A5056923910- Bone Metabolism and Diseases
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Bone health and osteoporosis research
- Cell death mechanisms and regulation
- Viral Infectious Diseases and Gene Expression in Insects
- Autism Spectrum Disorder Research
- Pharmacological Effects of Medicinal Plants
- Botulinum Toxin and Related Neurological Disorders
- Diabetes Treatment and Management
- Single-cell and spatial transcriptomics
- Genomics and Chromatin Dynamics
- NF-κB Signaling Pathways
- Heat shock proteins research
- MicroRNA in disease regulation
- Immune Response and Inflammation
- GDF15 and Related Biomarkers
- Bone health and treatments
- Neuroblastoma Research and Treatments
- Immunotherapy and Immune Responses
- PARP inhibition in cancer therapy
- Signaling Pathways in Disease
- Ferroptosis and cancer prognosis
- Cytokine Signaling Pathways and Interactions
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Shandong University
2021-2024
Shandong Provincial Hospital
2021-2024
Shandong First Medical University
2022-2024
Affiliated Hospital of Qingdao University
2024
Shanxi Medical University
2022-2024
Shanxi Academy of Medical Sciences
2022-2024
Tongji Hospital
2022-2024
Huazhong University of Science and Technology
2022-2024
Qingdao University
2024
Abstract FKBP4 belongs to the family of immunophilins, which serve as a regulator for steroid receptor activity. Thus, has been recognized play critical role in several hormone-dependent cancers, including breast and prostate cancer. However, there is still no research address on lung adenocarcinoma (LUAD) progression. We found that expression was elevated LUAD samples predicted significantly shorter overall survival based TCGA our cohort patients. Furthermore, robustly increased...
Although the variation in chromatin architecture during adaptive immune responses has been thoroughly investigated, 3D landscape of innate immunity is still unknown. Herein, regulation and heterogeneity among human primary monocytes were investigated. Peripheral blood was collected from two healthy persons patients with systemic lupus erythematosus (SLE), CD14
Performing the differential diagnosis of Parkinson's disease (PD) and multiple-system atrophy parkinsonian type (MSA-P) is challenging. The oculomotor performances patients with PD MSA-P were investigated to explore their potential role as a biomarker for this differentiation.
Dementia is a common and serious non-motor symptom in Parkinson's disease (PD). We aimed to investigate the reflexive saccade PD patients explore its potential role as biomarker for cognitive decline.Using an infrared video-based eye tracker, we investigated saccades 94 115 healthy controls (HCs). Saccadic parameters were compared between HCs, also among subgroups. The correlation of saccadic performance with duration, severity cognition further investigated.Compared controls, had prolonged...
Protocatechualdehyde (PCA), an important component of Salvia miltiorrhiza, has many activities, such as anti-inflammatory and antisepsis activities. However, the role PCA in osteoclasts is not clear. We used RAW264.7 cells (a mouse leukemic monocyte/macrophage cell line) bone marrow macrophages (BMMs) to probe underlying mechanism. The effects on activity were evaluated with CCK-8 assays. TRAP staining detected mature osteoclasts. Corning Osteo Assay Surface plates examine absorption. levels...
In this study, we demonstrated that the expression of FK506 binding protein 51 (FKBP51) is upregulated in acute monocytic leukemia (AML-M5) cells by dexamethasone and aimed to investigate possible effects FKBP51 on growth cytarabine sensitivity AML-M5 cells. THP-1 U937cells were used establish cell models with overexpression knockdown, respectively. Cell proliferation, apoptosis response investigated cycle, CCK-8 Flow cytometry analyses. The mice experiment was conducted detect role...
Background and Purpose Recent evidence suggests that postmenopausal osteoporosis is associated with increased bone resorption function in osteoclasts, of which Cathepsin K a key molecule. In this study, we aimed to screen small molecule compounds targeting evaluate whether they affect osteoclast function. Experimental Approach We screened out the small-molecule compound NVP-BHG712 CTSK by molecular docking, studied its pharmacological effect on osteoclasts. To end, evaluated mass changes...