A5035914308- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Market Dynamics and Volatility
- Statistics Education and Methodologies
- Sports Analytics and Performance
- Financial Risk and Volatility Modeling
- Cardiovascular Disease and Adiposity
- Sleep and related disorders
- Cardiovascular and Diving-Related Complications
- Innovations in Educational Methods
- Immune cells in cancer
- Financial Markets and Investment Strategies
- Trace Elements in Health
- International Business and FDI
- Terrorism, Counterterrorism, and Political Violence
- Tracheal and airway disorders
- Cancer, Hypoxia, and Metabolism
- Vasculitis and related conditions
- Sarcoidosis and Beryllium Toxicity Research
- Lymphatic Disorders and Treatments
- Decision-Making and Behavioral Economics
- Urticaria and Related Conditions
- Respiratory Support and Mechanisms
- Stock Market Forecasting Methods
- Risk Management in Financial Firms
St. Vincent's University Hospital
2013-2025
University of Limerick
2011-2024
University College Dublin
2009-2024
GTx (United States)
2019
University Hospital Galway
2015-2016
St Thomas' Hospital
2015
AstraZeneca (United Kingdom)
2012
German Institute for Economic Research
2009
Acute intestinal inflammation involves early accumulation of neutrophils (PMNs) followed by either resolution or progression to chronic inflammation. Based on recent evidence that mucosal metabolism influences disease outcomes, we hypothesized transmigrating PMNs influence the transcriptional profile surrounding mucosa. Microarray studies revealed a cohort hypoxia-responsive genes regulated PMN-epithelial crosstalk. Transmigrating rapidly depleted microenvironmental O2 sufficiently stabilize...
Nitric oxide (NO(*)) competitively inhibits oxygen consumption by mitochondria at cytochrome c oxidase and S-nitrosates thiol proteins. We developed mitochondria-targeted S-nitrosothiols (MitoSNOs) that selectively modulate protect mitochondrial function. The exemplar MitoSNO1, produced covalently linking an S-nitrosothiol to the lipophilic triphenylphosphonium cation, was rapidly extensively accumulated within mitochondria, driven membrane potential, where it generated NO(*) S-nitrosated...
Mitochondrial biogenesis occurs in response to increased cellular ATP demand. The mitochondrial electron transport chain requires molecular oxygen produce ATP. Thus, generation after results demand that must be matched by a corresponding increase supply. We found overexpression of peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha), which increases primary skeletal muscle cells, leads expression cohort genes known regulated the dimeric hypoxia-inducible factor...
Abstract Hypoxia is a feature of the microenvironment in number chronic inflammatory conditions due to increased metabolic activity and disrupted perfusion at inflamed site. contributes inflammation through regulation gene expression via key oxygen-sensitive transcriptional regulators including hypoxia-inducible factor (HIF) NF-κB. Recent studies have revealed high degree interdependence between HIF NF-κB signaling; however, relative contribution each hypoxia-induced remains unclear. In this...
Hypoxia and inflammation are coincidental events in a diverse range of disease states including tumor growth, ischemia, chronic inflammation. contributes to the development inflammation, at least part through activation and/or potentiation NF-kappaB, master regulator genes involved innate immunity, apoptosis. NF-kappaB can be activated two distinct signaling pathways termed canonical noncanonical pathways, respectively. The pathway is IKKalpha/beta/gamma complex, while involves NIK-mediated...
Obstructive sleep apnoea (OSA) is associated with significantly increased risk of cardiovascular disease. Carotid ultrasonography and retrospective, uncontrolled, coronary imaging studies have suggested an association OSA subclinical atherosclerosis, but there a lack prospective, controlled directly evaluating the relationship occult artery We performed computed tomographic angiography inpatient-attended on cohort otherwise healthy males attending our laboratory, compared plaque volume...
Study Objectives:Resource limitations have raised interest in portable monitoring systems that can be used by specialist sleep physicians as part of an overall strategy to improve access the diagnosis apnea. This study validates a combined electrocardiogram and oximetry recorder (Holter-oximeter) against simultaneous polysomnography for detection
Side-effects directly due to the nasal mask are common in patients with obstructive sleep apnoea syndrome (OSAS) commencing continuous positive airway pressure (CPAP). Recently, pillows have been designed overcome these issues. Limited evidence exists of benefits and effectiveness devices. Twenty-one (19 male, 49±10years) established diagnosis OSAS [apnoea/hypopnoea index (AHI): 52±22] who had a successful CPAP titration were commenced on therapy (10±2cmH2O), randomized 4weeks pillow (P)...
Purpose – The purpose of this paper is to present an exploratory study employee voice and silence in international auditing firms. authors examine two key questions: what the propensity employees training speak up on workplace problems how would management react speaking problems? Design/methodology/approach compare contrast views contracts with including partners. Semi-structured interviews were carried out eight managers/partners 20 working six large firms Ireland. Findings find that have...
Abstract Background The relationship between sleep and arrhythmias is well established. Furthermore, the association obstructive apnea (OSA) bradyarrhythmias described. However, only a few cases of observed during rapid eye movement (REM) or REM sleep-related bradyarrhythmia syndrome, as it known, have been documented in literature. Case Summary Here, we report another example this syndrome. This was diagnosed polysomnography middle-aged male independent OSA. Several pauses, up to 5.7...
ABSTRACT This paper examines the long‐run relationship between implied and realised volatility for a sample of 16 FTSE‐100 stocks. We find strong evidence long‐memory, fractional integration in equity show that this long‐memory characteristic is not an outcome structural breaks experienced during period. Fractional cointegration shown using recently developed rank tests by Robinson Yajima (2002). The predictive ability individual options also examined composite estimates are to contain...
Bilateral investment treaties ( BIT s) are legal instruments used by developing and transition countries to provide investor protection and, extension, promote higher levels of inward foreign direct FDI ). While the link between s has been extensively studied, little is known about impact on different forms investment. Motivated this observation, we examine effects vertical horizontal . We find that more positively related than also tend act as stronger substitutes for better institutions in...
In this article prediction markets are presented as an innovative technology that can facilitate effective risk communication. The application of in context is opportunity to reconcile the disparate approaches currently discussed communication literature. We demonstrate control mutuality uniquely achieved through use market mechanism and it thus some cases optimal for both public private sector organisations.