A5101556954- Trace Elements in Health
- Autophagy in Disease and Therapy
- Heavy Metal Exposure and Toxicity
- MicroRNA in disease regulation
- FOXO transcription factor regulation
- Iron Metabolism and Disorders
- Reproductive Biology and Fertility
- Traditional Chinese Medicine Studies
- Aluminum toxicity and tolerance in plants and animals
- Traditional Chinese Medicine Analysis
- Phytochemistry and biological activity of medicinal plants
- Biological and pharmacological studies of plants
- Ginkgo biloba and Cashew Applications
- Pharmacological Effects of Natural Compounds
- PI3K/AKT/mTOR signaling in cancer
- Reproductive System and Pregnancy
- Fullerene Chemistry and Applications
- Liver Disease and Transplantation
- Medicinal Plants and Bioactive Compounds
- Protein Tyrosine Phosphatases
- Ubiquitin and proteasome pathways
- Morinda citrifolia extract uses
- Case Reports on Hematomas
- Heme Oxygenase-1 and Carbon Monoxide
- Thyroid Disorders and Treatments
Huashan Hospital
2025
Fudan University
2025
Jiangsu Industry Technology Research Institute
2025
Anhui University of Traditional Chinese Medicine
2018-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2007-2024
Shandong University
2024
Shandong Provincial Hospital
2024
Shandong First Medical University
2024
Fujian Provincial Cancer Hospital
2024
Fujian Medical University
2024
The urate transporter 1 (URAT1) is the primary in kidney responsible for reabsorption and, therefore, crucial homeostasis. Hyperuricemia causes common human disease gout and other pathological consequences. Inhibition of through URAT1 has been shown as a promising strategy alleviating hyperuricemia, clinical preclinical drug candidates targeting are emerging. However, how small molecules inhibit remains undefined, lack accurate complex structures hinders development better therapeutics....
Abstract Background Wilson’s disease (WD) is an autosomal recessive disorder of copper metabolism caused by ATP7B (encoding a copper-transporting P-type ATPase) variants that shows various characteristics according to race and geographical region. This study was aimed provide comprehensive analysis in China investigate plausible role common WD manifestations. Methods A total 1366 patients (1302 index 64 siblings) clinically diagnosed with (Leipzig score ≥ 4) were recruited. They underwent...
Ginkgo ketoester tablets (GT) and donepezil were a clinically used combination for the treatment of Alzheimer’s disease (AD). The aim study was undertaken to investigate antiamnesic effects two drugs alone in through vivo models Morris water maze along with vitro antioxidants, acetylcholinesterase (AChE) butyrylcholinesterase (BuChE). potential mechanisms speculated by activities acetylcholine (ACh), AChE, superoxide dismutase (SOD), malondialdehyde (MDA) protein expression brain-derived...
Objective . Gandouling (GDL) tablet is a Chinese patent medicine approved by the National Medical Product Administration, which used to treat Wilson disease (WD) in China. In this study, we aimed investigate effects of GDL on mitophagy hippocampus toxic milk (TX) mouse model WD. Methods Mice were randomly divided into following four groups: control, (model group), D‐penicillamine (DPA), and groups. The animal behaviors evaluated water maze experiment, traction test, pole test. Transmission...
The aim of this study was to construct curcumin‐loaded mesenchymal stem cell‐derived exosomes (Cur‐exos) and explore their effects on nonalcoholic fatty liver disease (NAFLD) models both in vitro vivo. Cur‐exos were prepared using three common drug‐loading techniques—incubation, sonication, freeze–thaw cycles. Among these, via repeated freeze–thawing demonstrated higher encapsulation efficiency rates than those produced by other methods. In vitro, exhibited enhanced stability, efficiently...
Objective To study the effect of salt reduction on iodine status and to determine whether consumption was still adequate after in a population where universal iodisation is mandatory. Design A substudy cluster randomised controlled trial, with schools randomly assigned either intervention or control group. Setting 28 primary Changzhi, northern China. Participants 279 children grade 5 school (mean age: 10.1); 553 adults (age: 43.8). Intervention Children were educated about harmful effects...
