A5087731444- Cancer, Hypoxia, and Metabolism
- Adrenal and Paraganglionic Tumors
- Epigenetics and DNA Methylation
- Heparin-Induced Thrombocytopenia and Thrombosis
- Neuroblastoma Research and Treatments
- Hormonal Regulation and Hypertension
- Venous Thromboembolism Diagnosis and Management
- Renal and related cancers
- Atrial Fibrillation Management and Outcomes
- Cancer, Lipids, and Metabolism
- Mechanical Circulatory Support Devices
- Cancer-related gene regulation
- Signaling Pathways in Disease
- Reproductive System and Pregnancy
- T-cell and B-cell Immunology
- Case Reports on Hematomas
- Zebrafish Biomedical Research Applications
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Pituitary Gland Disorders and Treatments
- Endometriosis Research and Treatment
- Pregnancy and Medication Impact
- Microtubule and mitosis dynamics
- Thyroid Cancer Diagnosis and Treatment
Institute of Molecular Medicine
2023
The University of Texas Medical Branch at Galveston
2022
Karolinska University Hospital
2005-2021
KTH Royal Institute of Technology
2009
Karolinska Institutet
2002-2008
University of Pecs
2003
Abstract IgD has been suggested to be a recently developed Ig class, only present in rodents and primates. However, this paper the cow, sheep, pig δ genes have identified shown transcriptionally active. The deduced amino acid sequences from their cDNAs show that artiodactyl H chains are structurally similar human IgD, where chain constant regions all contain three domains hinge region, sharing homologies of 43.6, 44, 46.8% with counterpart, respectively. According phylogenetic analysis, Cδ...
Tumours in the adrenocortex are common human tumours. Malignancy is however, rare, yearly incidence being 0.5-2 per million inhabitants, but associated with a very aggressive behaviour. Adrenocortical tumours often altered hormone production variety of clinical symptoms. The aggressiveness carcinomas together high frequency adenomas calls for deeper understanding underlying biological mechanisms and an improvement diagnostic possibilities.Microarray gene expression analysis was performed...
Abstract Purpose: This study aims to quantitatively assess promoter and global methylation changes in pheochromocytomas abdominal paragangliomas its relation tumor phenotypes. Experimental Design: A panel of 53 primary tumors (42 benign, 11 malignant) was analyzed by quantitative bisulfite pyrosequencing. Based on levels the suppressor genes, p16INK4A, CDH1, DCR2, RARB, RASSF1A, NORE1A, TP73, APC, DAPK1, p14ARF, PTEN, a CpG island methylator phenotype (CIMP) defined as concerted...
Par G, Geli J, Kozma N, Varga P, Szekeres‐Bartho J. Progesterone regulates IL12 expression in pregnancy lymphocytes by inhibiting phospholipase A2. AJRI 2003; 49:1–5 © Blackwell Munksgaard, 2003 PROBLEM: Progesterone‐induced blocking factor (PIBF) is one of the pathways that mediate immunological effects progesterone. PIBF inhibits natural killer (NK) cytotoxic activity. Recently we showed neutralization results an increased interleukin (IL)‐12 expression, which corrected cyclooxygenase...
Context: The Ras effector NORE1A (RASSF5A) is a putative tumor suppressor and inactivated in several human cancers. has not been studied thyroid cancer.
NORE1A (RASSF5) and RASSF1A are newly described Ras effectors with tumour suppressor functions. Both molecules frequently inactivated in various cancers. In this study, we aimed to explore the potential involvement of pheochromocytoma abdominal paraganglioma tumorigenesis. A panel 54 primary tumours was analysed for mRNA expression by TaqMan quantitative RT-PCR. Furthermore, promoter methylation assessed combined bisulphite restriction endonuclease assay methylation-sensitive Pyrosequencing...
Extracorporeal membrane oxygenation (ECMO) is a widely used technique to provide circulatory and/or respiratory support in critically ill patients. ECMO treatment usually necessitates systemic anticoagulation. Unfractionated Heparin (UFH) commonly anticoagulant patients on support. In situations where UFH contraindicated, alternative anticoagulation strategies can be applied, such as the use of direct thrombin inhibitors (DTI). Bivalirudin and argatroban are most DTIs. this report we give...
