A5002991263- COVID-19 Clinical Research Studies
- Cancer Immunotherapy and Biomarkers
- Glycosylation and Glycoproteins Research
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- SARS-CoV-2 and COVID-19 Research
- Asthma and respiratory diseases
- Reproductive System and Pregnancy
- Long-Term Effects of COVID-19
- Virus-based gene therapy research
- Preterm Birth and Chorioamnionitis
- Hepatocellular Carcinoma Treatment and Prognosis
- Xenotransplantation and immune response
- Cancer Genomics and Diagnostics
- Trace Elements in Health
- Cancer, Stress, Anesthesia, and Immune Response
- T-cell and B-cell Immunology
- Liver physiology and pathology
- Systemic Lupus Erythematosus Research
- Multiple Sclerosis Research Studies
- Dermatology and Skin Diseases
- Nonmelanoma Skin Cancer Studies
- IL-33, ST2, and ILC Pathways
Columbia University Irving Medical Center
2023-2025
Isfahan University of Medical Sciences
2016-2022
Shiraz University of Medical Sciences
2016-2018
Coronavirus disease 2019 (COVID-19), an acute respiratory infection, is largely associated with dysregulation and impairment of the immune system. This study investigated how system changes were related to severity in COVID-19 patients. The frequencies different cells levels pro- anti-inflammatory cytokines whole blood participants determined by flow cytometry enzyme-linked immunosorbent assay, respectively. values other inflammatory agents also studied. In late recovery stage, unlike CD56...
Xenotransplantation of pig organs is a promising solution to the organ shortage; however, rejection remains major obstacle. Pig-to-human decedent transplantation provides an opportunity study immune barriers xenotransplantation experimentally. We tracked donor-reactive T cell dynamics in 61-day pig-to-human thymokidney xenotransplant. Xenogeneic clones (XDRTCCs) identified using high-throughput TCRB CDR3 sequencing expanded markedly peripheral blood association with apparent...
Autism is a disease of complex nature with significant genetic component. The importance renin-angiotensin system (RAS) elements in cognition and behavior besides the interaction angiotensin II (Ang II), main product angiotensin-converting enzyme (ACE), neurotransmitters CNS, especially dopamine, proposes involvement RAS autism. Since architecture autism has remained elusive, here we postulated that variations are associated autism.Considering relation between three polymorphisms ACE (I/D,...
Asthma is a chronic and complex inflammatory disease of the respiratory tract. Also, multiple sclerosis (MS) demyelinating central nervous system. Against this background, IL-33 IL1RL1 play critical role in autoimmune disorders. Here, we explored serum level two potential genetic variants IL33 gene its receptor Iranian asthma MS patients.This study consisted (n=140) patients (n=140), healthy subjects (n=72). Genotyping was carried out polymorphisms, rs1342326 variant rs10204137SNP genes,...
Maternal-fetal tolerance plays a fundamental role in the maintenance of pregnancy. However, this immunological can be influenced by intrauterine infections. Human amniotic epithelial cells (hAECs) have immunomodulatory effects and respond to invading pathogens through expressing various toll-like receptors (TLRs). We hypothesize that bacteria or bacterial products affect immunosuppressive hAECs TLR stimulation. Here, we investigated how successful pregnancy threatened TLR4 activation on...
Abstract Environmental and genetic factors play a fundamental role in the pathogenesis of basal cell carcinoma (BCC) defined as most common cancer skin. Programmed death‐1 (PD‐1), encoded by programmed ( PDCD1 ) gene, serves an inhibitory molecule suppression immune responses risk factor development different cancers. In this study, we investigated two single nucleotide polymorphisms (SNPs) within haplotypes these SNPs, BCC Iranian population. Whole blood samples were obtained from 210 320...
