved repair protein, At BRCA 1, which also...
The DNA of all organisms is constantly damaged by physiological processes and environmental conditions. Upon persistent damage, plant growth cell proliferation are reduced. Based on previous findings that RBR1, the only Arabidopsis homolog mammalian tumor suppressor gene retinoblastoma, plays a key role in damage response plants, we unravel here network RBR1 interactors under stress This led to identification homologs every DREAM component Arabidopsis, including previously not recognized...
Plant growth flexibly adapts to environmental conditions. Growth initiation itself may be conditional a suitable environment, while the most common response of plants adverse conditions is inhibition. Most our understanding about inhibition comes from studies on various plant hormones, less known signaling mechanisms involved. The mitogen-activated protein kinase (MAPK) cascades are central signal transduction pathways in all eukaryotes and their roles stress responses well-established,...
Maintaining stable and transient quiescence in differentiated stem cells, respectively, requires repression of the cell cycle. The plant RETINOBLASTOMA-RELATED (RBR) has been implicated maintenance, presumably by forming repressor complexes with E2F transcription factors. Surprisingly we find that mutations all three canonical E2Fs do not hinder cycle, but similarly to RBR silencing, result hyperplasia. Contrary growth arrest occurs when exit from proliferation differentiation is inhibited...
ABSTRACT Plants rapidly respond to environmental changes ensure an optimal balance between growth and survival with intact genome. Here, we show that a DNA damage response gene, which named LIFERING , is under the direct independent regulation of ATM/ATR-SOG1 RBR pathways. We demonstrate upon plays essential role in maintaining cell proliferation death. Downstream RBR, it required maintain proliferation, damaging agents initiates death accompanied by rapid elongation differentiation transit...
Abstract Maintaining stable and transient quiescence in differentiated stem cells, respectively, requires repression of the cell cycle. The plant RETINOBLASTOMA-RELATED (RBR) has been implicated maintenance, presumably by forming repressor complexes with E2F transcription factors. Surprisingly we find that mutations all three canonical E2Fs do not compromise cycle, but similarly to RBR silencing, result overproliferation. Contrary growth arrest upon when exit from proliferation...