Abstract Background In this study we aimed to quantify tumor suppressor gene (TSG) promoter methylation densities levels in primary neuroblastoma tumors and cell lines. A subset of these TSGs is associated with a CpG island methylator phenotype (CIMP) other types. Methods The panel consisted 38 tumors, 7 established lines 4 healthy references. Promoter was determined by bisulphate Pyrosequencing for 14 TSGs; LINE-1 repeat element used as an indicator global levels. Results Overall mean TSG...
Recurrent alterations in promoter methylation of tumor suppressor genes (TSGs) and LINE1 ( L1RE1 ) repeat elements were previously reported pheochromocytoma abdominal paraganglioma. This study was undertaken to explore CpG abnormalities an extended panel assess possible relationships between metastatic disease mutation status. quantified by bisulfite pyrosequencing for selected TSG promoters repeats. Methylation indices above normal reference observed DCR2 TNFRSF10D ), CDH1 , P16 CDKN2A RARB...
Abstract Pheochromocytoma is a predominantly sporadic neuroendocrine tumor derived from the adrenal medulla. Previous low resolution LOH and metaphase‐CGH studies reported loss of chromosomes 1p, 3q, 17p 22q at various frequencies. However, molecular mechanism(s) behind development pheochromocytoma remains largely unknown. We have applied high‐resolution tiling‐path microarray‐CGH with primary aim to characterize copy number imbalances affecting chromosome 22 in 66 pheochromocytomas....
Pheochromocytomas and abdominal extra-adrenal paragangliomas are related to endocrine tumors of the sympathetic nervous system. Studies in animal models have shown that inactivation products cyclin dependent kinase inhibitor 2A (CDKN2A) gene locus, p16INK4A p14ARF, promotes development pheochromocytoma, especially malignant form. The present study evaluated involvement CDKN2A human pheochromocytomas from 55 patients. Promoter methylation was assessed using quantitative Pyrosequencing...
Pheochromocytomas and abdominal paragangliomas are rare catecholamine-producing tumours arising from neural crest-derived chromaffin cells. Frequent deletions of several distinct regions on the short arm chromosome 1 suggest their involvement in tumourigenesis process. The RIZ1 tumour suppressor encoded by RIZ gene 1p36.21 represents an attractive candidate target for distal 1p these tumours. A panel 18 pheochromocytomas (14 benign, 4 malignant) 11 (4 7 were characterised somatic mRNA...
Abstract The putative tumor suppressor NORE1A (RASSF5) is a member of the Ras association domain family and commonly inactivated in human cancer. closely related gene functional collaborator RASSF1A bona fide frequently involved neuroblastoma. In present study, we sought to investigate role A panel tumors (36 neuroblastomas 4 ganglioneuromas) neuroblastoma cell lines was assessed for expression by Taqman quantitative RT‐PCR. Promoter methylation quantitatively determined sensitive...
<div>Abstract<p><b>Purpose:</b> This study aims to quantitatively assess promoter and global methylation changes in pheochromocytomas abdominal paragangliomas its relation tumor phenotypes.</p><p><b>Experimental Design:</b> A panel of 53 primary tumors (42 benign, 11 malignant) was analyzed by quantitative bisulfite pyrosequencing. Based on levels the suppressor genes, <i>p16<sup>INK4A</sup>, CDH1, DCR2, RARB, RASSF1A, NORE1A,...
<div>Abstract<p><b>Purpose:</b> This study aims to quantitatively assess promoter and global methylation changes in pheochromocytomas abdominal paragangliomas its relation tumor phenotypes.</p><p><b>Experimental Design:</b> A panel of 53 primary tumors (42 benign, 11 malignant) was analyzed by quantitative bisulfite pyrosequencing. Based on levels the suppressor genes, <i>p16<sup>INK4A</sup>, CDH1, DCR2, RARB, RASSF1A, NORE1A,...