A5089208923- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
- HIV/AIDS drug development and treatment
- Machine Learning in Bioinformatics
- Biochemical and Molecular Research
- Microtubule and mitosis dynamics
- Carbohydrate Chemistry and Synthesis
- Ubiquitin and proteasome pathways
- Drug Transport and Resistance Mechanisms
- Protein Degradation and Inhibitors
- RNA Research and Splicing
University of Michigan
2021-2025
Beloit College
2017
Polycomb Repressive Complex 1 (PRC1) is associated with transcriptional silencing, and its dysregulation plays an important role in various cancers. Well-characterized PRC1 inhibitors can facilitate the exploration of inhibition as therapeutic agents. By employing NMR-based fragment screening approach, we have previously identified a very weak millimolar ligand RB-1, which directly binds to RING1B-BMI1. Then, reported low-micromolar inhibitor, RB-3, active leukemic cells, showing H2A...
Abstract Background: Polycomb repressive complex 1 (PRC1) is an epigenetic regulatory that monoubiquitinates H2A on lysine 119 and involved in gene regulation development, resulting the repression of target genes important for cellular identity, stemness differentiation. Activity PRC1 maintained by E3 ligases RING1A or RING1B. Recent studies implicate RING1B various cancers highlights importance function maintenance proliferation leukemic stem cells. This demonstrated has role acute...
Abstract Background: Polycomb repressive complex 1 (PRC1) is an epigenetic regulatory that monoubiquitinates lysine 119 on histone H2A, resulting in the repression of target genes. The canonical core PRC1 responsible for its E3 ligase activity a heterodimeric unit comprised RING1B and BMI1. Emerging data implicates various cancers highlights importance function maintenance proliferation leukemic stem cells. Studies demonstrate loss through knockdown impairs cell proliferation, causes...
One of the greatest threats to human health is rise antibiotic resistance in pathogenic bacteria, and failure treatment becoming far more common. Aminoglycosides, a family antibiotics, are too often being rendered ineffective by bacterial aminoglycoside modifying enzymes. Of various types enzymes, most common clinical isolates AAC(6′)‐Ib enzyme. In order combat modification enzyme, previous work has screened potential small molecule inhibitors identified lead inhibitor. We working synthesize...