The association of adipocyte-derived proteins, adiponectin and leptin, with the degree coronary atherosclerosis has not been well elucidated. This study aimed to determine relationship between serum leptin presence atherosclerosis.Seventy patients 20 matched controls were recruited. Angiographic evaluation was carried out by assessing three atherosclerotic indices, severity (transverse disease), extent (longitudinal pattern (lesion complexity).The independent predictors larger waist/hip...

Abstract Background Acute lymphoblastic leukemia (ALL) is a heterogeneous cancer marked by rapid growth of immature lymphoid cells in the bloodstream, bone marrow, and other body tissues. Objective To suggest role different genetic variables pathogenesis clinical behavior ALL patients, present study aims to assess possible prognostic impact CTBP2 CASP8AP2 pediatric B-ALL patients. Patients Methods This included 43 individuals who were recently diagnosed with B-ALL, type leukemia, 20 healthy...

Analgesics had been suspected of impairing various immune functions either directly or indirectly. Our primary objective was to compare the effects intravenous (IV) morphine, tramadol, and ketorolac on stress responses in patients who underwent modified radical mastectomy.Sixty randomly assigned receive IV morphine 5 mg (group M, n=20), tramadol 100 T, 60 K, n=20) at end surgery.Serum cortisol, prolactin were measured immediately, 40 minutes, 24 hours postoperatively. Expressions peripheral...

We evaluated the significance of genes, defined as DRB1*04 or DRB1*01, in rheumatoid arthritis (RA) patients. focused on role genetic and serologic markers to predict disease activity destructive process joints.Sixty patients with RA were examined. Radiographic changes by (Larsen score) was measured score 28 (DAS28). The analyzed were: erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), factor (RF), anti-cyclic citrullinated peptides (anti-CCP2) HLA-DRB1 alleles typed PCR.In this...

We have analyzed t(12;21)(p13:q22) in an attempt to evaluate the frequency and prognostic significance of TEL-AML1 fusion gene patients with childhood CD 10 positive B-ALL by fluorescence situ hybridization (FISH). Also, we monitored value this as a minimal residual disease (MRD).All bone marrow samples eighty diagnosed South Egypt Cancer Institute were evaluated (FISH) for t(12;21) newly cases after morphological complete remission (MRD). determined represented course survival.TEL-AML1 was...

Background: The etiology of acute myeloid leukemia (AML) is heterogeneous and has been associated with several risk factors; tumor escape mechanism one the major factors. In this study, we tried to investigate role T-reg cells T- helper cytokines mainly IL-35, IL-17 in pathogenesis AML by determining IL-35 levels different groups patients. Methods: For purpose, 70 adult patients 20 healthy controls were studied for blood level. From total 35 newly diagnosed (ND) complete remission...

In a prospective study, the polymorphism of oestrogen receptor β gene was investigated in nonobstructive azoospermia patients. Ninety infertile patients with diagnosed after two semen analysis, 2 weeks apart and negative testicular sperm extraction during intracytoplasmic injection, 60 fertile men as controls were enrolled study. Semen hormonal profile allele-specific PCR reaction performed to detect variants RsaI for all controls. The mean patient's age significantly lower than (P < 0.05)....

Warfarin is a common oral anticoagulant, but the dose needed for each patient can vary by as much 20 times due to both environmental and genetic factors.Some of most important targets warfarin include vitamin K epoxide reductase complex 1 (VKORC1) gene.This study investigated effect VKORC1 gene on response using real-time PCR in total 100 warfarin-treated Egyptian heart patients 40 controls.This confirmed association SNP rs9934438 with response.The analysis identified presence 26% homozygous...

Background:Immunonutrition not only a nutritional supply for patients but it is therapy which should be started as early possible especially in expected malnutrition following gastrointestinal cancer surgery. Objectives:To evaluate the effect of immunonutrition on postoperative complications undergoing Patient and Methods:A prospective randomized trial was carried out 45 who were chosen classified randomly into three groups each them included 15 followings: Group I received total parenteral...

Background: It is the basic duty of all healthcare professionals to relieve pain, and most important indication for treating pain after surgery humanitarian.Objectives: Comparing effects intravenous morphine, tramadol ketorolac on post operative in patients undergoing modified radical mastectomy Study design: A randomized, double blind trial.Methods: Sixty randomly were assigned receive either IV morphine 5mg (Group I, n = 20), 100 mg II, or 60 III, 20) at end surgery.Assessment parameters...

<h3>Background and Aim</h3> Platelets antigens, Anti-platelets antibodies, serum leptin measurement may be important in defining the pathogenesis of thrombocytopenic states. <h3>Methods</h3> In this study we measured platelets CD41, CD61, CD62P, IgG, IgM by flowcytometry ELISA 20 children diagnosed as ITP normal control. <h3>Results</h3> We observed That there were no significant difference white blood cells count, hemoglobin concentration between patients controls. count was significantly...

Background:Recently, the adipocyte derived proteins; adiponectin and leptin, have been found to be associated with obesity, type 2 diabetes, insulin resistance, hyperinsulinemia, dyslipidemia presence of coronary artery disease.However, association these proteins degree atherosclerosis has not well elucidated.Objectives: To determine relationship between serum leptin levels atherosclerosis.Methods: Seventy patients performing diagnostic angiography in our catheterization laboratory for...

Abstract Background: The Ten-Eleven Translocation 1 gene (TET1) is a member of the TET methyl cytosine dioxygenase family enzymes (TET1, TET2, and TET3). TET1 has contrasting roles in myeloid lymphoid transformation being either an oncogene or tumor suppressor. This work aimed to study expression level acute leukemia patients its correlation with clinical pathological criteria these patients. Patients &amp; methods: was conducted on 73 Bone marrow samples were analyzed using Real Time PCR...

Abstract Background: The Ten-Eleven Translocation 1 gene (TET1) is a member of the TET methyl cytosine dioxygenase family enzymes (TET1, TET2, and TET3). TET1 has contrasting roles in myeloid lymphoid transformation being either an oncogene or tumor suppressor. This work aimed to study expression level acute leukemia patients its correlation with clinical pathological criteria these patients. Patients &amp; methods: was conducted on 73 Bone marrow samples were analyzed using Real-Time PCR...