A5018942561- Drug-Induced Adverse Reactions
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Allergic Rhinitis and Sensitization
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammatory mediators and NSAID effects
- Sinusitis and nasal conditions
- Olfactory and Sensory Function Studies
- COVID-19 Clinical Research Studies
- Advanced Chemical Sensor Technologies
- Pregnancy and Medication Impact
- Platelet Disorders and Treatments
- Pharmaceutical studies and practices
- Head and Neck Surgical Oncology
- Reproductive System and Pregnancy
- SARS-CoV-2 detection and testing
- Case Reports on Hematomas
- SARS-CoV-2 and COVID-19 Research
- Pregnancy and preeclampsia studies
- Anesthesia and Pain Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cystic Fibrosis Research Advances
Brigham and Women's Hospital
2014-2024
Harvard University
2014-2021
The impact of anosmia on quality-of-life (QoL) for patients with aspirin-exacerbated respiratory disease (AERD) is poorly understood. We aimed to investigate how the severity smell loss and olfactory dysfunction (OD) in AERD affects their QoL, mental health physical well-being.Five validated QoL questionnaires (Sinonasal Outcome Test-22, Asthma Control Test, Healthy Days Core Module-4, Short Form-36 Patient Health Questionnaire-4) two newly developed assessing consequences OD were...
Patients with aspirin-exacerbated respiratory disease (AERD) have difficult-to-treat asthma and chronic rhinosinusitis nasal polyps (CRSwNP) often require treatment biologic therapy for or CRSwNP. Healthcare utilization in patients AERD has not been well described since the advent of biologics.
Aspirin-exacerbated respiratory disease (AERD) is a difficult-to-treat syndrome where timely diagnosis and initiation of disease-specific therapies are pertinent to improved patient outcomes.To characterize the most common timeline for development clinical triad [asthma, nasal polyposis, reactions nonsteroidal anti-inflammatory drugs (NSAIDs)], identify barriers prompt AERD, describe indications an aspirin challenge facilitate accurate diagnosis.Six hundred ninety-seven patients with...
Background: Olfactory dysfunction (OD) and smell loss affects aspects of patients' everyday life lowers their quality life. OD questionnaires are considered one the core-outcome measures in chronic rhinosinusitis, but many existing contained pandemic-prohibitive questions on social gatherings or restaurant visits, were too culture specific gender specific, overly long cumbersome. Objective: We aimed to develop a new brief questionnaire assess impact consequences its burden daily This study...
Clinical Implications•We report a series of patients with aspirin-exacerbated respiratory disease who became infected severe acute syndrome coronavirus 2. Most these had been treated biologics for their baseline and did not appear to experience increased morbidity related 2019. •We Early in the (SARS-CoV-2) pandemic, asthma was understood be risk factor poor outcomes those infected. Yet, as understanding matured, consistently observed factor. Because is heterogeneous disorder, endotypes may...