Autoimmunity is an identified factor for development of end-stage renal disease (ESRD). Regulatory T-cells (Tregs) play a fundamental role in preventing autoimmunity. This study aimed to determine Treg frequency and its effects on cytokine profile ESRD patients with without systemic lupus erythematosus (SLE). Moreover, this also determines how number affected by blood transfusion gender. Peripheral mononuclear cells were isolated from 26 10 healthy subjects stained anti-CD4, anti-CD25,...
The failure of immunological tolerance to self-antigens plays a fundamental role in the pathogenesis systemic lupus erythematosus (SLE). PD-1 is an inhibitory receptor for regulating immune system and preventing development autoimmune disorders. This study aimed determine four single-nucleotide polymorphisms (SNPs) within programmed cell death 1 (PDCD1 or PD-1) gene haplotypes defined by these SNPs susceptibility SLE Iranian population. Blood samples were obtained from 253 564 healthy...
The main focus of the current study is fabrication a multifunctional nanohybrid based on graphene oxide (GO)/iron oxide/gold nanoparticles (NPs) as combinatorial cancer treatment agent. Gold and iron NPs formed GONPs via in situ synthesis approach. characterisations showed that gold onto GO. Cell toxicity assessment revealed fabricated exhibited negligible against MCF-7 cells low doses (<50 ppm). Temperature measurement time dose-dependent heat elevation under interaction with radio...
Head and neck squamous cell carcinomas (HNSCCs) are the most common cancers of head sixth malignancy worldwide. Programmed death 1 (PD-1) is an immune inhibitory molecule which through interaction with its ligands recruits protein phosphatase resulting in response inhibition. Expression PD-1 on tumor cells considered as one crucial evasion mechanisms. This study aimed to investigate association gene polymorphisms at positions PD1.3 (rs11568821), PD1.5 (rs2227981) PD1.9 (rs2227982)...
Objective: Hepatocellular carcinoma (HCC) as a chronic liver condition is largely associated with immune responses. Previous studies have revealed that different subsets of lymphocytes play fundamental roles in controlling or improving the development and outcome solid tumors like HCC. Hence, this study aimed to investigate whether system changes were related disease HCC patients. Methods: Peripheral blood mononuclear cells isolated from 30 patients healthy volunteers using Ficoll density...
Background. Several animal studies have shown the roles of cytokines in regulating liver regeneration following resection (LR), which is a type surgery designed to remove cancerous tumors from liver. This study investigated how expressions and serum levels some pro- anti-inflammatory patients with hepatocellular carcinoma (HCC) were changed during LR. Methods. Liver tissues 15 HCC collected interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), IL-1α, IL-1 β, IL-10, transforming growth...
Systemic lupus erythematous (SLE) disease is a chronic autoimmune with unknown etiology that can involve different organs. Polymorphisms in Fcγ receptors have been identified as genetic factors susceptibility to SLE. This study was aimed investigate effects of two single nucleotide polymorphisms (SNPs) within FcγRIIB and FcγRIIIA genes on systemic activity index (SLEDAI) an Iranian population.Our findings indicated TT GG genotypes were the common SNPs SLE patients, respectively. There no...
Programmed death 1 (PD-1) has a central role in maintaining T cell tolerance and terminating cellular responses after eliminating antigens. Variation
Nuclear medicine patients are isolated in a room after the injection of radiopharmaceutical. They may be active Wi-Fi option its smartphone mobile or other environmental radiofrequency waves. The hypothesis this study was evaluation increased biological effects simultaneous exposure to gamma-ray and waves by measuring level double strand-breaks DNA peripheral blood lymphocyte rat.
Introduction: Crimean-Congo hemorrhagic fever (CCHF) is an acute viral and potentially fatal disease that endemic in the south east of Iran, especially Sistan Baluchestan. This study aimed to measure serum levels interferon-[1]r (IFN-[1]r) patients with CCHF, considering disseminated intravascular coagulation (DIC) severity. The second aim was determine correlation between IFN-[1]r DIC severity using guidance diagnosis treatment CCHF. Methods: Thirty-seven CCHF were studied. made, based on...