A5073163034- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Genomics and Phylogenetic Studies
- interferon and immune responses
- Plant-Microbe Interactions and Immunity
- Palliative Care and End-of-Life Issues
- CAR-T cell therapy research
- Childhood Cancer Survivors' Quality of Life
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Immunodeficiency and Autoimmune Disorders
- Diabetes and associated disorders
- Plant Pathogens and Fungal Diseases
- Gut microbiota and health
- Chromosomal and Genetic Variations
- Immune responses and vaccinations
- Immune Response and Inflammation
- Transgenic Plants and Applications
- Blockchain Technology Applications and Security
- RNA regulation and disease
- HIV Research and Treatment
- Plant tissue culture and regeneration
- Family Support in Illness
- Rabies epidemiology and control
Center for Excellence in Molecular Cell Science
2020-2025
University of Chinese Academy of Sciences
2022-2025
Stanford University
2024-2025
Second Xiangya Hospital of Central South University
2024
Central South University
2024
Henan Academy of Agricultural Sciences
2022
Institute of Plant Protection
2022
Zhengzhou University
2022
Hainan University
2022
Chinese Academy of Sciences
2020
Cucumber wilt caused by Fusarium oxysporum f.sp. cucumerinum ( Foc ) is a highly destructive disease that leads to reduced yield in cucumbers. In this study, strain YB-04 was isolated from wheat straw and identified as Bacillus subtilis. It displayed strong antagonistic activity against F. dual culture exhibited significant biocontrol of cucumber with higher control effect than those previously reported strains pronounced growth promotion seedlings. B. subtilis could secrete extracellular...
Fusarium crown rot caused by pseudograminearum is one of the most devastating diseases wheat worldwide causing major yield and economic losses. In this study, strain YB-15 was isolated from soil rhizosphere classified as Bacillus subtilis average nucleotide identity analysis. It significantly reduced with a control efficacy 81.50% improved growth seedlings increasing root shoot fresh weight 11.4% 4.2%, respectively. Reduced may have been due to direct antagonism production β-1, 3-glucanase,...
Authorization of the Matrix-M (MM)–adjuvanted R21 vaccine by three countries and its subsequent endorsement World Health Organization for malaria prevention in children are a milestone fight against malaria. Yet, our understanding innate adaptive immune responses elicited this remains limited. Here, we compared clinically relevant adjuvants [3M-052 + aluminum hydroxide (Alum) (3M), TLR7/8 agonist formulated Alum; GLA-LSQ, TLR4 liposomes with QS-21; MM, now-approved adjuvant R21] their...
Insertions and deletions (indels) are low-frequency deleterious genomic DNA alterations. Despite their rarity, indels common, insertions leading to long complementarity-determining region 3 (CDR3) vital for antigen-binding functions in broadly neutralizing polyreactive antibodies targeting viruses. Because of challenges detecting indels, the mechanism that generates during immunoglobulin diversification processes remains poorly understood. We carried out ultra-deep profiling systematically...
Article26 April 2022Open Access Source DataTransparent process C-terminal deletion-induced condensation sequesters AID from IgH targets in immunodeficiency Xia Xie orcid.org/0000-0002-0423-976X State Key Laboratory of Molecular Biology, CAS Center for Excellence Cell Science, Shanghai Institute Biochemistry and Chinese Academy Sciences, University Shanghai, China Contribution: Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Methodology, Writing - review &...
Abstract Activation-induced cytidine deaminase (AID) initiates both antibody class switch recombination (CSR) and somatic hypermutation (SHM) in diversification. DNA double-strand break response (DSBR) factors promote rearrangement CSR, while translesion synthesis (TLS) polymerases generate mutations SHM. REV7, a component of TLS polymerase zeta, is also downstream effector 53BP1-RIF1 DSBR pathway. Here, we study the multi-functions REV7 find that required for B cell survival upon...
Adolescents and young adults (AYAs) cancer patients face higher long-term late-stage risks, so advance care planning (ACP) is an important way for them to participate autonomously in healthcare decision-making. However, Chinese culture, discussing ACP with AYAs challengeable due their role as family's hope, contributing insufficient attention this group care. This study aimed explore the perceptions of AYA patients, families, providers about based on health belief model. was a qualitative...