Gandoufumu decoction (GDFMD) is a traditional Chinese medicine that has been widely used to treat Wilson's disease (WD) liver damage patients. However, its specific molecular mechanism currently remains unclear. Autophagy as key contributor WD intensely researched in the recent years. Therefore, aim of this present study explore effect GDFMD on autophagy damage, and final purpose provide scientific evidence for treatment damage.The mechanisms autophagy-related pathways were predicted using...
Splenomegaly and pancytopenia are common in Wilson's disease (WD) splenectomy is one of the conventional treatments for splenomegaly associated pancytopenia. However, remained controversial hypersplenism WD as it was reported that leaded to serious emotional neurological deterioration patients with hypersplenism. In current study, we present our experiences 70 who had undergone splenectomy, outlining safety efficacy WD. The clinical database hospital between 2009 2013 were reviewed...
Abstract Background Even though recent research has achieved significant advancement in the development of therapeutic approaches for Wilson’s diseases (WD), current treatment options available WD are still limited, especially patients with neurological symptoms. This study is intended to compare symptoms receiving either combined sodium 2, 3-dimercapto-1-propane sulfonate (DMPS) and zinc or D-penicillamine (DPA) monotherapy as first-line therapy, identify more effective approach. Methods...
Ischemic stroke is a common neurological disease that can lead to mortality and disability. The current curative effect remains unsatisfactory because drug accumulation in the diseased areas insufficient as result of unique blood–brain barrier. Therefore, much attention has been paid develop novel therapeutic compound, paeonol-ozagrel conjugate (POC), for ischemic stroke. Then, POC was successfully synthesized by conjugating paeonol ozagrel mutual prodrug. A series vitro characterizations...
To investigate the effect and safety of Gandouling plus low-dose D-penicillamine for treating patients with Wilson's disease (WD) who have neurological symptoms. WD symptoms were divided into two groups: a treatment group (n = 53) control 50). The received anti-copper therapy combination (10 mg/kg), whereas was conventional dose (20 mg/kg) monotherapy. clinical efficacies, adverse reactions, results various hematological biochemical investigations recorded analyzed statistically. Overall,...
To evaluate the efficacy and safety of gandouling plus sodium dimercaptosulphonate (DMPS) on neurological Wilson's disease (WD) in patients.We retrospectively evaluated clinical records 125 WD patients with syndromes who were treated DMPS or used alone. All had a history deterioration during their diseases courses. The efficacies, adverse reactions, results various hematological biochemical investigations recorded for statistical analysis.92.30% (60 patients) combined therapy experienced an...
On the basis of high resolution crystal structures bovine rhodopsin, human beta2-adrenergic receptor and A2a adenosine receptor, three-dimensional structure histamine H2 (HHR2) was developed by homology modeling. Results evaluations suggest that a quality model for HHR2 has been obtained. Three antagonists, cimetidine, ranitidine nizatidine, were applied to binding site study with this through molecular docking, dynamics simulations mechanics-Poisson-Boltzmann surface area calculations. One...
Liver fibrosis is a fundamental pathological alteration observed in individuals with Wilson disease. Quercetin (Que) has shown potential inhibiting various diseases. However, the precise mechanism by which Que alleviates liver disease remains unclear. The present study aimed to investigate role of using male Toxic Milk (TX) mice and Cu2+-induced hepatoblastoma cells (HepG2 cells). In TX mice, Analyses Histopathology , Immunohistochemical staining, Enzyme-linked immunosorbent assay (ELISA),...
Abstract Wilson disease (WD) is a severely autosomal genetic disorder triggered by dysregulated copper metabolism. Autophagy and apoptosis share common modulators that process cellular death. Emerging evidences suggest Forkhead Box O1 over‐expression (FoxO1‐OE) aggravates abnormal autophagy to induce neuronal injury. However, the underlying mechanisms remain undetermined. Herein, aim of this study was investigate how regulating FoxO1 affects attenuate injury in well‐established WD cell...
Patients with lung adenocarcinoma (LUAD) generally have poor prognosis. The role of striatin-interacting protein 2 (STRIP2) in LUAD remain unclear.